Results 21 to 30 of about 5,468 (165)

Biosynthesis of cholesterol in rabbit reticulocytes and its exchange with plasma

Journal of Lipid Research, 1970
When rabbit reticulocytes were incubated in normal blood plasma containing mevalonic acid-2-(14)C, radioactivity was incorporated into cholesterol, cholesteryl esters, and squalene in the cells.
H.A. Sloviter, V. Janic, T. Cirkovic
doaj   +1 more source

Chromatographic separation of allylic alcohols on silicic acid columns: Analysis of the nonsaponifiable lipids of an ascites tumor derived from a benzpyrene-induced sarcoma

Journal of Lipid Research, 1963
Chromatographic separations of dimethyl allyl alcohol, geraniol, nerol, nerolidol, and trans-trans-farnesol were achieved on silicic acid-Super Cel columns.
George J. Schroepfer, Jr., Irene Youhotsky Gore   +1 more
doaj   +1 more source

Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia

Journal of Lipid Research, 1997
Apheresis only partially controls raised low density lipoprotein cholesterol levels in patients with homozygous familial hypercholesterolemia, who usually respond poorly to lipid-lowering drugs.
A D Marais, R P Naoumova, J C Firth, C Penny, C K Neuwirth, G R Thompson   +5 more
doaj   +1 more source

Priming by Hexanoic acid induce activation of mevalonic and linolenic pathways and promotes the emission of plant volatiles.

Frontiers in Plant Science, 2016
Hexanoic acid is a short natural monocarboxylic acid present in some fruits and plants. Previous studies reported that soil drench application of this acid induces effective resistance in tomato plants against Botrytis cinerea and Pseudomonas syringae ...
Eugenio eLlorens, Gemma eCamañes, Leonor eLapeña, Pilar eGarcía-Agustín   +3 more
doaj   +1 more source

Isolated neurological presentations of mevalonate kinase deficiency

JIMD Reports, 2023
Mevalonate kinase (MK) deficiency is a rare autosomal recessive metabolic disorder caused by pathogenic variants in the MVK gene with a broad phenotypic spectrum including autoinflammation, developmental delay and ataxia. Typically, neurological symptoms
Eva M. M. Hoytema van Konijnenburg, Esmeralda Oussoren, Joost Frenkel, Peter M. van Hasselt   +3 more
doaj   +1 more source

Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved

Viruses, 2021
Statin derivatives can inhibit the replication of a range of viruses, including hepatitis C virus (HCV, Hepacivirus), dengue virus (Flavivirus), African swine fever virus (Asfarviridae) and poliovirus (Picornaviridae).
Fauziah Mohd Jaafar, Baptiste Monsion, Mourad Belhouchet, Peter P. C. Mertens, Houssam Attoui   +4 more
doaj   +1 more source

Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth

Journal of Lipid Research, 1984
In summary, there is now ample evidence that cell growth, as well as DNA replication, is closely linked to cholesterogenesis in a manner that has only recently been appreciated.
M D Siperstein
doaj   +1 more source

Effect of mevalonate analogues upon cholesterol biosynthesis

Journal of Lipid Research, 1961
Three analogues of mevalonic acid have been found to inhibit cholesterol biosynthesis in liver homogenates in the following order of efficacy: 3-methyl-3-hydroxy pentanoic acid > Δ2-3-methyl pentenoic acid > Δ3-3-methyl pentenoic acid.
Herbert Weiss, Elliott Schiffmann, Elwood Titus   +2 more
doaj   +1 more source

Geranylgeranoic acid, a bioactive and endogenous fatty acid in mammals: a review

Journal of Lipid Research, 2023
Geranylgeranoic acid (GGA) was first reported in 1983 as one of the mevalonic acid metabolites, but its biological significance was not studied for a long time.
Yoshihiro Shidoji
doaj   +1 more source

An interstrain difference in cholesterol synthesis in vitro in mice, dependent upon a difference in endogenous NADPH-generating capacity

Journal of Lipid Research, 1972
Earlier experiments have shown that significantly more endogenously generated NADPH is available for reduction of corticosterone in liver homogenates from C57BL/10 male mice than in those from the DBA/2 strain.
Felicia Gaskin, R.B. Clayton
doaj   +1 more source