Results 101 to 110 of about 30,985 (250)

Mevalonate kinase variants

, 2021
This dataset describes the effects of several mutations to human mevalonate kinase. The dataset is designed to be used with the Aquaria molecular graphics system (e.g., https://aquaria.app/Mouse/MVK?zenodo.3632187.V377I or https://aquaria.app/Mouse/MVK ...
Sean O'Donoghue, Mike Rogers
core   +1 more source

Silencing of juvenile hormone‐related genes through RNA interference leads to molt failure and high mortality in the spongy moth

Insect Science, EarlyView.
The feasibility of using RNA interference to control the globally important quarantine pest, the spongy moth. Targeting genes related to JHs play an important role in the growth and development of insects. First, the open reading frames (ORFs) of Ldjhamt and Ldjheh were identified and characterized, and the target genes were cloned and double‐stranded ...
Wenzhuai Ji, Qing Xie, Xiaoxiao Chang, Juan Shi   +3 more
wiley   +1 more source

Dynamics of Monoterpene Formation in Spike Lavender Plants

Metabolites, 2017
The metabolic cross-talk between the mevalonate (MVA) and the methylerythritol phosphate (MEP) pathways was analyzed in spike lavender (Lavandula latifolia Med) on the basis of 13CO2-labelling experiments using wildtype and transgenic plants ...
Isabel Mendoza-Poudereux, Erika Kutzner, Claudia Huber, Juan Segura, Isabel Arrillaga, Wolfgang Eisenreich   +5 more
doaj   +1 more source

25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway

, 2017
Mevalonate pathway deregulation has been observed in several diseases, including Mevalonate kinase deficiency (MKD). MKD is a hereditary auto-inflammatory disorder, due to mutations at mevalonate kinase gene (MVK), encoding mevalonate kinase (MK ...
Sergio Crovella, Rossella Gratton, Luca Braga, Fulvio Celsi, Tricarico, Paola Maura, Paola Maura Tricarico, GRATTON, ROSSELLA, Braga, Luca, Crovella, Sergio, Celsi, Fulvio   +9 more
core   +1 more source

LsFAMeT and LsJHAMT coordinate JH biosynthesis to regulate fecundity in Laodelphax striatellus

Insect Science, EarlyView.
The small brown planthopper (SBPH), Laodelphax striatellus, can trigger large‐scale outbreaks when encountering suitable habitats during migration due to their strong reproductive ability. This study investigated the role of juvenile hormone (JH) in regulating SBPH reproduction.
Yan Guo, Bing‐Bing Shi, Xue‐Qi Zhang, Qiong Yang   +3 more
wiley   +1 more source

Statins regulate kinase signaling by causing changes in phosphorylation, rather than through changes in gene expression or direct inhibition: evidence in colorectal cancer

Frontiers in Pharmacology
IntroductionStatins, widely used for hypercholesterolemia, have shown anticancer properties including induction of apoptosis and ferroptosis, modulation of autophagy, and reprogramming of the tumor microenvironment, making them potential candidates for ...
Francisco Alejandro Lagunas-Rangel, Francisco Alejandro Lagunas-Rangel, Jörgen Jonsson, Ludmila Jackevica, Robert Fredriksson, Maija Dambrova, Maija Dambrova, Helgi B. Schiöth, Helgi B. Schiöth   +8 more
doaj   +1 more source

Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds.

, 1979
1. Mevalonate pyrophosphate decarboxylase of rat liver is inhibited by various phenyl and phenolic acids. 2. Some of the phenyl and phenolic acids also inhibited mevalonate phosphate kinase. 3.
Ramasarma, T, Bhat, Shama C
core  

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase

FEBS Open Bio
Mevalonate kinase is a key regulator of the mevalonate pathway, subject to feedback inhibition by the downstream metabolite farnesyl pyrophosphate. In this study, we validated the hypothesis that monophosphonate compounds mimicking farnesyl pyrophosphate
Saman Salari, Hiu‐Fung Lee, Youla S. Tsantrizos, Jaeok Park   +3 more
doaj   +1 more source

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing[S]

Journal of Lipid Research, 2019
Sterol-regulated HMG-CoA reductase (HMGCR) degradation and SREBP-2 cleavage are two major feedback regulatory mechanisms governing cholesterol biosynthesis.
Liang Chen, Mei-Yan Ma, Ming Sun, Lu-Yi Jiang, Xue-Tong Zhao, Xian-Xiu Fang, Sin Man Lam, Guang-Hou Shui, Jie Luo, Xiong-Jie Shi, Bao-Liang Song   +10 more
doaj   +1 more source