Results 21 to 30 of about 283,343 (354)

METHOTREXATE USE IS SAFE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Folia Medica Indonesiana, 2017
Monitoring level of methotrexate is not only aimed at monitoring effectiveness, but also safety aspects of the administration of high-dose methotrexate because the use of high-dose methotrexate is one of the problems associated with toxicity in various ...
Febriansyah Nur Utomo, Yulistiani Yulistiani, Nun Zairina, Bambang Permono   +3 more
doaj   +1 more source

Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/β-catenin signaling in methotrexate-induced rat ileal mucositis

Journal of Pharmacological Sciences, 2022
This study aimed to elucidate the role of nitric oxide (NO) in intestinal stem cells in methotrexate-induced ileal mucositis in rats. Methotrexate induced the mRNA expressions of the Wnt/β-catenin target genes Wnt3a, Sox9, and Lgr5 and the Wnt-antagonist
Maiko Machida, Takuji Machida, Masaki Kikuchi, Ayaka Shimizu, Syunsuke Ida, Yoshiki Tawaraya, Risa Kato, Keisuke Haramaki, Kaori Yama, Saki Shiga, Masahiko Hirafuji, Kenji Iizuka   +11 more
doaj   +1 more source

Intravitreal Methotrexate

Journal of Ophthalmic and Vision Research, 2021
Intravitreal methotrexate (MTX) has been proven to be an effective treatment for various intraocular diseases. In this article, a comprehensive review was performed on intravitreal applications of methotrexate. Different aspects of the administration of intravitreal MTX for various clinical conditions such as intraocular tumors, proliferative ...
Fatemeh Abdi, S. Saeed Mohammadi, Khalil Ghasemi Falavarjani   +2 more
openaire   +4 more sources

Disease activity and cognition in rheumatoid arthritis : an open label pilot study [PDF]

, 2012
Acknowledgements This work was supported in part by NIHR Newcastle Biomedical Research Centre. Funding for this study was provided by Abbott Laboratories.
Birchall, Daniel, Blamire, Andrew M, He, Jiabao, Isaacs, John D, Newton, Julia L, Pearce, Ruth, Raftery, Graham   +6 more
core   +1 more source

Failure Rate of Single Dose Methotrexate in Managment of Ectopic Pregnancy

Obstetrics and Gynecology International, 2015
Background. One of the treatment modalities for ectopic pregnancy is methotrexate. The purpose of this study is to identify the failure rate of methotrexate in treating patients with ectopic pregnancy as well as the risk factors leading to treatment ...
Feras Sendy, Eman AlShehri, Amani AlAjmi, Elham Bamanie, Surekha Appani, Taghreed Shams   +5 more
doaj   +1 more source

Rheumatoid arthritis [PDF]

, 2016
Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability. Early diagnosis is key to optimal therapeutic success, particularly in patients with well-characterised risk factors for poor ...
Aletaha, Daniel, McInnes, Iain B., Smolen, Josef S.   +2 more
core   +1 more source

Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

Asian Journal of Pharmaceutical Sciences, 2017
The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.
Huiyan Shi, Chenzhi Hou, Liqiang Gu, Zhe Wei, Hang Xing, Meiyu Zhang, Shixiao Wang, Longshan Zhao, Kaishun Bi, Xiaohui Chen   +9 more
doaj   +1 more source

Tumor necrosis factor inhibitors in psoriatic arthritis. [PDF]

, 2017
INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially.
Kraft, Walter K., Mantravadi, Santhi, Ogdie, Alexis   +2 more
core   +2 more sources

Effects of intraventricular methotrexate administration on Cuprizone-induced demyelination in mice

Frontiers in Molecular Neuroscience, 2013
We previously showed that intrathecal administration of methotrexate slowed disability progression in multiple sclerosis patients with progressive disease. In general MS patients with progressive disease respond poorly to anti-inflammatory therapies.
Andre Michael Mueller, Adam eNassery, Hana eConlon, Xinhe eLiu, Massimiliano eCristofanilli, Esther eJun, Bo Hyung eYoon, Saud Ahmed Sadiq   +7 more
doaj   +1 more source

The role of nitric oxide in small intestine differs between a single and a consecutive administration of methotrexate to rats

Journal of Pharmacological Sciences, 2020
The role of nitric oxide (NO) on intestinal mucosal injury induced by single or consecutive administration of methotrexate was investigated in a rodent model. Rats received methotrexate intraperitoneally either as a single administration (50 mg/kg) or as
Saki Shiga, Takuji Machida, Takumi Yanada, Maiko Machida, Masahiko Hirafuji, Kenji Iizuka   +5 more
doaj   +1 more source