Results 31 to 40 of about 12,400 (143)
Cell Reports, 2023 Summary: While a few works have shown that Mettl3 plays oncogenic roles in hepatocellular carcinoma (HCC), its function in early HCC tumorigenesis remains unclear.
Tao Wei +15 more
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METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer
Frontiers in Oncology, 2022 The role of methyltransferase-like 3 (METTL3), which participates in catalyzing N-methyladenosine (m6A) RNA modification, in gastric cancer (GC) is unclear. Here, we found that METTL3 was overexpressed in human GC.
Nuofan Wang +7 more
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METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
Open MedicineOverexpression of methyltransferase-like 3 (METTL3) is significantly correlated with the malignancy of lung cancer (LC). In the present study, we demonstrated that METTL3 had higher levels in LC tissues relative to normal tissues.
Zhang Peng +5 more
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Frontiers in OncologyIntroductionThis study aims to investigate the role of the m6A regulatory factor METTL3 in LUAD.MethodsBy examining the expression of METTL3 in LUAD and conducting cellular functional experiments, the biological functions of METTL3 were discussed.
Shaoting Chen +6 more
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Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages
Leukemia, 2023 Recent efforts in understanding the epitranscriptome have shown that a diverse set of modifications to RNA represent a new pervasive mechanism of gene regulation, with roles in stem cell homeostasis and disease. N6-methyladenosine (m6A) is an evolutionarily conserved RNA modification and one of the most abundant found on polyadenylated RNA(1,2).
Sturgess, Katherine +15 more
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Roles of METTL3 in cancer: mechanisms and therapeutic targeting [PDF]
Journal of Hematology & Oncology, 2020 AbstractN6-methyladenosine (m6A) is the most abundant mRNA modification and is catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is the sole catalytic subunit. Accumulating evidence in recent years reveals that METTL3 plays key roles in a variety of cancer types, either dependent or independent on its m6A RNA ...
Chengwu Zeng +3 more
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M6A Methyltransferase METTL3 Modulates Traumatic Brain Injury by Targeting Ferroptosis
Frontiers in Bioscience-LandmarkBackground: Traumatic brain injury (TBI) is a disease caused by external forces that damage brain structure and function. After TBI, iron accumulation and reactive oxygen species (ROS) increase lipid peroxidation, promoting ferroptosis.
Fei Qin +5 more
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Cancer Management and Research, 2020 Tian-Liang Xia,* Shu-Mei Yan,* Li Yuan, Mu-Sheng Zeng State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China*These authors ...
Xia TL, Yan SM, Yuan L, Zeng MS
doaj
Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer [PDF]
Journal of Hematology & Oncology, 2020 AbstractGastrointestinal cancer, the most common solid tumor, has a poor prognosis. With the development of high-throughput sequencing and detection technology, recent studies have suggested that many chemical modifications of human RNA are involved in the development of human diseases, including cancer.
Qiang Wang +6 more
openaire +3 more sources
Molecular MedicineBackground Pancreatic cancer is highly lethal, and METTL3 plays a crucial role in the regulation of m6A. However, the therapeutic potential of METTL3 in pancreatic cancer is unclear.
Qiuhong Wang +10 more
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