Biochemistry, 2004 Human methionine synthase reductase (MSR) is a protein containing both FAD and FMN, and it reactivates methionine synthase that has lost activity due to oxidation of cob(I)alamin to cob(II)alamin. In this study, anaerobic redox titrations were employed to determine the midpoint reduction potentials for the flavin cofactors in two highly prevalent ...
Olteanu, Horatiu +4 more
openaire +4 more sources
A study into the cobalamin-dependent methionine synthase reactivation mechanism in corynebacterium glutamicum [PDF]
, 2009 PhDMethionine is one of the seven essential amino-acids for humans and is also used in feed supplements, predominantly for poultry and felines. Thus there is commercial interest in producing this nutrient. The final step in the biological synthesis of
Burton-Smith, Raymond Nathaniel
core +4 more sources
Methylenetetrahydrofolate Reductase and Methionine Synthase Reductase Polymorphisms: Genetic Predictors of Congenital Heart Disease Subtypes. [PDF]
CureusThe objective of this study was to investigate the association of methylenetetrahydrofolate reductase (MTHFRc.677C>T)and methionine synthase reductase (MTRR c.66A>G) genetic polymorphisms with the occurrence of congenital heart disease (CHD) and its subtypes in children.This was a hospital-based case-control which included patients aged 0-11 months ...
Tripathi S +4 more
europepmc +3 more sources
Human methionine synthase reductase is a molecular chaperone for human methionine synthase [PDF]
Proceedings of the National Academy of Sciences, 2006 Sustained activity of mammalian methionine synthase (MS) requires MS reductase (MSR), but there have been few studies of the interactions between these two proteins. In this study, recombinant human MS (hMS) and MSR (hMSR) were expressed in baculovirus-infected insect cells and purified to homogeneity.
Kazuhiro, Yamada +3 more
openaire +2 more sources
The role of homocysteine and methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase polymorphisms in the development of cardiovascular diseases and hypertension [PDF]
Orvosi Hetilap, 2012 Cardiovascular diseases (CVDs) are the leading causes of death in the developed countries. Elevated homocysteine level is as an independent risk factor of CVDs. The C677T and A1298C variants of methylenetetrahydrofolate reductase gene (MTHFR) have been shown to influence folate and homocysteine metabolisms.
Krisztina, Marosi +6 more
openaire +2 more sources
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Analysis of methionine synthase reductase polymorphism (A66G) in Indian Muslim population. [PDF]
Indian J Hum Genet, 2013 Methionine synthase reductase (MTRR) is a vital enzyme of homocysteine/methionine metabolic pathway and is required for the conversion of inactive form of methionine synthase (MTR) to its active form. A clinically important allelic variant of MTRR A66G, with less enzymatic activity is reported with worldwide prevalence rate of ~ 30%.
Rai V, Yadav U, Kumar P, Yadav SK.
europepmc +4 more sources
Human Methionine Synthase Reductase, a Soluble P-450 Reductase-like Dual Flavoprotein, Is Sufficient for NADPH-dependent Methionine Synthase Activation [PDF]
Journal of Biological Chemistry, 2001 Methionine synthase is a key enzyme in the methionine cycle that catalyzes the transmethylation of homocysteine to methionine in a cobalamin-dependent reaction that utilizes methyltetrahydrofolate as a methyl group donor. Cob(I)alamin, a supernucleophilic form of the cofactor, is an intermediate in this reaction, and its reactivity renders the enzyme ...
H, Olteanu, R, Banerjee
openaire +2 more sources
, 2003 Elevation in the plasma level of homocysteine, a sulfur-containing amino acid, has been identified as a risk factor for cardiovascular disease, neural tube defects, and Alzheimer's disease.
Hall, Diane Anita
core +4 more sources
Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. [PDF]
PLoS ONE, 2015 Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The mechanisms by which these are affected in NAFLD are not fully understood.
Tommy Pacana +7 more
doaj +1 more source