Results 21 to 30 of about 369,868 (397)
A Rare Case of Methotrexate Induced Pancreatitis in Ectopic Pregnancy
The Ewha Medical Journal, 2023 Ectopic pregnancy (EP) refers to blastocyst implantation outside the uterine endometrium. EP is major cause of maternal morbidity and mortality. Treatment options include surgery, medical therapy with methotrexate,
Jiwon Choi +4 more
doaj +1 more source
Harmine Has Nephroprotective Effect Against Methotrexate-Induced Injury in Mice via Inhibition of Oxidative Stress [PDF]
Research Journal of Pharmacognosy, 2021 Background and objectives: Despite clinical use, the efficacy of methotrexate is often limited by some adverse effects, mainly nephrotoxicity. The most common mechanism of methotrexate-induced kidney damages is oxidative stress.
Cyrus Jalili +5 more
doaj +1 more source
EFFICACY OF FUROSEMIDE IN METHOTREXATE CLEARANCE IN PATIENTS TREATED WITH HIGH DOSE METHOTREXATE
Hematology, Transfusion and Cell Therapy, 2022 Objective: Methotrexate was first used in 1947 as a chemotherapeutic drug in the treatment of acute lymphoblastic leukemia (ALL). Methotrexate has been extensively explored as an anticancer drug since that time.
Saqib Khan +2 more
doaj +1 more source
Rheumatology and Therapy, 2023 Introduction One target of rheumatoid arthritis (RA) treatment is to achieve early sustained remission; over the long term, patients in sustained remission have less structural joint damage and physical disability.
Paul Emery +14 more
doaj +1 more source
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients [PDF]
, 2016 Purpose: Methotrexate administration is associated with frequent adverse neurological events during treatment for childhood acute lymphoblastic leukemia.
Baird, Susan F. +5 more
core +2 more sources
Low‐Dose Methotrexate for the Prevention of Atherosclerotic Events
New England Journal of Medicine, 2019 BACKGROUND Inflammation is causally related to atherothrombosis. Treatment with canakinumab, a monoclonal antibody that inhibits inflammation by neutralizing interleukin‐1β, resulted in a lower rate of cardiovascular events than placebo in a previous ...
P. Ridker +25 more
semanticscholar +1 more source
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. [PDF]
, 2004 BACKGROUND: An open-label study indicated that selective depletion of B cells with the use of rituximab led to sustained clinical improvements for patients with rheumatoid arthritis. To confirm these observations, we conducted a randomized, double-blind,
Close, DR +7 more
core +1 more source
International Journal of Molecular Sciences, 2020 Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune diseases.
P. Koźmiński +3 more
semanticscholar +1 more source
Clinics, 2016 OBJECTIVE: To test the hypothesis that intravenous use of methotrexate associated with lipid nanoemulsions can achieve superior anti-inflammatory effects in the joints of rabbits with antigen-induced arthritis compared with commercial methotrexate ...
Suzana B.V. Mello +4 more
doaj +1 more source
Geraniol Averts Methotrexate-Induced Acute Kidney Injury via Keap1/Nrf2/HO-1 and MAPK/NF-κB Pathways
Current Issues in Molecular Biology, 2021 Objectives: Geraniol, a natural monoterpene, is an essential oil component of many plants. Methotrexate is an anti-metabolite drug, used for cancer and autoimmune conditions; however, clinical uses of methotrexate are limited by its concomitant renal ...
N. Younis +3 more
semanticscholar +1 more source