Results 11 to 20 of about 12,400 (143)

The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation [PDF]

Open Biology, 2017
Myogenic progenitor/stem cells retain their skeletal muscle differentiation potential by maintaining myogenic transcription factors such as MyoD. However, the mechanism of how MyoD expression is maintained in proliferative progenitor cells has not been ...
Kensuke Kudou, Tetsuro Komatsu, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara, Yasuyuki Ohkawa   +8 more
doaj   +1 more source

METTL3/m6A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma

Frontiers in Pharmacology, 2022
Epigenetic regulation plays a critical role in the development, progression, and treatment of tumors. The most common chemical modification of mRNA, called m6A, is essential for controlling mRNA stability, splicing, and translation.
Fangfang Ge, Fangfang Ge, Zhenyu Li, Zhenyu Li, Jiaru Hu, Youguang Pu, Fangfang Zhao, Lingsuo Kong   +7 more
doaj   +1 more source

METTL3 regulates heterochromatin in mouse embryonic stem cells [PDF]

Nature, 2021
METTL3 (methyltransferase-like 3) mediates the N6-methyladenosine (m6A) methylation of mRNA, which affects the stability of mRNA and its translation into protein1. METTL3 also binds chromatin2-4, but the role of METTL3 and m6A methylation in chromatin is not fully understood. Here we show that METTL3 regulates mouse embryonic stem-cell heterochromatin,
Wenqi Xu, Jiahui Li, Chenxi He, Jing Wen, Honghui Ma, Bowen Rong, Jianbo Diao, Liyong Wang, Jiahua Wang, Feizhen Wu, Li Tan, Yujiang Geno Shi, Yang Shi, Hongjie Shen   +13 more
openaire   +2 more sources

The catalytic mechanism of the RNA methyltransferase METTL3

eLife, 2023
The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme that deposits N6-methyladenosine (m6A) modifications on messenger RNA (mRNA) in humans. METTL3-14 plays key roles in various biological processes through its methyltransferase (MTase) activity.
Corbeski, Ivan, Vargas-Rosales, Pablo Andrés, Bedi, Rajiv Kumar, Deng, Jiahua, Coelho, Dylan, Braud, Emmanuelle, Iannazzo, Laura, Li, Yaozong, Huang, Danzhi, Ethève-Quelquejeu, Mélanie, Cui, Qiang, Caflisch, Amedeo   +11 more
openaire   +4 more sources

METTL3 regulates breast cancer-associated alternative splicing switches

Oncogene, 2022
ABSTRACTAlternative splicing (AS) enables differential inclusion of exons from a given transcript, thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play major roles in the development of different pathologies, including breast cancer.N6-methyladenosine (m6A), the most abundant internal modification of eukaryotic ...
Cyrinne Achour, Paula Groza, Devi Prasad Bhattarai, Ángel-Carlos Román, Francesca Aguilo   +4 more
openaire   +3 more sources

The methyltransferase METTL3 promotes tumorigenesis via mediating HHLA2 mRNA m6A modification in human renal cell carcinoma

Journal of Translational Medicine, 2022
Background As an important N6-methyladenosine (m6A) regulator, abnormal expression of methyltransferase-like protein 3 (METTL3) has been reported in certain human cancers.
Dawei Zhu, Yingting Liu, Junjun Chen, Qi Wang, Yuan Li, Yulan Zhu, Jun Feng, Jingting Jiang   +7 more
doaj   +1 more source

METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis

Journal of Experimental & Clinical Cancer Research, 2022
Background Colorectal carcinoma (CRC) is the third most common cancer and second most common cause of cancer-related deaths worldwide. Ribonucleic acid (RNA) N6-methyladnosine (m6A) and methyltransferase-like 3 (METTL3) play key roles in cancer ...
Jiashu Pan, Feng Liu, Xiaoli Xiao, Ruohui Xu, Liang Dai, Mingzhe Zhu, Hanchen Xu, Yangxian Xu, Aiguang Zhao, Wenjun Zhou, Yanqi Dang, Guang Ji   +11 more
doaj   +1 more source

Mettl3 promotes oxLDL‐mediated inflammation through activating STAT1 signaling [PDF]

Journal of Clinical Laboratory Analysis, 2021
Abstract Background Atherosclerosis (AS) is the main cause of cerebrovascular diseases, and macrophages act important roles during the AS pathological process through regulating inflammation. Modification of the novel N(6)‐methyladenine (m6A) RNA is reported to be associated with AS, but its ...
Zhenwei Li, Qingqing Xu, Ning Huangfu, Xiaomin Chen, Jianhua Zhu   +4 more
openaire   +3 more sources

Analysis of METTL3 and METTL14 in hepatocellular carcinoma

Aging, 2020
N6-methyladenosine (m6A) RNA methylation is the most prevalent modification of messenger RNAs (mRNAs) and catalyzed by a multicomponent methyltransferase complex (MTC), among which methyltransferase-like 3 (METTL3) and METTL14 are two core molecules. However, METTL3 and METTL14 play opposite regulatory roles in hepatocellular carcinoma (HCC).
Liu, Xiangxiang, Qin, Jian, Gao, Tianyi, Li, Chenmeng, Chen, Xiaoxiang, Zeng, Kaixuan, Xu, Mu, He, Bangshun, Pan, Bei, Xu, Xueni, Pan, Yuqin, Sun, Huiling, Xu, Tao, Wang, Shukui   +13 more
openaire   +2 more sources

METTL3 stabilizes HDAC5 mRNA in an m6A-dependent manner to facilitate malignant proliferation of osteosarcoma cells

Cell Death Discovery, 2022
Osteosarcoma (OS) is a prevalent primary bone sarcoma. Methyltransferase-like 3 (METTL3) is dysregulated in human malignancies. This study explored the mechanism of METTL3 in OS cell proliferation.
Renbing Jiang, Zhibing Dai, Junshen Wu, Suzhi Ji, Yachao Sun, Wenpeng Yang   +5 more
doaj   +1 more source