Results 31 to 40 of about 10,041 (230)

Biased Metropolis Sampling for Rugged Free Energy Landscapes [PDF]

, 2003
Metropolis simulations of all-atom models of peptides (i.e. small proteins) are considered. Inspired by the funnel picture of Bryngelson and Wolyness, a transformation of the updating probabilities of the dihedral angles is defined, which uses ...
Berg, Bernd A.
core   +3 more sources

Targeted Cell Reprogramming Produces Analgesic Chromaffin-Like Cells from Human Mesenchymal Stem Cells

Cell Transplantation, 2013
Transplantation of allogeneic adrenal chromaffin cells demonstrated the promise of favorable outcomes for pain relief in patients. However, there is a very limited availability of suitable human adrenal gland tissues, genetically well-matched donors in ...
T. Qu M.D., Ph.D., G. Shi, K. Ma, H. N. Yang, W. M. Duan, G. D. Pappas   +5 more
doaj   +1 more source

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain [PDF]

, 2017
Background: Neuropeptide precursors are traditionally viewed as proteins giving rise to small neuropeptide molecules. Prodynorphin (PDYN) is the precursor protein to dynorphins, endogenous ligands for the kappa-opioid receptor.
Alkass, Kanar, Andersson, Malin, Bakalkin, Georgy, Bazov, Igor, Druid, Henrik, Dyachok, Oleg, Gerashchenko, Ganna, Kononenko, Olga, Krishtal, Oleg, Mulder, Jan, Rajkowska, Grazyna, Stockmeier, Craig A, Svenningsen, Asa Fex, Verbeek, Dineke S., Watanabe, Hiroyuki, Yakovleva, Tatiana   +15 more
core   +2 more sources

Methionine-Enkephalin in Bone and Joint Tissues [PDF]

Journal of Bone and Mineral Research, 1998
Abstract Methionine-enkephalin (met-enk), an endogenous opiate, mimics many of the effects of morphine by binding to opiate receptors, thereby eliciting similar cellular and behavioral effects. Using biochemical and immunohistochemical techniques, several peptides have been identified in bone and joint tissues.
A M, Elhassan, J U, Lindgren, K, Hultenby, J, Bergstrom, A, Adem   +4 more
openaire   +2 more sources

Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels in Vitro

Cell Transplantation, 2006
We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya, Tingyu Qu, Kiminobu Sugaya, George D. Pappas   +3 more
doaj   +1 more source

Serotoninergic, peptidergic and GABAergic innervation of the ventrolateral and dorsolateral motor nuclei in the cat S1/S2 segments: An immunofluorescence study [PDF]

, 1994
Indirect single- and double-staining immunofluorescence techniques were used to study the serotoninergic, peptidergic and GABAergic innervation of the ventrolateral (Onuf's nucleus) and dorsolateral (innervating intrinsic foot sole muscles) nuclei ...
Arvidsson, U. (U.), Hökfelt, T. (T.), Ramírez-León, V. (V.), Ulfhake, B. (B.), Verhofstad, A.A. (Albert), Visser, T.J. (Theo)   +5 more
core   +1 more source

How Far Does a Receptor Influence Vibrational Properties of an Odorant? [PDF]

, 2016
The biophysical mechanism of the sense of smell, or olfaction, is still highly debated. The mainstream explanation argues for a shape-based recognition of odorant molecules by olfactory receptors, while recent investigations suggest the primary olfactory
Kongsted, Jacob, List, Nanna Holmgaard, Reese, Anna, Solov'yov, Ilia A   +3 more
core   +10 more sources

Hyperpolarization Modulation of the T-Type hCa_v3.2 Channel by Human Synenkephalin [1-53], a Shrew Neurotoxin Analogue without Paralytic Effects. [PDF]

Angew Chem Int Ed Engl
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Fukuoka R, Yano Y, Hara N, Sadamoto C, Maturana AD, Kita M.   +5 more
europepmc   +2 more sources

Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis

Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.
This review provides a comprehensive account of the use of backbone N‐protecting groups in peptide synthesis. It includes detailed synthetic methods relating to their introduction and removal and their application to “difficult” peptides and proteins of biological significance in both academic and industry contexts.
Samuel J. Paravizzini, Linda M. Haugaard‐Kedström, Craig A. Hutton, John A. Karas   +3 more
wiley   +2 more sources

Biomimetic Chemistry on Tandem Protein/Lipid Damages under Reductive Radical Stress

CHIMIA, 2008
The study of radical stress in the biological environment needs a comprehensive vision of all possible reactive species and their mechanisms. Among them, reductive stress is evaluated for its selective target of sulfur-containing compounds.
Sílvia Atrian, Krzysztof Bobrowski, Mercè Capdevila, Chryssostomos Chatgilialoglu, Carla Ferreri, Chantal Houée-Levin, Anna Maria Salzano, Andrea Scaloni, Armida Torreggiani   +8 more
doaj   +1 more source