Results 51 to 60 of about 58,932 (285)

Metatranscriptome of human faecal microbial communities in a cohort of adult men [PDF]

, 2018
The gut microbiome is intimately related to human health, but it is not yet known which functional activities are driven by specific microorganisms\u27 ecological configurations or transcription.
Abu-Ali, Galeb S., Branck, Tobyn, Chan, Andrew T., Drew, David A., DuLong, Casey, Huttenhower, Curtis, Ivey, Kerry L., Izard, Jacques, Lloyd-Price, Jason, Mallick, Himel, Mehta, Raaj S., Rimm, Eric   +11 more
core   +2 more sources

Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023

Emerging Infectious Diseases
We used clinical metagenomic next-generation sequencing of cerebrospinal fluid to investigate bunyavirus infections in 2 immunocompromised patients in the United States who had fatal meningoencephalitis.
Charles Y. Chiu, Raja Rama Godasi, Holly R. Hughes, Venice Servellita, Kafaya Foresythe, Asritha Tubati, Kelsey Zorn, Sukhman Sidhu, Michael R. Wilson, Sai Varun Bethina, Daniel Abenroth, Yee Cheng, Raymond Grams, Camilla Reese, Carlos Isada, Neeharika Thottempudi   +15 more
doaj   +1 more source

Species-level functional profiling of metagenomes and metatranscriptomes. [PDF]

, 2018
Functional profiles of microbial communities are typically generated using comprehensive metagenomic or metatranscriptomic sequence read searches, which are time-consuming, prone to spurious mapping, and often limited to community-level quantification ...
A Sczyrba, A Shafquat, AE Duran-Pinedo, AK Sharma, B Buchfink, B Langmead, BE Suzek, BK Swan, C Burke, C Luo, Curtis Huttenhower, D Medini, DH Huson, DT Truong, DT Truong, E Pasolli, EA Franzosa, EA Franzosa, Eric A. Franzosa, George Weingart, GG Silva, Gholamali Rahnavard, H Hauswedell, J Kim, J Lloyd-Price, J Lloyd-Price, J Ravel, J. Gregory Caporaso, JA Fuhrman, K Huang, Karen Schwarzberg Lipson, Lauren J. McIver, LR Thompson, LR Thompson, Luke R. Thompson, M Hamady, M Kanehisa, M Scholz, Melanie Schirmer, MY Galperin, N Segata, N Segata, Nicola Segata, OU Mason, P Petrenko, PJ Turnbaugh, R Caspi, RC Edgar, RD Finn, Rob Knight, S Abubucker, S Nayfach, S Sunagawa, S Sunagawa, T Bose, UniProt Consortium., W Huang, Y Ye, Y Zhao   +58 more
core   +2 more sources

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Steps in Metagenomics: Let’s Avoid Garbage in and Garbage Out [PDF]

, 2015
Is metagenomics a revolution or a new fad? Metagenomics is tightly associated with the availability of next-generation sequencing in all its implementations.
Izard, Jacques
core   +1 more source

Extreme Scale De Novo Metagenome Assembly [PDF]

, 2018
Metagenome assembly is the process of transforming a set of short, overlapping, and potentially erroneous DNA segments from environmental samples into the accurate representation of the underlying microbiomes's genomes. State-of-the-art tools require big
Arndt, Bill, Buluc, Aydin, Egan, Rob, Georganas, Evangelos, Goltsman, Eugene, Hofmeyr, Steven, Oliker, Leonid, Tritt, Andrew, Yelick, Katherine   +8 more
core   +3 more sources

Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis

Advanced Science, EarlyView.
The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu, Yuan Wang, Hengxuan Cai, Qianwen Yue, Xueli Liu, Xuanwen Bao, Zeng Wang, Xuehan Li, Lai Wei, Zhihua Zhang, Fan Xing, Yi Xu, Xianjun Li, Wei Xu   +13 more
wiley   +1 more source

Genome Sequence of a Divergent Avian Metapneumovirus from a Monk Parakeet (Myiopsitta monachus). [PDF]

, 2019
Here, we report the coding-complete genome sequence of an avian metapneumovirus from a monk parakeet (Myiopsitta monachus), identified by metagenomic next-generation sequencing during an investigation into a disease outbreak in a captive parrot breeding ...
Clubb, Susan, DeRisi, Joseph L, Retallack, Hanna   +2 more
core  

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source