Results 221 to 230 of about 4,663,034 (296)

Identifying viral infections through metagenomic Next Generation Sequencing of undiagnosed respiratory fevers in Madagascar (2014-2019). [PDF]

BMC Infect Dis
Lockwood S, Ranaivoson HC, Randriambolamanantsoa TH, Razanajatovo N, Raharinosy V, Ahyong V, Héraud JM, Dussart P, Lacoste V, Brook CE.   +9 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Application of metagenomic next-generation sequencing as an adjunct to conventional microbiological testing for the diagnosis of infection in kidney transplant recipients. [PDF]

Front Cell Infect Microbiol
Vuth H, Wang W, Qin W, Yang M, Li Y, Zhou Q, Xu X, Zhang J, Zhao H.   +8 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Potential of plasma metagenomic next-generation sequencing to guide antibiotic therapy in acute necrotizing pancreatitis with early fever: a prospective multicenter cohort study. [PDF]

Antimicrob Resist Infect Control
Hong X, Shen D, Lin C, Cao X, Sun Z, Liu B, Guo R, Liu Z, Luo T, Yu Y, Yang M, Feng B, Zhang W, Huang G.   +13 more
europepmc   +1 more source

Washed Microbiota Transplantation Improves Chronic‐Phase Febrile Infection‐Related Epilepsy Syndrome: The First Case Report With Long‐Term Follow‐Up and Integrated Multi‐Omics Analysis

Microbiota Medicine Research, EarlyView.
ABSTRACT Background Febrile infection‐related epilepsy syndrome (FIRES) is a catastrophic epileptic encephalopathy. Survivors often enter a chronic phase characterized by drug‐resistant epilepsy, cognitive impairment, behavioral and psychiatric symptoms, and long‐term functional disability.
Qianqian Li, Xiao Ding, Sheng Zhang, Faming Zhang   +3 more
wiley   +1 more source

Rapid diagnosis of Lemierre's syndrome by metagenomic next-generation sequencing: a case report. [PDF]

Front Med (Lausanne)
Wang Y, Zhang X.
europepmc   +1 more source

Uptake, metabolism, and bioremediation of neonicotinoid insecticides in soil–plant systems: A review

New Plant Protection, EarlyView.
This review summarizes the uptake and metabolic transformation of neonicotinoid insecticides in plants, showing that some metabolites exhibit higher toxicity. We also critically assess promising bioremediation strategies using microbes and plant–microbe interactions to reduce residue contamination.
Wenwen Guo, Jiayue Liu, Yichen Yang, Hui Li, Runan Li, Yuanbo Li   +5 more
wiley   +1 more source

The complexity of invasive fungal diseases in the intensive care unit: evaluation of metagenomic next-generation sequencing. [PDF]

Front Cell Infect Microbiol
Wang R, Yang H, Zhang C, Zi Neng X.
europepmc   +1 more source

The diagnostic and prognostic utility of blood metagenomic next-generation sequencing for invasive pulmonary aspergillosis. [PDF]

Microbiol Spectr
Chen Y, Tang X, Lu S, Guo L, Wang L, Min L, Niu T, Zhou Y.   +7 more
europepmc   +1 more source