Results 111 to 120 of about 30,985 (250)
The FEBS Journal, EarlyView.Some prenylated flavin mononucleotide (prFMN) synthases exceptionally prefer dimethylallyl phosphate (DMAP) over dimethylallyl diphosphate (DMAPP), which is a common prenyl donor substrate for many prenyltransferases. Structural and mutagenic analyses of Methanosarcina mazei prFMN synthase, which prefers DMAP but can also accept DMAPP, elucidated its ...
Sou Fukuhara +5 more
wiley +1 more source
Bakuchiol: From structural mimicry to systems‐level skin biology
International Journal of Cosmetic Science, EarlyView.Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley +1 more source
Journal of Lipid Research, 1981 Circulating mevalonate is metabolized by two mechanisms: the sterol pathways leading to cholesterol and the shunt pathway resulting in CO2 production. The kidney is the chief site of circulating mevalonate metabolism by both pathways.
K R Feingold +3 more
doaj +1 more source
Negative regulation of cell proliferation by mevalonate or one of the mevalonate phosphates.
Journal of Biological Chemistry, 1991 The role of mevalonate and its products in the regulation of cellular proliferation was examined using 6-fluoromevalonate (Fmev), a compound that blocks the conversion of mevalonate pyrophosphate to isopentenyl pyrophosphate. Fmev suppressed DNA synthesis by a variety of transformed and malignant T cell, B cell, and myeloid cell lines.
J A, Cuthbert, P E, Lipsky
openaire +2 more sources
Tissue Resident Memory Cells: Friend or Foe?
Immunology, EarlyView.Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude +2 more
wiley +1 more source
Metabolism of plasma mevalonate in rats and humans.
Journal of Lipid Research, 1982 A circadian rhythm in plasma mevalonate was identified in human subjects. This variation, over a 5-fold range, is paralleled by a rhythm in urinary excretion.
R R Kopito +4 more
doaj +1 more source
Chemistry of mevalonic acid [PDF]
Biochemical Journal, 1969 J W, Cornforth, R H, Cornforth
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Effects of mevalonate (MEV) on bacterial killing by simvastatin.
, 2013 Different concentrations of mevalonate (0.6 mM–10 mM) were incubated with S. pneumoniae alone or together with simvastatin (15.6 µg/ml or 36 µmol/L) or with DMSO (2.5%).
Anton Pohanka (345489) +7 more
core +1 more source
Journal of Internal Medicine, EarlyView.Abstract Background AA amyloidosis (AAA) remains a life‐threatening yet largely preventable complication of monogenic autoinflammatory diseases (AIDs). Methods We retrospectively described patients with AAA secondary to one of the four historical monogenic AIDs (familial Mediterranean fever [FMF], cryopyrin‐associated periodic syndrome [CAPS ...
Majdouline El Moussaoui +11 more
wiley +1 more source
Mevalonate metabolism governs cancer immune surveillance
OncoImmunology, 2017 The metabolic reprogramming that drives immunity engages the mevalonate pathway for cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this metabolic route is reflected by the fact that too low activity impairs ...
Georg Gruenbacher, Martin Thurnher
doaj +1 more source