Results 71 to 80 of about 23,484 (216)

Mehr als nur ein biochemischer Puffer: Tris als Designer und Regulator einer Metall–Oxo‐Assemblierung

Angewandte Chemie, EarlyView.
Tris(hydroxymethyl)aminomethan – schematisch als Oktopus dargestellt – wirkt gleichzeitig als Alkoxy‐Ligand, Chelator und strukturleitender Puffer und programmiert in Wasser die Speziation, die Nukleation und die Heterometall‐Insertion von Polyoxometallaten. ZUSAMMENFASSUNG Polyoxometallate (POMs; molekulare Metall–Oxo‐Cluster) werden typischerweise in
Nadiia I. Gumerova, Annette Rompel
wiley   +1 more source

More Than a Buffer in Biochemistry: Tris as an Architect and Gatekeeper of Metal–Oxo Assembly

Angewandte Chemie International Edition, EarlyView.
Tris(hydroxymethyl)aminomethane, depicted as an octopus, acts as an alkoxy ligand, chelator, and structure‐directing buffer that programs polyoxometalate's speciation, nucleation, and heterometal insertion in aqueous solution. ABSTRACT Polyoxometalates (POMs, molecular metal–oxo clusters) are typically studied and applied in aqueous media, where ...
Nadiia I. Gumerova, Annette Rompel
wiley   +1 more source

On the singular, dual, and multiple positional specificity of manganese lipoxygenase and its G316A mutant

Journal of Lipid Research, 2007
manganese lipoxygenase (Mn-LO) oxygenates 18:3n-3 and 18:2n-6 to bis-allylic 11S-hydroperoxy fatty acids, which are converted to 13R-hydroperoxy fatty acids.
Mirela Cristea, Ernst H. Oliw
doaj   +1 more source

Influence of Zn2+ and Oxygen Supply on Malic Acid Production and Growth of Aspergillus oryzae

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Malic acid is a valuable platform chemical traditionally derived from fossil‐based resources. Microbial cultivation with Aspergillus oryzae offers a sustainable alternative based on renewable feedstocks. In this study, a well‐established minimal medium for malic acid production, commonly used in previous research to ensure reproducibility, was
Lukas Hartmann, Anke Neumann, Dirk Holtmann, Katrin Ochsenreither   +3 more
wiley   +1 more source

Carbonic Anhydrases: Role in pH Control and Cancer

Metabolites, 2018
The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new ...
Mam Y. Mboge, Brian P. Mahon, Robert McKenna, Susan C. Frost   +3 more
doaj   +1 more source

A quantum mechanical analysis of the light-harvesting complex 2 from purple photosynthetic bacteria. Insights into the electrostatic effects of transmembrane helices

, 2010
We perform a quantum mechanical study of the peptides that are part of the LH2 complex from Rhodopseudomonas acidophila, a non-sulfur purple bacteria that has the ability of producing chemical energy from photosynthesis.
Bryant, Cogdell, Cogdell, Cogdell, Cramer, Damjanović, Fabio Pichierri, Glaser, He, Herek, Hoff, Hol, Hu, Isaacs, Kjellberg, Klamt, Koepke, Linnanto, Nicholls, Papiz, Pichierri, Pichierri, Pichierri, Pichierri, Prince, Roszak, Scholes, Stewart, Stewart, Stewart, Stewart, Ullmann, van Oijen   +32 more
core   +1 more source

Layered double hydroxides‐based nanozymes for effective biomedical applications: A review and future perspectives

BMEMat, EarlyView.
In this review, we introduced the preparation methods of LDHzymes and discussed their catalytic activity and mechanisms. Subsequently, the applications of LDHzymes in biomedical were discussed. Finally, potential future work on LDHzymes was proposed to better design these new types of nanozymes.
Jiawei Cui, Lu Zhang, Junyi Li, Yue Chen, Sheng Dai, Manfred F. Maitz, Ansha Zhao, Ping Yang   +7 more
wiley   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica with Amino Acids and Amines

Metabolites, 2019
The β-carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic protozoan Entamoeba histolytica, EhiCA, was investigated for its activation with a panel of natural and non-natural amino acids and amines. EhiCA was potently activated by D-His, D-Phe, D-
Silvia Bua, Susanna Haapanen, Marianne Kuuslahti, Seppo Parkkila, Claudiu T. Supuran   +4 more
doaj   +1 more source

Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3

Frontiers in Pharmacology, 2020
Ectonucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of nucleoside tri- and di-phosphates to mono-phosphates. The products are subsequently hydrolyzed by ecto-5′-nucleotidase (ecto-5′-NT) to nucleosides.
Younis Baqi, Mahmoud Rashed, Laura Schäkel, Enas M. Malik, Julie Pelletier, Jean Sévigny, Jean Sévigny, Amelie Fiene, Christa E. Müller   +8 more
doaj   +1 more source