Results 91 to 100 of about 30,985 (250)
Mapping Causal Biology: Mendelian Randomization in the Era of Big Data
Med Research, EarlyView.Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen +10 more
wiley +1 more source
Frontiers in Neuroscience, 2019 Farnesol, the sesquiterpenoid precursor of insect juvenile hormones (JH) that itself has JH activity, existed already long before animals and their hormones came into being.
Arnold De Loof, Liliane Schoofs
doaj +1 more source
Prostate Cancer and the Mevalonate Pathway
International Journal of Molecular SciencesAntineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to the emergence of resistance mechanisms that the tumor ...
Patricia Guerrero-Ochoa +7 more
openaire +3 more sources
Mevalonate kinase deficiency: current perspectives
, 2016 Leslie A Favier, Grant S Schulert Division of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA Abstract: Mevalonate kinase deficiency (MKD) is a recessively inherited autoinflammatory disorder with a spectrum of
Favier LA, Schulert GS
core
The Journal of Pathology, EarlyView.Abstract The progression of colorectal cancer (CRC) is critically regulated by cancer‐associated fibroblasts (CAFs) within the tumor microenvironment (TME), yet the specific molecular mechanisms by which CAFs influence CRC remain unclear. This study reveals the mechanism by which CAFs promote CRC malignant progression and immune suppression through ...
Huachi Li +6 more
wiley +1 more source
The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins
Frontiers in Pharmacology, 2019 The mevalonate pathway provides sterols for membrane structure and nonsterol intermediates for the post-translational modification and membrane anchorage of growth-related proteins, including the Ras, Rac, and Rho GTPase family.
Huanbiao Mo +5 more
doaj +1 more source
Comparison of LmMK and MmMK mevalonate-binding sites.
, 2018 (A) Structure of LmMK (grey) with mevalonate bound (green sticks). (B) Structure of chain A of MmMK (green) with mevalonate bound (green sticks). (C) Structure of MmMK (orange) with 5-phosphomevalonate bound (green sticks).
Bradley R. Miller (6058193) +1 more
core +1 more source
Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease
VIEW, EarlyView.This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin +5 more
wiley +1 more source
Metabolomics Analysis of the Toxic Effects of the Production of Lycopene and Its Precursors
Frontiers in Microbiology, 2018 Using cells as microbial factories enables highly specific production of chemicals with many advantages over chemical syntheses. A number of exciting new applications of this approach are in the area of precision metabolic engineering, which focuses on ...
April M. Miguez +2 more
doaj +1 more source
Magnetothermal‐responsive drug release bone cement based on EGFR‐mutated lung cancer bone metastases
VIEW, EarlyView.A novel magnetothermal‐responsive bone cement was developed by integrating PMMA/CPC/Osimertinib matrix with Fe3O4@SiO2@Zol nanomaterials. This dual‐drug system achieves controlled release, combining excellent mechanical properties with potent anti‐tumor activity and bone regulation for treating EGFR‐mutated LC‐BoM.
Kandi Xu +15 more
wiley +1 more source