Results 1 to 10 of about 58,396 (229)

Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors [PDF]

Communications Chemistry
Antibiotic resistance is a growing global health threat that risks the lives of millions. Among the resistance mechanisms, that mediated by metallo-β-lactamases is of particular concern as these bacterial enzymes dismantle most β-lactam antibiotics ...
Kinga Virág Gulyás, Liping Zhou, Daniel Salamonsen, Andreas Prester, Kim Bartels, Robert Bosman, Paul Haffke, Jintian Li, Viola Tamási, Fritz Deufel, Johannes Thoma, Anna Andersson Rasmussen, Miklós Csala, Hanna-Kirsti Schroder Leiros, Zhijian Xu, Mikael Widersten, Holger Rohde, Eike C. Schulz, Weiliang Zhu, Máté Erdélyi   +19 more
doaj   +7 more sources

Discovery of potential inhibitors against New Delhi metallo-β-lactamase-1 from natural compounds: in silico-based methods

Scientific Reports, 2021
New Delhi metallo-β-lactamase variants and different types of metallo-β-lactamases have attracted enormous consideration for hydrolyzing almost all β-lactam antibiotics, which leads to multi drug resistance bacteria.
Azhar Salari-jazi, Karim Mahnam, Parisa Sadeghi, Mohamad Sadegh Damavandi, Jamshid Faghri   +4 more
doaj   +2 more sources

Rapid Typing of Extended-Spectrum β-Lactamase (ESBL)- and Metallo-β-Lactamase (MBL)-Producing Enterobacterales Using Fourier Transform Infrared (FT-IR) Spectroscopy. [PDF]

Microbiologyopen
Clinical isolates of Klebsiella pneumoniae and Enterobacter cloacae complex were analyzed using FT‐IR spectroscopy and genotyping methods. High concordance was observed, demonstrating the potential of FT‐IR spectroscopy as a rapid screening tool.
Kawamoto Y, Kosai K, Murata M, Ota K, Mitsumoto-Kaseida F, Kaku N, Hasegawa H, Izumikawa K, Mukae H, Yanagihara K.   +9 more
europepmc   +2 more sources

In vitro activity and resistance mechanisms of novel antimicrobial agents against metallo-β-lactamase producers. [PDF]

Eur J Clin Microbiol Infect Dis
The carbapenemase-producing Gram-negative organisms represent an urgent clinical and public health concern, as they have been associated with increased mortality and high dissemination in healthcare settings.
Boattini M, Gaibani P, Comini S, Costa C, Cavallo R, Broccolo F, Bianco G.   +6 more
europepmc   +2 more sources

Increased zinc levels facilitate phenotypic detection of ceftazidime-avibactam resistance in metallo-β-lactamase-producing Gram-negative bacteria

Frontiers in Microbiology, 2022
Ceftazidime-avibactam is one of the last resort antimicrobial agents for the treatment of carbapenem-resistant, Gram-negative bacteria. Metallo-β-lactamase-producing bacteria are considered to be ceftazidime-avibactam resistant. Here, we evaluated a semi-
Michaela Simon, Michaela Simon, Roman G. Gerlach, Yvonne Pfeifer, Niels Pfennigwerth, Sören G. Gatermann, Agnes Schröder, Agnes Schröder, Andreas Hiergeist, Axel Hamprecht, Axel Hamprecht, Axel Hamprecht, Axel Hamprecht, Tamara Rügamer, André Gessner, Jonathan Jantsch, Jonathan Jantsch   +16 more
doaj   +1 more source

Analysis of the genes encoding the MBL-fold metallohydrolase superfamily proteins of the Pseudomonas putida BS3701 petroleum component-degrading strain [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2022
Objective. To determine whether the genes whose products are annotated as "MBL-fold metallohydrolase superfamily" are related to the proteins of the metallo-β-lactamase group. Materials and Methods.
Pozdnyakova-Filatova I.Yu., Zagoskin A.A., Zakharova M.V., Nagornykh M.O.   +3 more
doaj   +1 more source

The Revival of Aztreonam in Combination with Avibactam against Metallo-β-Lactamase-Producing Gram-Negatives: A Systematic Review of In Vitro Studies and Clinical Cases

Antibiotics, 2021
Infections caused by metallo-β-lactamase (MBL)-producing Enterobacterales and Pseudomonas are increasingly reported worldwide and are usually associated with high mortality rates (>30%).
Carola Mauri, A. Maraolo, Stefano Di Bella, F. Luzzaro, Luigi Principe   +4 more
semanticscholar   +1 more source

The urgent need for metallo-β-lactamase inhibitors: an unattended global threat

Lancet. Infectious Diseases (Print), 2021
Due to their superior tolerability and efficacy, β-lactams are the most potent and prescribed class of antibiotics in the clinic. The emergence of resistance to those antibiotics, mainly due to the production of bacterial enzymes called β-lactamases, has
M. Mojica, M. Rossi, A. Vila, R. Bonomo
semanticscholar   +1 more source

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors

Antibiotics, 2023
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors to counter this
Nakita Reddy, Letisha Girdhari, Mbongeni Shungube, Arnoldus C. Gouws, Byron K. Peters, Kamal K. Rajbongshi, Sooraj Baijnath, Sipho Mdanda, Thandokuhle Ntombela, Thilona Arumugam, Linda A. Bester, Sanil D. Singh, Anil Chuturgoon, Per I. Arvidsson, Glenn E. M Maguire, Hendrik G. Kruger, Thavendran Govender, Tricia Naicker   +17 more
doaj   +1 more source

Metallo-β Lactamase Producing Non-Fermentative Gram-Negative Bacilli from Various Clinical Isolates in a Tertiary Care Hospital: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association, 2021
Introduction: Non-fermentative gram-negative bacilli are common causes of human infections especially nosocomial infections. These organisms are usually resistant to multiple antimicrobial agents including carbapenems.
Mahendra Shrestha, Ratna Baral, Lok Bahadur Shrestha   +2 more
doaj   +1 more source