Results 21 to 30 of about 247,722 (198)

Adverse Effects of Low-Dose Methotrexate

Annals of Internal Medicine, 2020
Background Low-dose methotrexate (LD-MTX) is the most commonly used drug for systemic rheumatic diseases worldwide and is the recommended first-line agent for rheumatoid arthritis.
D. Solomon, R. Glynn, E. Karlson, Fengxin Lu, Cassandra Corrigan, J. Colls, Chang Xu, Jean G Macfadyen, M. Barbhaiya, N. Berliner, P. Dellaripa, Brendan M. Everett, A. Pradhan, S. Hammond, M. Murray, Deepak A. Rao, S. Ritter, Anna E. Rutherford, J. Sparks, J. Stratton, Dong-Hyun Suh, S. Tedeschi, K. Vanni, N. Paynter, P. Ridker   +24 more
semanticscholar   +1 more source

EXACERBATION OF ANKYLOSING SPONDYLITIS AFTER LOW-DOSE METHOTREXATE THERAPY

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Efficacy of methotrexate in ankylosing spondylitis (AS) is disputable. Nevertheless, methotrexate is still used for disease-modifying therapy of AS. Aim: To assess efficacy and safety of methotrexate in AS patients.
A. V. Orlov-Morozov
doaj   +1 more source

Medical system error causing methotrexate poisoning and delay in diagnosis: report of two cases

Journal of Emergency Practice and Trauma, 2021
Objective: We are going to alert the emergency physicians to be aware of drugs side effects. Some drugs like methotrexate are not routine drugs, and the symptoms may be miss diagnosed if not completely notified.
Hamidreza Reihani
doaj   +1 more source

METHOTREXATE USE IS SAFE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Folia Medica Indonesiana, 2017
Monitoring level of methotrexate is not only aimed at monitoring effectiveness, but also safety aspects of the administration of high-dose methotrexate because the use of high-dose methotrexate is one of the problems associated with toxicity in various ...
Febriansyah Nur Utomo, Yulistiani Yulistiani, Nun Zairina, Bambang Permono   +3 more
doaj   +1 more source

Methotrexate treatment in early psoriatic arthritis in comparison to rheumatoid arthritis: an observational nationwide study

RMD Open, 2023
Introduction We aimed to compare the proportions of patients with newly diagnosed psoriatic arthritis (PsA) and rheumatoid arthritis (RA) remaining on methotrexate (regardless of other disease-modifying antirheumatic drug (DMARD)-changes), and ...
Ulf Lindström, Tor Olofsson, Lennart Jacobsson, Daniela Di Giuseppe, Eva Klingberg, Sofia Exarchou, Gerd-Marie Alenius, Johan K Wallman   +7 more
doaj   +1 more source

Failure Rate of Single Dose Methotrexate in Managment of Ectopic Pregnancy

Obstetrics and Gynecology International, 2015
Background. One of the treatment modalities for ectopic pregnancy is methotrexate. The purpose of this study is to identify the failure rate of methotrexate in treating patients with ectopic pregnancy as well as the risk factors leading to treatment ...
Feras Sendy, Eman AlShehri, Amani AlAjmi, Elham Bamanie, Surekha Appani, Taghreed Shams   +5 more
doaj   +1 more source

Impact of Bosentan in Ameliorating Methotrexate-Induced Tongue Toxicity in Rats [PDF]

المجلة العراقية للصيدلة
Background and objective: Although methotrexate has been utilized over many years, adverse effects are frequent throughout therapy, especially among cancer patients.
Rana Khairi Attarbashee
doaj   +1 more source

A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate.

New England Journal of Medicine, 1999
BACKGROUND Patients treated with methotrexate for rheumatoid arthritis often improve but continue to have active disease. This study was undertaken to determine whether the addition of etanercept, a soluble tumor necrosis factor receptor (p75):Fc fusion ...
M. Weinblatt, J. Kremer, A. Bankhurst, K. Bulpitt, R. Fleischmann, Robert I. Fox, C. G. Jackson, M. Lange, D. Burge   +8 more
semanticscholar   +1 more source

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

Leukemia, 2020
Folate metabolism enables cell growth by providing one-carbon (1C) units for nucleotide biosynthesis. The 1C units are carried by tetrahydrofolate, whose production by the enzyme dihydrofolate reductase is targeted by the important anticancer drug ...
J. García-Cañaveras, Olga Lancho, Gregory S. Ducker, J. Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, S. Minuzzo, S. Indraccolo, Hahn Kim, D. Herranz, J. Rabinowitz   +10 more
semanticscholar   +1 more source

Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

Asian Journal of Pharmaceutical Sciences, 2017
The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.
Huiyan Shi, Chenzhi Hou, Liqiang Gu, Zhe Wei, Hang Xing, Meiyu Zhang, Shixiao Wang, Longshan Zhao, Kaishun Bi, Xiaohui Chen   +9 more
doaj   +1 more source