Results 201 to 210 of about 292,501 (293)

Design eines aus der Fettsäuresynthase der Maus abgeleiteten Multienzyms für die kompartimentierte chemo‐enzymatische Synthese von 2‐Pyron‐Polyketiden

Angewandte Chemie, EarlyView.
Die 4‐Cumarate‐Ligase (4CL1) aus Piper methysticum wurde mit einer nicht‐reduzierenden murinen Fettsäuresynthase verknüpft. Eine direkte Acylierung des ACP durch 4CL1 wurde beobachtet. Die Ketosynthase (KS) wurde so verändert, dass sie das nicht‐kanonische Zimtsäure‐Substrat akzeptiert.
Felix Lehmann, Nadja Joachim, Carolin Parthun, Martin Grininger   +3 more
wiley   +1 more source

Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening

Angewandte Chemie, EarlyView.
Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler, Ingrid Richter, Katharina Dornblut, Alicia Scharf, Christian Hertweck   +4 more
wiley   +2 more sources

"Two scoops, please!": Twin cryo-EM structures of an Arabidopsis thaliana DNA methyltransferase. [PDF]

Plant Cell
Hübbers JW.
europepmc   +1 more source

The metabolic consequences of mouse betaine homocysteine S-methyltransferase deficiency

, 2011
Ya‐Wen Teng
openalex   +2 more sources

RNMT-dependent RNA cap methylation in health and disease. [PDF]

Biochem J
Mills JG, Hepburn LA, Cowling VH.
europepmc   +1 more source

Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites

Cell, 2002
B. Czermin, R. Melfi, D. Mccabe, Volker Seitz, A. Imhof, V. Pirrotta   +5 more
semanticscholar   +1 more source

Design, synthesis and biological evaluation of new non-nucleosidic inhibitors od DNA methyltransferases

, 2013
Monica Viviano
openalex   +1 more source

Catechol-O-methyltransferase polymorphism modulates cognitive control in children with chromosome 22q11.2 deletion syndrome [PDF]

, 2009
Yukari Takarae, Linda C. Schmidt, Flora Tassone, T.J. Simon   +3 more
openalex   +1 more source

Fluorescent Probes Derived from the Polyene Class of Antifungal Drugs Reveal Distinct Localization Patterns and Resistance‐Associated Vacuolar Sequestration in Candida Species

Angewandte Chemie, EarlyView.
Fluorescent probes derived from all three clinically used polyene antifungals (amphotericin B, nystatin, and natamycin) enabled direct visualization of distribution in yeast cells of various Candida species. While retaining the ergosterol‐dependent mode of action of their parent drugs, the probes revealed distinct, structure‐specific localization ...
Melissa Shbeta, Tal Kopp, Ivan Voronov, Adi Yona, Rania Hasib Afana, Shmuel Carmeli, Micha Fridman   +6 more
wiley   +2 more sources

Transcription, Maturation and Degradation of Mitochondrial RNA: Implications for Innate Immune Response. [PDF]

Biomolecules
Yan C, Yu J, Lyu H, Xiao S, Guo D, Zhang Q, Zhang R, Tang J, Song Z, Zhou C.   +9 more
europepmc   +1 more source