Results 61 to 70 of about 905,435 (191)

In Vitro Susceptibility of Aztreonam-Vaborbactam, Aztreonam-Relebactam and Aztreonam-Avibactam Associations against Metallo-β-Lactamase-Producing Gram-Negative Bacteria

Antibiotics, 2023
Background: Despite the availability of new options (ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam and cefiderocol), it is still very difficult to treat infections caused by metallo-β-lactamase (MBLs)-producers resistant to aztreonam.
Cécile Emeraud, Sandrine Bernabeu, Laurent Dortet   +2 more
doaj   +1 more source

Antarctic soil microbiomes encode structurally conserved and phylogenetically diverse beta‐lactamases

iMetaOmics, Volume 3, Issue 3, September 2026.
An integrative metagenomic framework combining sequence, structural, and functional inference reveals a phylogenetically diverse and structurally conserved repertoire of putative beta‐lactamases across Antarctic soil microbiomes, with predominance of class A and subclass B3 enzymes and limited but detectable associations with mobile genetic elements ...
José Coche‐Miranda, Patricio Arros, Nicolás Canales, Camilo Berríos‐Pastén, Gastón Azziz, Rosalba Lagos, Julieta Orlando, Francisco P. Chávez, Andrés E. Marcoleta   +8 more
wiley   +1 more source

Plasmid Profile Analysis and bla VIM Gene Detection of Metalo β-lactamase (MBL) Producing Pseudomonas aeruginosa Isolates from Clinical Samples [PDF]

Journal of Clinical and Diagnostic Research, 2014
Introduction: Pseudomonas aeruginosa is a frequent colonizer of hospitalized patients. They are responsible for serious infections such as meningitis, urological infections, septicemia and pneumonia.
Jayanthi S., Jeya M.
doaj   +1 more source

Investigating enzyme function by geometric matching of catalytic motifs

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The rapidly growing universe of predicted protein structures offers opportunities for data driven exploration but requires computationally scalable and interpretable tools. We developed a method to detect catalytic features in protein structures, providing insights into enzyme function and mechanism.
Raymund E. Hackett, Ioannis G. Riziotis, Martin Larralde, António J. M. Ribeiro, Georg Zeller, Janet M. Thornton   +5 more
wiley   +1 more source

Metagenomics Reveals Microbial Community Shifts Associated With Contrasting Anthropogenic Impacts in Freshwater Sources of A Coastal Protected Area in Southeastern Brazil

Water Environment Research, Volume 98, Issue 9, September 2026.
Metagenomics revealed distinct anthropogenic signatures in the microbiome of freshwater sources on Marambaia Island, supported by the Anthropogenic Impact Index (AII). Impacted sites showed lower microbial diversity, enrichment of fecal‐associated taxa, and 14 antimicrobial resistance genes, whereas conductivity, salinity, and turbidity explained 88.1%
Bruna Barbosa de Paula, Marize Pereira Miagostovich, Camille Ferreira Mannarino, André Vinicius Costa Ribeiro, Natália Maria Lanzarini, Carla Santos de Oliveira, Shênia Patrícia Corrêa Novo   +6 more
wiley   +1 more source

Epidemiology and Characteristics of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa [PDF]

, 2015
Metallo-β-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important nosocomial pathogen that shows resistance to all β-lactam antibiotics except monobactams.
이경원, 홍덕진, 정석훈
core   +1 more source

Inhibitory Potential of Polyclonal Camel Antibodies against New Delhi Metallo-β-lactamase-1 (NDM-1)

Molecules, 2020
New Delhi Metallo-β-lactamase-1 (NDM-1) is the most prevalent type of metallo-β-lactamase, able to hydrolyze almost all antibiotics of the β-lactam group, leading to multidrug-resistant bacteria.
Rahma Ben Abderrazek, Sarra Chammam, Ayoub Ksouri, Mariagrazia Perilli, Sayda Dhaouadi, Ines Mdini, Zakaria Benlasfar, Gianfranco Amicosante, Balkiss Bouhaouala-Zahar, Alessandra Piccirilli   +9 more
doaj   +1 more source

A Four‐Center Study on the Activity of Aztreonam and Aztreonam‐Avibactam Combination Against Clinical Isolates of Gram‐Negative Bacilli Producing Representatives of Ambler Class A, B, C or D β‐Lactamases

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT We aimed to investigate the activity of aztreonam and aztreonam‐avibactam combination against gram‐negative bacilli producing different types of β‐lactamases. Activity of aztreonam and aztreonam‐avibactam against 166 isolates (33 AmpC‐producing, 33 ESBL‐producing, 66 carbapenemase‐producing Enterobacterales, 34 metallo‐β‐lactamase‐producing P.
Gizem İnce Ceviz, Hasan Cenk Mirza, Aylin Üsküdar Güçlü, Özlem Öğüç Şanlı, Özlem Kurt Azap, Banu Sancak, Elvan Hortaç İştar, Ahmet Başustaoğlu   +7 more
wiley   +1 more source

Polypyridine ligands as potential metallo-β-lactamase inhibitors

, 2021
Bacteria have developed multiple resistance mechanisms against the most used antibiotics. In particular, zinc-dependent metallo-β-lactamase producing bacteria are a growing threat, and therapeutic options are limited ...
Viaggi, Valentina, Viale, Maurizio, La Piana L., Di Bella S., Viale M., Vecchio, Graziella, Luzzaro, Francesco, Luzzaro F., Di Bella, Stefano, Principe L., Viaggi V., Bertola N., Vecchio G., La Piana, Luana, Bertola, Nadia, Principe, Luigi   +15 more
core   +1 more source

Emergence and Polyclonal Dissemination of blaNDM-7–Carrying InX3 Plasmid in Enterobacter cloacae Complex, France, 2021–2023

Emerging Infectious Diseases
Among 3,367 New Delhi metallo-β-lactamase–producing Enterobacterales isolates collected in France during 2021–2023, we found the blaNDM-7 gene systematically localized on 2 closely related InX3 plasmids known to harbor antimicrobial resistance and ...
Ines Rezzoug, Delphine Girlich, Aurelien Birer, Richard Bonnet, Josephine Poiraud, Pierre Bogaerts, Cécile Emeraud, Laurent Dortet   +7 more
doaj   +1 more source