Results 221 to 230 of about 292,501 (293)

The Parkinson's Disease Drug Tolcapone and Analogues are Potent Glycomimetic Lectin Inhibitors of Pseudomonas aeruginosa LecA

Angewandte Chemie International Edition, EarlyView.
We present Tolcapone and derivatives as a new class of potent glycomimetics for lectin inhibition. Over 3200 Roche in‐house compounds were screened experimentally and a subset was biophysically evaluated. Our findings show the potential to develop potent non‐carbohydrate glycomimetic lectin inhibitors, opening a path toward innovative anti‐infective ...
Steffen Leusmann, Eike Siebs, Sakonwan Kuhaudomlarp, Annabelle Varrot, Anne Imberty, Bernd Kuhn, Christian Lerner, Uwe Grether, Alexander Titz   +8 more
wiley   +1 more source

Peripheral Blood Expression of MMPs and DNA Methylation-Related Genes in Women with Recurrent Spontaneous Abortion: A Case-Control Study. [PDF]

F1000Res
Imani M, Zare F, Hadinedoushan H, Rahmani F, Fesahat F.   +4 more
europepmc   +1 more source

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

Cellular and Molecular Life Sciences, 2015
Nicole Stopa, J. Krebs, D. Shechter
semanticscholar   +1 more source

Immediate Reward Bias in Humans: Fronto-Parietal Networks and a Role for the Catechol-O-Methyltransferase 158^Val/ValGenotype [PDF]

, 2007
Charlotte A. Boettiger, Jennifer Mitchell, Venessa C. Tavares, Margaret Robertson, Geoff Joslyn, Mark D’Esposito, Howard L. Fields   +6 more
openalex   +1 more source

Design of a Multienzyme Derived from Mouse Fatty Acid Synthase for the Compartmentalized Production of 2‐Pyrone Polyketides

Angewandte Chemie International Edition, EarlyView.
A multienzyme was formed and evaluated by covalently linking 4‐coumarate ligase (4CL1) from Piper methysticum to a non‐reducing murine fatty acid synthase. 4CL1 acylates the acyl carrier protein (ACP). The ketosynthase (KS) was engineered to accept the non‐native cinnamoyl substrate, which is elongated by malonyl‐CoA loaded via the malonyl‐acetyl ...
Felix Lehmann, Nadja Joachim, Carolin Parthun, Martin Grininger   +3 more
wiley   +1 more source

Phospho-Switch: Regulation of the Activity of SAM-Dependent Methyltransferases Using <i>H</i>-Phosphinic SAM Analogue. [PDF]

Int J Mol Sci
Filonov VL, Khomutov MA, Rudenko AY, Mariasina SS, Ozhiganov RM, Sergeev AV, Kochetkov SN, Polshakov VI, Gromova ES, Khandazhinskaya AL, Khomutov AR.   +10 more
europepmc   +1 more source

Characterisation of the N‐Methyltransferase SgPsmC: Application in the Kinetic Resolution of Pyrroloindolines

Angewandte Chemie International Edition, EarlyView.
The N‐methyltransferase SgPsmC was characterised and applied in the kinetic resolution (KR) of easily obtainable pyrroloindolines. Substitution at 3a‐position proved to be a principal determinant for the enzyme's enantioselectivity. While moving toward laboratory scale, the reaction was coupled with a methionine adenosyl transferase for in situ ...
Benjamin Panagiotis Chapple, Lia Nitz, Pascal Schneider, Birgit Henßen, Sebastian Myllek, Mona Haase, Thomas Classen, Jörg Pietruszka   +7 more
wiley   +1 more source

The SNHG3/miR-148a-3p axis-mediated high expression of DNMT1 is correlated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma. [PDF]

J Gastrointest Oncol
Yao N, Qu G, Shi Y, Miao H, Sun G, Sun J, Zheng W, Zhao H.   +7 more
europepmc   +1 more source

Epitranscriptomic signatures in blood: emerging biomarkers for diagnosis of diabetes and its complications. [PDF]

Front Cell Dev Biol
Hlavackova M, Benak D, Holzerova K, Alanova P, Hrdlicka J, Chalupova M, Opletalova B, Ostadal B, Kolar F.   +8 more
europepmc   +1 more source

Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters DNA methyltransferase (dnmt) expression in zebrafish (Danio rerio)

, 2015
Neelakanteswar Aluru, Elaine Y. Kuo, Lily W. Helfrich, Sibel I. Karchner, Elwood Linney, June E. Pais, Diana G. Franks   +6 more
openalex   +1 more source