Results 51 to 60 of about 108,904 (277)
Pediatrics and Neonatology, 2016 Methanol poisoning is rare in the pediatric population, but a delay in diagnosis and intervention may cause severe morbidity and mortality. The current therapy for methanol poisoning is ethanol or fomepizole, which acts as a competitive inhibitor of ...
Tzu-Hua Chen +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Bioresources and Bioprocessing, 2017 Background Methanol is regarded as a biorenewable platform feedstock because nearly all bioresources can be converted into methanol through syngas.
Xiaolu Wang +7 more
doaj +1 more source
Lanthanide-Dependent Methanol and Formaldehyde Oxidation in Methylobacterium aquaticum Strain 22A
Microorganisms, 2020 Lanthanides (Ln) are an essential cofactor for XoxF-type methanol dehydrogenases (MDHs) in Gram-negative methylotrophs. The Ln3+ dependency of XoxF has expanded knowledge and raised new questions in methylotrophy, including the differences in ...
Patcha Yanpirat +8 more
doaj +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Purification and properties of methanol dehydrogenase and aldehyde dehydrogenase from Methylobacillus glycogenes. [PDF]
Agricultural and Biological Chemistry, 1990 Methanol dehydrogenase (MDH) and aldehyde dehydrogenase (ALDH) were purified to a homogenous state from Methylobacillus glycogenes, an obligate methylotroph. MDH (Mr 140,000) was composed of two different subunits (Mr 60,000 and 9,000) forming an α2β2 structure.
ADACHI, Osao +3 more
openaire +2 more sources
Assessing Lanthanide-Dependent Methanol Dehydrogenase Activity: The Assay Matters
ChemBioChem, 2023 Abstract Artificial dye-coupled assays have been widely adopted as a rapid and convenient method to assess the activity of methanol dehydrogenases (MDH). Lanthanide(Ln)-dependent XoxF-MDHs from methanotrophs and methylotrophs are able to incorporate different lanthanides (Lns) in their active site.
Manh Tri Phi +6 more
openaire +4 more sources
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
The Amino Acid Sequence of the Methanol Dehydrogenase
, 2013 Methanol dehydrogenase (69 kDa; EC 1.1.99.8) was identified as one of the peptides recognized by the patient plasma. Amino acids in red represent sequences that were matched during peptide mass fingerprinting.
David E Kleiner (16246) +12 more
core +1 more source