MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion [PDF]
Nature, 2017 Mitochondria are double-membraned organelles with variable shapes influenced by metabolic conditions, developmental stage, and environmental stimuli. Their dynamic morphology is a result of regulated and balanced fusion and fission processes.
Yu-Lu Cao, Yang Chen, Yu-Jie Li
exaly +8 more sources
Chronic stress-induced downregulation of MFN1 contributes to fatty liver in chickens [PDF]
Frontiers in Veterinary ScienceBackgroundChronic stress is a major contributor to Fatty Liver Syndrome (FLS) in fast-growing broilers, leading to physiological dysfunctions that compromise growth and immune response.
Ke Zhang +10 more
doaj +6 more sources
Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy [PDF]
AutophagyMFN1 (mitofusin 1) and MFN2 are key players in mitochondrial fusion, endoplasmic reticulum (ER)-mitochondria juxtaposition, and macroautophagy/autophagy. However, the mechanisms by which these proteins participate in these processes are poorly understood.
Isabel Gordaliza‐Alaguero +13 more
exaly +5 more sources
Loss of Mfn1 but not Mfn2 enhances adipogenesis.
PLoS ONE, 2022 ObjectiveA biallelic missense mutation in mitofusin 2 (MFN2) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles in adipocyte differentiation, growth and/or ...
Jake P Mann +15 more
doaj +4 more sources
Dynamic interaction of REEP5–MFN1/2 enables mitochondrial hitchhiking on tubular ER [PDF]
Journal of Cell BiologyChen et al. delineate a novel mode of mitochondrial migration by “hitchhiking” on ER via the protein tether pair between mitofusins (MFNs) and REEP5.
Shue Chen +8 more
semanticscholar +4 more sources
The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes
Communications Biology, 2022 The MFN1 and MFN2 mitofusin proteins localize to the outer mitochondrial membrane, where they may help functionally tether mitochondria to peroxisomes.
Yinbo Huo +4 more
doaj +4 more sources
MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice [PDF]
International Journal of Molecular Sciences, 2021 MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development.
Yuan Wang
exaly +4 more sources
Senolysis by GLS1 Inhibition Ameliorates Kidney Aging by Inducing Excessive mPTP Opening Through MFN1 [PDF]
The Journals of Gerontology, Series A: Biological Sciences and Medical SciencesCellular senescence is a pivotal contributor to aging and age-related diseases. The targeted elimination of senescent cells, known as senolysis, has emerged as a promising therapeutic strategy for mitigating these conditions.
Yuting Chen +7 more
semanticscholar +4 more sources
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development [PDF]
Journal of Cell Biology, 2003 Mitochondrial morphology is determined by a dynamic equilibrium between organelle fusion and fission, but the significance of these processes in vertebrates is unknown.
Andrew J Ewald +2 more
exaly +5 more sources
Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations [PDF]
The Journal of Cell Biology, 2007 Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration.
Chan, David C., Detmer, Scott A.
core +7 more sources