Results 61 to 70 of about 12,400 (143)

METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis

Clinical Epigenetics
Abstract Background Periodontitis is a highly prevalent oral disease characterized by bacterium-induced periodontal inflammation and alveolar bone destruction. Osteoblast function is impaired in periodontitis with a global proteome change.
Yiwen Zhang, Yiping Kong, Wenjie Zhang, Jinlin He, Zhanqi Zhang, Yongjie Cai, Yiqing Zhao, Qiong Xu   +7 more
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The METTL3/m6A Reader Protein YTHDF1 Regulates Endothelial Cell Pyroptosis by Enhancing NLRP3 Expression to Affect Soft Tissue Injury

Journal of Inflammation Research
Xuesong Xie,1 Fang Fang2 1Department of Orthopedics, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of China; 2Department of Anorectal, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of ChinaCorrespondence: Fang Fang ...
Xie X, Fang F
doaj  

METTL3-Mediated N6-Methyladenosine Ferroptosis in Sepsis-Associated Acute Lung Injury — A Narrative Review

Frontiers in Bioscience-Landmark
Sepsis-induced acute lung injury (ALI) represents a complex and life-threatening condition with limited therapeutic options. Recent research has unveiled the role of methyltransferase-like 3 (METTL3)-mediated N6-methyladenosine (m6A) modifications in ...
Rinki Kumari, Roger Leng, Brian Chiu, Consolato M. Sergi   +3 more
doaj   +1 more source

METTL3 Promotes mRNA Translation to Drive Tumorigenesis [PDF]

Cancer Discovery, 2018
Abstract METTL3 interacts with eIF3h to enhance the translation efficiency of target mRNAs including BRD4.
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Decreased METTL3 in atrial myocytes promotes atrial fibrillation

Europace
Abstract Aims Methyltransferase like 3 (METTL3) plays a crucial role in cardiovascular diseases, but its involvement in atrial fibrillation (AF) remains unclear.
Jian Shi, Xi-Yu Zhu, Rong-Huang Yu, Wen-Xue Liu, Jie Yang, Lu Tang, Chui-Yu Kong, Han-Qing Luo, Fen Chen, Wen-Sen Xie, Jia-Lei Fu, Jing-Jie Wang, Qian Zhou, Qing Zhou, Dong-Jin Wang   +14 more
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METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients

Open Medicine
N6-methyladenosine (m6A) is the most frequently occurring interior modification in eukaryotic messenger RNA (mRNA), and abnormal mRNA modifications can affect many biological processes.
Tan Quandan, Yang Le, Yuan Shanshan, Zheng Danni, Lin Yapeng, Chen Kejie, He Ying, Chen Shuntian, Hao Junli, Dai Jin, He Song, Mao Fengkai, Leng Xinyi, Jiang Haisong, Yang Jie   +14 more
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Author Response: A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

, 2023
Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang   +12 more
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Compound 21 Attenuates Isoflurane-Induced Injury in Neonatal Rat Hippocampal Neurons and Primary Rat Neuronal Cells by Upregulating METTL3

Journal of Inflammation Research
Yaping Shen,1,2,* Yijiu Wu,3,* Hai Zhuang,4 Zhumei Chen,5 Qiong Zhang,5 Peixin Li,5 Jing Wang,3 Zhi Huang,1 Qingfan Zeng3,5 1Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550002, People’s ...
Shen Y, Wu Y, Zhuang H, Chen Z, Zhang Q, Li P, Wang J, Huang Z, Zeng Q   +8 more
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METTL3 facilitates renal cell carcinoma progression by PLOD2 m6A-methylation under prolonged hypoxia

Cell Death and Disease
N6-methyladenosine (m6A) is the most prevalent reversible modification in eukaryotic mRNA, and it plays a critical role in tumor progression. The purpose of this study was to investigate the function and regulatory mechanisms of the methyltransferase ...
Yimeng Chen, Yichen He, Zhengsheng Li, Nan Zhang, Cuixing Zhou, Xiaozhou He, Dong Xue   +6 more
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Coilin mediates m6A RNA methylation through phosphorylation of METTL3

Biology Open, 2023
Douglas M. McLaurin, Sara K. Tucker, Michael D. Hebert   +2 more
doaj   +1 more source