Results 51 to 60 of about 6,252 (250)

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

Metagenomic next-generation sequencing for the etiological diagnosis of rabies virus in cerebrospinal fluid

, 2023
Background: Rabies is a highly fatal disease. Once symptoms develop, death usually occurs within days. Survivors were occasionally reported in the literatures. Ante-mortem diagnosis remains a challenge in most rabies endemic countries.
Tian, Jinfei, Peng, Jie, Li, Xing, Gao, Junling, Mo, Xichao, Feng, Ye, Wang, Yuyang, Willoughby, Rodney E., Liu, Yong, Weng, Xing   +9 more
core   +1 more source

A Rare Bird: Diagnosis of Psittacosis Meningitis by Clinical Metagenomic Next-Generation Sequencing [PDF]

, 2021
Psittacosis is a zoonotic infectious disease caused by the transmission of Chlamydia psittaci; it often presents as a pulmonary infection but rarely as disseminated disease.
Chiu, CY, Miller, S, Davar, K, Wilson, MR, Vijayan, T   +4 more
core   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

EBI metagenomics—a new resource for the analysis and archiving of metagenomic data [PDF]

, 2013
Metagenomics is a relatively recently established but rapidly expanding field that uses high-throughput next-generation sequencing technologies to characterize the microbial communities inhabiting different ecosystems (including oceans, lakes, soil ...
Vaughan, Daniel, Mitchell, Alex, Field, Dawn, Gonzalez-Beltran, Alejandra, Scheremetjew, Maxim, McAnulla, Craig, Sansone, Susanna-Assunta, Sterk, Peter, Radhakrishnan, Rajesh, Hunter, Sarah, Leinonen, Rasko, Jones, Philip, Jones Philip, Denise, Hubert, Cochrane, Guy, Maslen, John, Oisel, Arnaud, Pesseat, Sebastien, Hubert, Denise, Corbett, Matthew, Fraser, Matthew, Rocca-Serra, Philippe, Hunter, Christopher, Michell, Alex, Maguire, Eamonn, Gift, Nuka, Nuka, Gift   +26 more
core   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Clinical Analysis of Metagenomic Next-Generation Sequencing Confirmed Chlamydia psittaci Pneumonia: A Case Series and Literature Review

Infection and Drug Resistance, 2021
Xin-Qi Teng,1,* Wen-Cheng Gong,2,* Ting-Ting Qi,1 Guo-Hua Li,1 Qiang Qu,3 Qiong Lu,1 Jian Qu1 1Department of Pharmacy, The Second Xiangya Hospital, Central South University; Institute of Clinical Pharmacy, Central South University, Changsha, People’
Teng XQ, Gong WC, Qi TT, Li GH, Qu Q, Lu Q, Qu J   +6 more
doaj  

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Recommendations for the introduction of metagenomic next-generation sequencing in clinical virology, part II: bioinformatic analysis and reporting.

, 2021
Metagenomic next-generation sequencing (mNGS) is an untargeted technique for determination of microbial DNA/RNA sequences in a variety of sample types from patients with infectious syndromes.
Couto N, Sayiner A, de Vries JJC, Kubacki J, Le Mercier P, Zaheri M, Tsioka K, Cataluna AP, ESCV Network on Next-Generation Sequencing, Huber M, Carbo EC, Bachofen C, Simmonds P, Oude Munnink BB, Beer M, Fischer N, Rodriquez C, Hernandez M, Papa A, Hönemann M, Brown JR, Höper D, Lebrand A, Schmitz D, Claas ECJ, López Labrador, F. Xavier, Matamoros S, Sidorov I, Puchhammer-Stöckl E   +28 more
core   +2 more sources

Diagnostic metagenomics : potential applications to bacterial, viral and parasitic infections [PDF]

, 2014
The term 'shotgun metagenomics' is applied to the direct sequencing of DNA extracted from a sample without culture or target-specific amplification or capture.
M. J. Pallen, Pallen, Mark J.
core   +1 more source