Results 1 to 10 of about 12,400 (143)

Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA

PLoS Biology, 2022
N6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes degradation of transcripts encoding proteins that have roles in cell development, differentiation, and other pathways. METTL3 is the major methyltransferase that catalyzes the
Hui Xian Poh, Aashiq H. Mirza, Brian F. Pickering, Samie R. Jaffrey   +3 more
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Regulation of Methylase METTL3 on Fat Deposition

Diabetes, Metabolic Syndrome and Obesity, 2021
Gang Luo, Jialing Chen, Zhanjun Ren College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People’s Republic of ChinaCorrespondence: Zhanjun RenCollege of Animal Science and Technology, Northwest A&F University ...
Luo G, Chen J, Ren Z
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TBK1-METTL3 Axis Facilitates Antiviral Immunity [PDF]

SSRN Electronic Journal, 2021
mRNA m6A modification is heavily involved in modulation of immune responses. However, its function in antiviral immunity is controversial, and how immune responses regulate m6A modification remains elusive. We here find TBK1, a key kinase of antiviral pathways, phosphorylates the core m6A methyltransferase METTL3 at serine 67. The phosphorylated METTL3
Jingxuan, Chen, Xuemei, Wei, Xiao, Wang, Tong, Liu, Yingchi, Zhao, Luoying, Chen, Yujie, Luo, Hongqiang, Du, Yunfei, Li, Tongtong, Liu, Lili, Cao, Zhe, Zhou, Zeming, Zhang, Ling, Liang, Lu, Li, Xuhui, Yan, Xuehui, Zhang, Xuliang, Deng, Guang, Yang, Ping, Yin, Jianlei, Hao, Zhinan, Yin, Fuping, You   +22 more
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7SK methylation by METTL3 promotes transcriptional activity [PDF]

Science Advances, 2023
A fundamental feature of cell signaling is the conversion of extracellular signals into adaptive transcriptional responses. The role of RNA modifications in this process is poorly understood. The small nuclear RNA 7SK prevents transcriptional elongation by sequestering the cyclin dependent kinase 9/cyclin T1 (CDK9/CCNT1) positive ...
Marcelo Perez-Pepe, Anthony W. Desotell, Hengyi Li, Wenxue Li, Bing Han, Qishan Lin, Daryl E. Klein, Yansheng Liu, Hani Goodarzi, Claudio R. Alarcón   +9 more
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A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

eLife, 2023
N 6 -methyladenosine (m 6 A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3–METTL14 heterodimers and Wilms’ tumor 1-associated protein (WTAP), contributes to ...
Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang   +12 more
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METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury [PDF]

Neurospine, 2023
Objective Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA.
Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Liu   +9 more
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METTL3 regulates WTAP protein homeostasis [PDF]

Cell Death & Disease, 2018
AbstractThe Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Sorci, Melissa, Ianniello, Zaira, Cruciani, Sonia, Larivera, Simone, Ginistrelli, Lavinia Ceci, Capuano, Ernestina, Marchioni, Marcella, Fazi, Francesco, Fatica, Alessandro   +8 more
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METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10

Cancer Cell International, 2022
Objective N6-methyladenosine (m6A) RNA methylation is involved in governing the mechanism of tumor progression. We aimed to excavate the biological role and mechanism of the m6A methyltransferase METTL3 in cholangiocarcinoma (CCA).
Jingli Cai, Zheng Cui, Jingyi Zhou, Bosen Zhang, Ruiqi Lu, Youcheng Ding, Hai Hu   +6 more
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Mining for METTL3 inhibitors to suppress cancer

Nature Structural & Molecular Biology, 2021
The RNA methyltransferase METTL3 catalyzes N6-methyladenosine (m6A) modification of messenger RNAs (mRNAs). It is overexpressed in many types of cancer, including acute myelogenous leukemia (AML), and promotes cancer cell growth and tumorigenicity. Now, a selective small molecule inhibitor of METTL3 shows significant antileukemic effects in preclinical
Jiazhi Li, Richard I. Gregory
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Comprehensive analysis of m6A methylomes in idiopathic pulmonary arterial hypertension

Epigenetics, 2023
Idiopathic pulmonary arterial hypertension (IPAH) is a serious and fatal disease. Recently, m6A has been reported to play an important role in the lungs of IPAH patients and experimental pulmonary hypertension models. However, the meaning of m6A mRNAs in
Ting Huang, Yunhong Zeng, Yao Yang, Haoqin Fan, Youcai Deng, Wenjuan Chen, Jinqiao Liu, Fan Yang, Wenfeng Li, Yunbin Xiao   +9 more
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