Results 1 to 10 of about 5,468 (165)
Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways [PDF]
Frontiers in Plant Science, 2022 It is critical to develop plant isoprenoid production when dealing with human-demanded industries such as flavoring, aroma, pigment, pharmaceuticals, and biomass used for biofuels.
Ali Movahedi +11 more
doaj +2 more sources
Mevalonic acid exerts procoagulant effect by potentiating factor Xa [PDF]
Natural Products and BioprospectingThrombosis pathogenesis is closely linked to dysregulated lipid metabolism and inflammatory processes. However, the direct regulatory role of mevalonate pathway within the coagulation cascade is still not well understood.
Liyuan Niu +12 more
doaj +2 more sources
Diagnostic value of urinary mevalonic acid excretion in mevalonate kinase deficiency (MKD) [PDF]
Pediatr Rheumatol Online J, 2014 Mevalonate kinase deficiency (MKD) is a rare hereditary autoinflammatory syndrome, characterized by recurrent fever episodes with gastrointestinal complaints, rash and arthralgia. The deficient mevalonate kinase activity leads to elevated mevalonic acid, which is excreted in the urine.
Jeyaratnam J +4 more
europepmc +3 more sources
An ultrasensitive enzymatic method for measuring mevalonic acid in serum [PDF]
Journal of Lipid Research, 2012 We have developed a simple, precise, and ultrasensitive enzymatic method for measuring serum mevalonic acid (MVA) concentration, which is thought to be a good indicator of the in vivo cholesterol biosynthesis rate.
Takeshi Matsuoka +3 more
doaj +2 more sources
Case Report: Early-onset mevalonic aciduria in neonates with inflammatory marker elevated [PDF]
Frontiers in ImmunologyPurposeThe aim of this study was to present a case of early-onset mevalonic aciduria (MA) in a neonate and summarize the relevant phenotypic and genotypic spectra of MA.Methods and resultsWe describe a neonate who presented with elevated inflammatory ...
Shanshan Xue +7 more
doaj +2 more sources
A Distinct Phenotype of Mevalonic Acidemia with Absence of Pathogenic Mutations of Mevalonate Kinase Gene [PDF]
مجلة جامعة النجاح للأبحاث العلوم الطبيعية, 2016 Mevalonic aciduria is an autosomal recessive disorder caused by deficiency of mevalonate kinase and characterized by recurrent febrile crisis, ophthalmic and neurological manifestations.
Imad Dweikat, Nadera Damsa, Enas Naser
doaj +1 more source
Bacterial Metabolism of Mevalonic Acid [PDF]
Journal of Bacteriology, 1967 Soluble cell-free extracts of actinomycete S4 grown on media containing mevalonate catalyze acetoacetate formation from mevalonate, mevaldate, and β-hydroxy-β-methylglutaryl-coenzyme A (CoA). Conversion of mevalonate to acetoacetate involves formation of free β-hydroxy-β-methylglutaryl-CoA, but not free mevaldate.
M A, Siddiqi, V W, Rodwell
openaire +2 more sources
Production of Mevalonic Acid by Fermentation [PDF]
Applied Microbiology, 1968 The purpose of this investigation was to select microorganisms that produce substantial quantities of mevalonic acid and to develop an economic fermentation process. To screen for mevalonic acid-producing microorganisms, it was necessary to improve the method for the quantitative determination of this acid.
G, Tamura, K, Ando, K, Kodama, K, Arima
openaire +2 more sources
Mevalonic Acid Kinase in Euglena gracilis [PDF]
Plant Physiology, 1967 The isolation and partial purification of mevalonic acid kinase from Euglena gracilis is described. The product of the reaction MVA-5-P has been characterized by paper chromatography. The apparent Km values for l-mevalonic acid, ATP, and Mg(2+) are 3 x 10(-5)m, 6 x 10(-3)m, and 9 x 10(-3)m, respectively.
C Z, Cooper, C R, Benedict
openaire +2 more sources
Mevalonate metabolism by renal tissue in vitro
Journal of Lipid Research, 1974 Previous studies from this laboratory have demonstrated that the kidneys rather than the liver play the major role in the in vivo metabolism of circulating mevalonic acid.
Philip Raskin, Marvin D. Siperstein
doaj +1 more source