Results 51 to 60 of about 12,400 (143)

Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation [PDF]

Cell Research, 2017
METTL3 catalyzes the formation of N6-methyl-adenosine (m6A) which has important roles in regulating various biological processes. However, the in vivo function of Mettl3 remains largely unknown in mammals. Here we generated germ cell-specific Mettl3 knockout mice and demonstrated that Mettl3 was essential for male fertility and spermatogenesis.
Kai, Xu, Ying, Yang, Gui-Hai, Feng, Bao-Fa, Sun, Jun-Qing, Chen, Yu-Fei, Li, Yu-Sheng, Chen, Xin-Xin, Zhang, Chen-Xin, Wang, Li-Yuan, Jiang, Chao, Liu, Ze-Yu, Zhang, Xiu-Jie, Wang, Qi, Zhou, Yun-Gui, Yang, Wei, Li   +15 more
openaire   +2 more sources

USP25 deubiquitinates cytosolic METTL3 to impede glioma proliferation via an m6A-independent pathway

iScience
Summary: METTL3 exhibits distinct tumorigenic roles in the nucleus and cytoplasm, but whether its post-transcriptional modifications vary by subcellular localization remains unclear.
Bingchang Zhang, Wanhong Han, Xin Gao, Wenhua Li, Jianhua Yu, Wujie Zhao, Jiawei He, Xiansheng Qiu, Zhenwei Lu, Liwei Zhou, Yahui Hu, Yuanyuan Xie, Yanyan Geng, Hanwen Lu, Wentao Zhao, Xinwen Liao, Shouren Chen, Xiyao Liu, Sifang Chen, Guowei Tan, Yaya Zhang, Zhanxiang Wang   +21 more
doaj   +1 more source

miR-212-5p inhibits nasopharyngeal carcinoma progression by targeting METTL3

Open Medicine, 2022
This study was conducted to investigate the effect of microRNA-212-5p (miR-212-5p) on the proliferation and apoptosis of nasopharyngeal carcinoma (NPC) cells.
Zhou Hongyu, Zhang Nana
doaj   +1 more source

METTL3 Potentiates M2 Macrophage‐Driven MMT to Aggravate Renal Allograft Fibrosis via the TGF‐β1/Smad3 Pathway

Advanced Science
METTL3, a key enzyme in N6‐methyladenosine (m6A) modification, plays a crucial role in the progression of renal fibrosis, particularly in chronic active renal allograft rejection (CAR).
Qinfan Yao, Xiaoxiao Zheng, Xinyi Zhang, Yucheng Wang, Qin Zhou, Junhao Lv, Li Zheng, Jiahua Lan, Wei Chen, Jianghua Chen, Dajin Chen   +10 more
doaj   +1 more source

Regulatory role of the METTL3/MALAT1 axis in multiple myeloma progression

Journal of Bone Oncology
Objective: Methyltransferase-like 3 (METTL3) plays a crucial role in cancer progression, both in m6A modification-dependent and −independent pathways. We aimed to elucidate the mechanism by which METTL3 and the long noncoding RNA metastasis-associated ...
Xiaohong Lu, Yafei Li, Ruie Li, Jingheng Zhang, Jiayu Peng, Yan Zhang   +5 more
doaj   +1 more source

METTL3 facilitates the progression of cervical cancer by m6A modification-mediated up-regulation of NEK2

Scientific Reports
N6-methyladenosine (m6A) is the most prevalent modification found in eukaryotic RNA and played a significant role in various cancers. However, the mechanism by which m6A modification influences cervical cancer (CC) tumorigenesis remains unclear ...
Yilin Guo, Yangyang Bai, Lu Wang, Zhen Xu, Nan Zhang, Wuliang Wang, Hu Zhao   +6 more
doaj   +1 more source

Reciprocal METTL3-PAX5 regulation in maintaining B-cell identity and promoting B-cell hyperreactivity in SLE

Molecular Medicine
Objective METTL3, an m6A methyltransferase, enhances germinal center responses. This study explores its role in lupus B cells and its impact on B-cell activation.
Yiying Yang, Ying Zhang, Shasha Xie, Ke Liu, Meidong Liu, Yisha Li, Hui Luo, Xiaoxia Zuo, Huali Zhang, Muyao Guo   +9 more
doaj   +1 more source

METTL3-mediated miR-4534 maturation promotes IVDD progression by targeting the Sirt6-mediated Nrf2/HO-1 pathway

Archives of Medical Science
Introduction Intervertebral disc degeneration (IVDD) is a significant contributor to the development of discogenic low back pain and impairment. Apoptosis and degradation of the extracellular matrix (ECM) have also been reported to be major factors in ...
Bo Ran, Ziqing Yang, Mengzhao Li
doaj   +1 more source

CircABCC1 reduces endometrial receptivity via METTL3/FAM155B axis

The Journal of Maternal-Fetal & Neonatal Medicine
Impaired endometrial receptivity is the main cause of embryo implantation failure. Little information is available on the role of circRNAs in endometrial receptivity. Here, the effect of circABCC1 on endometrial receptivity and its mechanism were investigated.GEO database was screened for key biomarkers for recurrent implantation failure (RIF ...
Lan, Luo, Mi, Tang, Licen, Xie, Xi, Chen, Donghong, Ning, Qiuman, Zheng, Qin, Cao, Ziting, Ouyang   +7 more
openaire   +2 more sources

Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis

Frontiers in Bioscience-Landmark
Background: Endometriosis is a complicated and enigmatic disease that significantly diminishes the quality of life for women affected by this condition.
Fang Li, Hua Tao, Yini Wei, Ru Meng, Yushan Li, Lifang Nie, Yu Zhang, Jinjun Chang   +7 more
doaj   +1 more source