Results 11 to 20 of about 348,762 (206)

Impact of Methionine Synthase Reductase Polymorphisms in Chronic Myeloid Leukemia Patients. [PDF]

Genes (Basel), 2022
Introduction： Metabolism methionine and of folate play a vital function in cellular methylation reactions, DNA synthesis and epigenetic process.However, polymorphisms of methionine have received much attention in recent medical genetics research. Objectives: To ascertain whether the common polymorphisms of the MTRR (Methionine Synthase Reductase) A66G ...
Elderdery AY, Tebein EM, Alenazy FO, Elkhalifa AME, Shalabi MG, Abbas AM, Alhassan HH, Davuljigari CB, Mills J.   +8 more
europepmc   +4 more sources

Methylenetetrahydrofolate reductase and methionine synthase: biochemistry and molecular biology [PDF]

European Journal of Pediatrics, 1998
Methylenetetrahydrofolate reductase and cobalamin-dependent methionine synthase catalyze the penultimate and ultimate steps in the biosynthesis of methionine in prokaryotes, and are required for the regeneration of the methyl group of methionine in mammals. Defects in either of these enzymes can lead to hyperhomocysteinemia.
Matthews, R. G., Sheppard, Christal A., Goulding, C.   +2 more
openaire   +5 more sources

Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk

Leukemia Research, 2008
We tested whether the polymorphisms of the methylenetetrahydrofolate reductase gene, MTHFR C677T and A1298C, the methionine synthase gene, MTR A2756G, the methionine synthase reductase gene, MTRR A66G, and the thymidylate synthase gene, TYMS 2R-->3R, involved in folate and methionine metabolism, altered the risk for multiple myeloma (MM).
Carmen S P, Lima, Manoela M, Ortega, Margareth C, Ozelo, Renato C, Araujo, Cármino A, De Souza, Irene, Lorand-Metze, Joyce M, Annichino-Bizzacchi, Fernando F, Costa   +7 more
core   +4 more sources

The Polymorphisms in Methylenetetrahydrofolate Reductase, Methionine Synthase, Methionine Synthase Reductase, and the Risk of Colorectal Cancer [PDF]

International Journal of Biological Sciences, 2012
Polymorphisms in genes involved in folate metabolism may modulate the risk of colorectal cancer (CRC), but data from published studies are conflicting. The current meta-analysis was performed to address a more accurate estimation.
Daijun Zhou, Qiang Mei, Han Luo, Bo Tang, Peiwu Yu
doaj   +4 more sources

Antimalarial target vulnerability of the putative Plasmodium falciparum methionine synthase [PDF]

PeerJ
Background Plasmodium falciparum possesses a cobalamin-dependent methionine synthase (MS). MS is putatively encoded by the PF3D7_1233700 gene, which is orthologous and syntenic in Plasmodium.
Nirut Leela, Parichat Prommana, Sumalee Kamchonwongpaisan, Tana Taechalertpaisarn, Philip J. Shaw   +4 more
doaj   +3 more sources

An infant with an extremely rare cobalamin disorder: Methionine synthase deficiency and importance of early diagnosis and treatment [PDF]

The Turkish Journal of Pediatrics, 2019
Functional methionine synthase deficiency can be separated into two classes, cobalamin (Cbl) deficiency type E (CblE) and type G (CblG), which are the result of mutations that affect methionine synthase reductase or methionine synthase, respectively ...
Çiğdem Seher Kasapkara, Ebru Yılmaz-Keskin, Ferda Özbay-Hoşnut, Meltem Akçaboy, Emine Polat, Asburçe Olgaç, Pelin Zorlu   +6 more
doaj   +2 more sources

Association of methionine synthase (rs1805087), methionine synthase reductase (rs1801394), and methylenetetrahydrofolate dehydrogenase 1 (rs2236225) genetic polymorphisms with recurrent implantation failure

Human Fertility, 2019
One-carbon metabolism, in which folate plays an essential role, is important for maintaining pregnancy and foetal development. Here, polymorphisms in three genes involved in the methylation of homocysteine were examined: methionine synthase (MTR), methionine synthase reductase (MTRR), and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), each of ...
Sung Hwan, Cho, Ji Hyang, Kim, Hui Jeong, An, Jung Oh, Kim, Young Ran, Kim, Woo Sik, Lee, Nam Keun, Kim   +6 more
openaire   +3 more sources

Effect of methionine synthase A2756G and methionine synthase reductase A66G gene polymorphisms in male infertility

Türk Üroloji Dergisi/Turkish Journal of Urology, 2011
Objective: In this study, we investigated whether methionine synthase (MTR) A2756G and methionine synthase reductase (MTRR) A66G gene polymorphisms were related with infertility.
Ali Sahin Kucukaslan, Rasit Altintas, Vildan Bozok Cetintas, Asli Tetik, Murat Ulukus, Bulent Semerci, Zuhal Eroglu   +6 more
openaire   +2 more sources

The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women

Cancer Causes & Control, 2009
The purpose of the study was to investigate the association between cervical cancer risk and single-nucleotide polymorphisms (SNPs) in three one-carbon metabolism genes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) in Korean women. Twelve SNPs were identified in MTHFR, MTR, and MTRR in
Seo-Yun, Tong, Jong-Min, Lee, Eun-Seop, Song, Kwang-Beom, Lee, Mi-Kyung, Kim, Young Mi, Yun, Jae-Kwan, Lee, Sung-Kyong, Son, Jung-Pil, Lee, Jae-Hoon, Kim, Soo-Young, Hur, Yong-Il, Kwon   +11 more
core   +5 more sources

Distribution of Methionine Synthase Reductase (MTRR) Gene A66G Polymorphism in Indian Population. [PDF]

Indian J Clin Biochem, 2021
Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine pathway. It is responsible for regulation of methionine enzyme by reductive methylation. A common variant A66G is reported in the FMN-binding domain of the MTRR gene, which leads to substitution of isoleucine by methionine (I22M) in MTRR enzyme with reduced activity.
Yadav U, Kumar P, Rai V.
europepmc   +4 more sources