Results 81 to 90 of about 24,078 (213)
Plant Biology, EarlyView.Herbicide residues in soil disrupt plant–insect signalling, reducing the effectiveness of biological pest control. Abstract Plants under herbivore attack emit distinct blends of herbivore‐induced plant volatiles (HIPVs) which serve as signalling cues for predatory insects.
B. Fuchs, J. D. Blande, V. Weijola
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Chemistry of mevalonic acid [PDF]
Biochemical Journal, 1969 J W, Cornforth, R H, Cornforth
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International Journal of Cancer, Volume 159, Issue 7, Page 1669-1685, 1 October 2026.Bisphosphonates are widely used to treat osteoporosis and to manage bone metastases in patients with breast cancer. Nitrogen‐based bisphosphonates may also broadly reduce cancer risk, but evidence remains inconsistent. This large population‐based data linkage study in women aged > 50 years found that, compared to no use of osteoporosis medicines ...
Karen M. Tuesley +7 more
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Production of Mevalonate from Glycerol by Escherichia coli Citrate Synthase Variants
FermentationMevalonate is a biochemical precursor to a wide range of isoprenoids. Because the mevalonate pathway uses three moles of acetyl–CoA, native pathways which metabolize acetyl–CoA, including citrate synthase, strongly compete with mevalonate synthesis.
Caroline E. Hartner, Mark A. Eiteman
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Mevalonate metabolism governs cancer immune surveillance
OncoImmunology, 2017 The metabolic reprogramming that drives immunity engages the mevalonate pathway for cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this metabolic route is reflected by the fact that too low activity impairs ...
Georg Gruenbacher, Martin Thurnher
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Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 3, September 2026.Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
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ACR Open Rheumatology, Volume 8, Issue 8, August 2026.The rapid integration of immune checkpoint inhibitors (ICIs) into standard oncology protocols has birthed a new frontier in clinical rheumatology: immune‐related adverse events (irAEs). By disrupting the programmed cell death‐1 (PD‐1)/PD‐L1 and cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) axes to restore antitumor T cell activity, these ...
Xizi Hu +3 more
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THE BIOSYNTHESIS OF MEVALONIC ACID [PDF]
Proceedings of the National Academy of Sciences, 1959 J J, Ferguson, I F, Durr, H, Rudney
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Cancer Medicine, Volume 15, Issue 8, August 2026.ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal +4 more
wiley +1 more source
Microbial model of Halobacterium salinarum for screening inhibitors of sterol biosynthesis
Антибиотики и Химиотерапия, 2020 A highly effective and simple microbial test system for screening inhibitors of sterol biosynthesis (ISB) is described. The system is based on cultivation of the bacterial strain Halobacterium salinarum (former Halobacterium halobium), that possesses ...
A. S. Trenin
doaj