Results 11 to 20 of about 5,468 (165)

Urinary excretion of mevalonic acid as an indicator of cholesterol synthesis

open access: yesJournal of Lipid Research, 1996
Urinary excretion of mevalonic acid was investigated as an indicator of cholesterol synthesis. In normolipemic volunteers, excretion of mevalonic acid averaged 3.51 +/- 0.59 (SD) micrograms/kg x day1; (n = 24) and was not different from patients with ...
B Lindenthal   +5 more
doaj   +1 more source

INFLUENCE OF MEVALONIC ACID AND LINALOOL ON LIMONENE ACCUMULATION IN CALLUS TISSUES OF CITRUS GRANDIS OSBECK

open access: yesBiotropia: The Southeast Asian Journal of Tropical Biology, 2011
Effect on callus growth was studied for Citrus grandis  cultured with feeding of exogenous mevalonic acid (MVA) at concentrations of 0.04, 0.08, 0.38, 0.77, 1.15 and 1.54 mM.
ZARINA ZAKARIA   +2 more
doaj   +1 more source

Inhibition of cholesterol biogenesis by arsenite: preparation of labeled lanosterol*

open access: yesJournal of Lipid Research, 1961
When mevalonic acid-2-C14 was incubated with rat liver homogenate with the usual cofactors plus 10−3 M arsenite, the formation of labeled cholesterol was inhibited and labeled lanosterol accumulated.
Mary L. Moller, T.T. Tchen
doaj   +1 more source

EFFECTS OF STATINS UPON ANTIGEN-SPECIFIC LYMPHOCYTE ACTIVATION IN PATIENTS WITH RHEUMATOID ARTHRITIS: AN IN VITRO STUDY

open access: yesМедицинская иммунология, 2014
. Collagen type II (Col II) is among the proposed candidate autoantigens initiaiting rheumatoid arthritis (RA). Statins have been shown to have anti-inflammatory and immunomodulating properties. Mechanisms of statin effects upon the autoantigen-induced T
I. V. Shirinsky, V. S. Shirinsky
doaj   +1 more source

Studies on a mevaldic acid reductase of rat liver*

open access: yesJournal of Lipid Research, 1962
A TPNH-specific mevaldic reductase of rat liver has been partially purified. This enzyme fraction catalyzes the reduction of both optical isomers of mevaldic acid to isomeric mevalonic acids.
Harold J. Knauss   +2 more
doaj   +1 more source

Autoinflammatory disease syndrome of hyperimmunoglobulinemia D

open access: yesМедицинский вестник Юга России, 2022
Objective: present a clinical case of a rare autoinflammatory disease. Materials and methods: an analysis of a clinical case of mevalonate kinase deficiency syndrome in an 8-year-old girl was carried out.
T. M. Somova
doaj   +1 more source

Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta

open access: yesJournal of Lipid Research, 1973
Homogenates and subcellular fractions of the intima–media of hog aorta have been prepared and examined for the presence of the enzymes catalyzing the conversion of acetyl CoA to squalene.
Linda L. Slakey   +3 more
doaj   +1 more source

Ribonuclease Inhibition of Mevalonic Acid Utilization.

open access: yesExperimental Biology and Medicine, 1958
SummaryUtilization of mevalonic acid as determined by incorporation of the 2-C14-labeled compound into non-saponifiable material or into cholesterol or by disappearance of microbiological activity attributable to mevalonic acid in rat liver homogenates was found to be abolished by a preliminary digestion with ribonuclease.
L D, WRIGHT, M, CLELAND, B N, DUTTA
openaire   +2 more sources

Radioautographic visualization of incorporation of lipid precursors into anthers of Muscari comosum (L.) Mili.

open access: yesActa Societatis Botanicorum Poloniae, 2015
Incorporation of the following lipid precursors: DL-mevalonic acid-2 3H, 3H palmitic acid and acetic acid-3H sodium salt, into the anther cells of Muscari comosum (L.) Mili. has been investigated.
Barbara Gabara
doaj   +1 more source

Urinary Metabolites of Mevalonic Acid: Evidence That Mevalonic Acid is not a Precursor of Isovalthine

open access: yesExperimental Biology and Medicine, 1961
SummarySynthetic isovalthine (S-(isopropyl-carboxymethyl)-cysteine) was added to urine from hypercholesterolemic patients that had received mevalonic acid-2-C14 intravenously. Isovalthine recovered from the urine was found to be devoid of radioactivity thus indicating that either (a) mevalonic acid is not a precursor of isovalthine, or (b) mevalonic ...
L D, WRIGHT, W P, HOLLANDER
openaire   +2 more sources

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