Results 41 to 50 of about 12,400 (143)

Research Progress on Methyltransferase-like Protein 3 in Progression of Aerobic Glycolysis in Gastrointestinal Tumors

Zhongliu Fangzhi Yanjiu
Metabolic reprogramming is one of the significant characteristics of malignant tumor development. It provides the tumor with sufficient energy and materials. During the process by which tumor cells acquire metabolic reprogramming, epigenetic changes play
Deyuan MA, Na WANG, Huiqiang WANG, Quanlin GUAN   +3 more
doaj   +1 more source

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification

Cancer Cell International, 2022
Background N6-methyladenosine (m6A) has emerged as a significant regulator of the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains unclear.
Yiming Xu, Dandan Lv, Chao Yan, Hua Su, Xue Zhang, Yangfeng Shi, Kejing Ying   +6 more
doaj   +1 more source

METTL3 modulates m6A modification of CDC25B and promotes head and neck squamous cell carcinoma malignant progression

Experimental Hematology & Oncology, 2022
Background N6-methyladenosine (m6A) RNA methylation and its methyltransferase METTL3 have been widely reported to be involved in different cancers by regulating RNA metabolism and function.
Yu-qing Guo, Qiang Wang, Jun-guo Wang, Ya-jun Gu, Pan-pan Song, Shou-yu Wang, Xiao-yun Qian, Xia Gao   +7 more
doaj   +1 more source

The Role of RNA Methyltransferase METTL3 in Normal and Malignant Hematopoiesis

Frontiers in Oncology, 2022
m6A modification is the most common modification in eukaryotes. METTL3, as a core methyltransferase of m6A modification, plays a vital role in normal and malignant hematopoiesis.
Xia Wu, Wu Ye, Yuping Gong
doaj   +1 more source

METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4

Frontiers in Bioscience-Landmark
Background: Osteosarcoma cells are prone to metastasis, and the mechanism of N6-methyladenosine (m6A) methylation modification in this process is still unclear.
Xi-song Huo, Dan Lu, Da-gui Chen, Min Ye, Xiao-wei Wang, Fu-sheng Shang   +5 more
doaj   +1 more source

METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246

Cell Death Discovery, 2021
Ovarian cancer is a common gynecological malignant tumor with a high mortality rate and poor prognosis. There is inadequate knowledge of the molecular mechanisms underlying ovarian cancer.
Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yang   +7 more
doaj   +1 more source

METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification

Frontiers in Cell and Developmental Biology, 2022
Background: Osteosarcoma (OS) is the most prevalent bone cancer among children and adolescents, with relatively high mortality rates. RNA N6-methyladenosine (m6A) is the most common human mRNA modification with diverse functions in a variety of ...
Xinying Zhou, Yang Yang, Yuejun Li, Guojun Liang, Dawei Kang, Bing Zhou, Qingchu Li   +6 more
doaj   +1 more source

METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2

Open Medicine
We aimed to explore the regulatory effects of methyltransferase-like 3 (METTL3) on diabetic retinopathy (DR) by regulating the m6A modification of SOX2 mRNA and elucidating the underlying molecular mechanism.
Chen Xiujuan, Ling Qipeng, Xu Jie, Ye Yunyao, Dong Lili   +4 more
doaj   +1 more source

METTL3 expression is associated with glycolysis metabolism and sensitivity to glycolytic stress in hepatocellular carcinoma

Cancer Medicine, 2020
METTL3 is an RNA methyltransferase implicated in the control of cell differentiation and proliferation in embryonic development and cancer. The current study was aimed to explore the function and underlying mechanism of METTL3 in hepatocellular carcinoma
Ye Lin, Xiangling Wei, Zhixiang Jian, Xuewen Zhang   +3 more
doaj   +1 more source

METTL3 suppresses neuropathic pain via modulating N6-methyladenosine-dependent primary miR-150 processing

Cell Death Discovery, 2022
Methyltransferase-like 3 (METTL3)-modulated N6-methyladenosine (m6A) was recently identified as an important epigenetic regulation type during RNA processing and contributes to multiple pathological processes. Neuropathic pain (NP) is induced by a lesion
Le Zhang, Xin Zhao, Jing Wang, Yanwu Jin, Moxuan Gong, Yuyang Ye, Peilong Li   +6 more
doaj   +1 more source