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It Takes Two to Tango: Current Understanding of the Role of M16 Family of Proteases and Their Structural Properties [PDF]
BiomoleculesThe M16 protease family comprises metalloendopeptidases, characterized by a unique molecular architecture. The active enzyme molecule is composed of two halves, which together form a structure resembling a clam shell.
Miroslaw Jarzab, Joanna Skorko-Glonek
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Production and application of peptidyl-lys metalloendopeptidase: advances, challenges, and future perspectives [PDF]
Applied Microbiology and BiotechnologyPeptidyl-lys metalloendopeptidases (PKMs) are enzymes that selectively cleave peptide bonds at the N-terminus of lysine residues present in the P1′ position, making them valuable tools in proteomics.
Uzair Ahmed +2 more
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Journal of Oral Biology and Craniofacial Research, 2023 Salivary gland (SG) extracellular matrix (ECM) has a major influence on tissue development, homeostasis, and tissue regeneration after injury. During aging, disease, and physical insult, normal remodeling of the SG microenvironment (i.e.
Milos Marinkovic +6 more
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gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. [PDF]
PLoS ONE, 2014 In order to sustain lifelong production of gametes, many animals have evolved a stem cell-based gametogenic program. In the Drosophila ovary, germline stem cells (GSCs) arise from a pool of primordial germ cells (PGCs) that remain undifferentiated even ...
Shinya Matsuoka +4 more
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Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
Toxins, 2016 The research on natural snake venom metalloendopeptidase inhibitors (SVMPIs) began in the 18th century with the pioneering work of Fontana on the resistance that vipers exhibited to their own venom.
Viviane A. Bastos +4 more
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Diagnostics, 2018 Campylobacters are major enteropathogens worldwide with a substantial financial burden. Matrix metalloproteinases (MMPs) are proteolytic metalloendopeptidases with ability to modify immune response and shown to be upregulated in patients with several ...
Anna Nilsson +5 more
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Journal of Genetic Engineering and Biotechnology, 2019 Background Serratiopeptidase is an alkaline metalloendopeptidase, which acquired wide significance because of its therapeutic applications.
Swathi Nageswara +2 more
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Frontiers in Ecology and Evolution, 2019 Pholcid spiders (Araneae: Pholcidae), officially “cellar spiders” but popularly known as “daddy long-legs,” are renown for the potential of deadly toxic venom, even though venom composition and potency has never formally been studied.
Pamela A. Zobel-Thropp +6 more
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The astacin family of metalloendopeptidases [PDF]
Protein Science, 1995 AbstractThe astacin family of metalloendopeptidases was recognized as a novel family of proteases in the 1990s. The crayfish enzyme astacin was the first characterized and is one of the smallest members of the family. More than 20 members of the family have now been identified.
J S, Bond, R J, Beynon
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Soluble Metalloendopeptidases and Neuroendocrine Signaling [PDF]
Endocrine Reviews, 2002 Peptidases play a vital and often highly specific role in the physiological and pathological generation and termination of peptide hormone signals. The thermolysin-like family of metalloendopeptidases involved in the extracellular processing of neuroendocrine and cardiovascular peptides are of particular significance, reflecting both their specificity ...
Corie N, Shrimpton +2 more
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