Results 121 to 130 of about 12,400 (143)

The Regulatory Role of m⁶A Modification in the Function and Signaling Pathways of Animal Stem Cells. [PDF]

Cells
Yang X, Xu Y, Zhu S, Wang M, Cao H, Lu L.   +5 more
europepmc   +1 more source

Emerging roles of RNA m⁶A modification in multiple myeloma pathogenesis and treatment resistance (Review). [PDF]

Int J Oncol
Maimaitiyiming Y, Hu S, Bai D, Guan Y, Bu N, Hao W, Maimaiti M.   +6 more
europepmc   +1 more source

METTL3-mediated m⁶A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca²⁺ signaling. [PDF]

Mol Cancer
Chen C, Xiong K, Liang F, Zhong Y, Qin X, Huang N, Fang Y, Zhu B, Cheng J, Wei Q, Zheng L, Zhao J.   +11 more
europepmc   +1 more source

IGF2BP3-STAT3-METTL3 axis promotes malignant progression in hepatocellular carcinoma (HCC). [PDF]

Hum Genomics
Xu Y, Cao Y, Yang J, Yu X, Yang L, Xie Y, Zhao J, Zhang Y.   +7 more
europepmc   +1 more source

m⁶A modification and SUMOylation of PHGDH regulates ulcerative colitis through autophagy. [PDF]

Cell Mol Life Sci
Xue H, Wang D, Pang C, Shen Y, Xu J, Zhang L.   +5 more
europepmc   +1 more source

miR-101/METTL3 axis induces autophagy by interrupting FOXG1/EIF3J-AS1 binding in gliomas. [PDF]

Cell Death Dis
Yan Y, Liu S, Luo A, Cai M, Zhang X, Liu X, Xu Y, Su Y, Zhang S, Liu J, Liu X.   +10 more
europepmc   +1 more source

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UVB promotes melanogenesis by regulating METTL3

Journal of Cellular Physiology, 2023
AbstractUltraviolet (UV) radiation is the primary exogenous inducer of skin pigmentation, although the mechanism has not been fully elucidated. N6‐methyladenosine (m6A) modification is one of the key epigenetic form of gene regulation that affects multiple biological processes.
Haoran Guo, Hongliang Zeng, Yibo Hu, Ling Jiang, Li Lei, Jinhua Hung, Chuhan Fu, Hui Li, Yan Long, Jing Chen, Qinghai Zeng   +10 more
openaire   +2 more sources

The Mettl3 epitranscriptomic writer amplifies p53 stress responses

Molecular Cell, 2022
The p53 transcription factor drives anti-proliferative gene expression programs in response to diverse stressors, including DNA damage and oncogenic signaling. Here, we seek to uncover new mechanisms through which p53 regulates gene expression using tandem affinity purification/mass spectrometry to identify p53-interacting proteins.
Nitin Raj, Mengxiong Wang, Jose A. Seoane, Richard L. Zhao, Alyssa M. Kaiser, Nancie A. Moonie, Janos Demeter, Anthony M. Boutelle, Craig H. Kerr, Abigail S. Mulligan, Clare Moffatt, Shelya X. Zeng, Hua Lu, Maria Barna, Christina Curtis, Howard Y. Chang, Peter K. Jackson, Laura D. Attardi   +17 more
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METTL3 is required for maintaining β-cell function

Metabolism, 2021
N6-methyladenosine (m6A) mRNA methylation has been shown to regulate obesity and type 2 diabetes. However, whether METTL3, the key methyltransferase for m6A mRNA methylation, regulates β-cell failure in diabetes has not been fully explored. Here, we show that METTL3 is downregulated under the inflammatory and oxidative stress conditions, and islet β ...
Xinzhi, Li, Yuze, Jiang, Xu, Sun, Yongsen, Wu, Zheng, Chen   +4 more
openaire   +2 more sources