Saudi Pharmaceutical JournalThe mitochondria are responsible for the production of cellular ATP, the regulation of cytosolic calcium levels, and the organization of numerous apoptotic proteins through the release of cofactors necessary for the activation of caspases.
Adel Alghamdi
exaly +4 more sources
MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming [PDF]
British Journal of Cancer, 2019 Mitochondrial dynamics plays an important role in tumour progression. However, how these dynamics integrate tumour metabolism in hepatocellular carcinoma (HCC) metastasis is still unclear.
Ze Zhang, Ying Zhu, Xuan Wang
exaly +4 more sources
MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival [PDF]
Cell Death and Disease, 2014 AbstractMitochondrial dynamics and quality control have a central role in the maintenance of cellular integrity. Mitochondrial ubiquitin ligase membrane-associated RING-CH (MARCH5) regulates mitochondrial dynamics. Here, we show that mitochondrial adaptation to stress is driven by MARCH5-dependent quality control on acetylated Mfn1. Under mitochondrial
Hyeseong Cho
exaly +5 more sources
Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2
Molecular Biology of the Cell, 2019 Mitochondrial structure can be maintained at steady state or modified in response to changes in cellular physiology. This is achieved by the coordinated regulation of dynamic properties including mitochondrial fusion, division and transport.
Stephanie R. Sloat +3 more
semanticscholar +5 more sources
Journal of Hepatocellular Carcinoma, 2022 Objective Protodioscin (PD), a steroidal saponin, has a diverse pharmacological activity including neuroprotection, male fertility improvement, and cytotoxicity against various cancers cell lines of different origins.
Chen‐Lin Yu +6 more
openalex +3 more sources
Placenta, 2022 INTRODUCTION Controlling inflammation and apoptosis in trophoblasts is critical for treating gestational diabetes mellitus (GDM). Baicalein (Bai) exhibits anti-inflammatory and miRNA-related effects; however, its roles and mechanisms in GDM remain ...
Jie Li +5 more
openalex +2 more sources
MicroRNA-17-5p acts as a biomarker and regulates mitochondrial dynamics in trophoblasts and endothelial cells by targeting the mitofusins Mfn1/Mfn2 in gestational diabetes mellitus [PDF]
Archives of Medical Science, 2022 Gestational diabetes mellitus (GDM) is a metabolic disease that endangers pregnant women and their offspring. Insights into biomarkers and GDM pathogenesis are crucial.
Jie Li +4 more
openalex +2 more sources
Redox Biology, 2021 Rationale Myocardial infarction (MI) is a leading cause of cardiovascular mortality globally. The improvement of microvascular function is critical for cardiac repair after MI.
Yuqiong Chen, Dalin Jia
exaly +2 more sources
Mitofusin 1 in mitochondrial quality control and anti-inflammatory responses in nucleus pulposus cells during disc degeneration [PDF]
Scientific ReportsMitochondrial dysfunction drives intervertebral disc degeneration, and mitochondrial dynamics are regulated by mitofusins (MFNs). In this study, we evaluated the roles of MFN1 and MFN2 in mitochondrial quality control and their responses to inflammation ...
Jae Won Shin +7 more
doaj +2 more sources
The Effect of Eight Weeks of Aerobic Training Combined With Resveratrol on MFn1 and MFn2 Expression in Cardiac Myocytes in a Non-alcoholic Fatty Liver Animal Model [PDF]
Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2020 Objective: Nonalcoholic fatty liver disease is the most common chronic liver disorder. The present study aimed to examine the effect of aerobic training along with Resveratrol on the cardiac expression of Mfn1 and Mfn2 in nonalcoholic fatty liver disease
Hasan Delroz +3 more
doaj +2 more sources