Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization. [PDF]
, 2019 Glaucoma is characterized by a progressive optic nerve degeneration and retinal ganglion cell loss, but the underlying biological basis for the accompanying neurodegeneration is not known.
Ahn, Sangphil +6 more
core +4 more sources
Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria. [PDF]
Molecular Biology of the Cell, 2017 SCL25A46 is a mitochondrial carrier protein that surprisingly localizes to the outer membrane and is distantly related to Ugo1. Here we show that a subset of SLC25A46 interacts with mitochondrial dynamics components and the MICOS complex.
Claypool, Steven M +6 more
core +2 more sources
Correction: Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction [PDF]
Cell Death & Disease, 2021 A R Hall +8 more
semanticscholar +4 more sources
MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation [PDF]
Stem Cell Reports, 2020 Summary Although mitochondrial morphology is well-known for its role in cellular homeostasis, there is surprisingly little knowledge on whether mitochondrial remodeling is required for postnatal germ cell development.
Wei Chen +11 more
semanticscholar +3 more sources
Baicalin inhibits infectious bronchitis virus replication via MAVS-dependent interferon-β upregulation and mitochondrial function preservation [PDF]
Scientific ReportsThe inhibitory effect of baicalin on infectious bronchitis virus (IBV) replication is closely related to expression of the mitochondrial antiviral signaling protein (MAVS) in chicken embryonic kidney (CEK) cells.
Jiongjie He +3 more
doaj +2 more sources
Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis [PDF]
Cell Death and DiseaseCartilage degradation is considered a hallmark of end-stage osteoarthritis (OA), characterized by significant alterations in the extracellular matrix (ECM).
Bo Liu +6 more
doaj +2 more sources
Biomolecules, 2020 Mitochondria are double-membrane organelles that continuously undergo fission and fusion. Outer mitochondrial membrane fusion is mediated by the membrane proteins mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2), carrying a GTP hydrolyzing domain (GTPase) and ...
Andrés Tolosa-Díaz +3 more
doaj +2 more sources
Theranostics, 2020 Rationale: Malignant ascites caused by cancer cells results in poor prognosis and short average survival time. No effective treatment is currently available for malignant ascites.
Hui-juan Liu +16 more
semanticscholar +3 more sources
Salivary mitofusin levels in periodontal disease: a cross-sectional case-control study [PDF]
BMC Oral HealthBackground Mitofusin (Mfn) is a mitochondrial fusion protein. It has two isoforms (Mfn1 and 2) and is critical in intracellular energy production, calcium transfer, and phospholipid metabolism.
Ömer F. Okumuş +2 more
doaj +2 more sources
miR-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute lung injury by directly targeting MFN1 and MFN2 [PDF]
Acta Biochimica et Biophysica Sinica, 2020 Supplemental oxygen is commonly used to treat severe respiratory failure, while prolonged exposure to hyperoxia can induce acute lung injury characterized by the accumulation of reactive oxygen species (ROS) and pulmonary inflammation.
Genhua Mu +4 more
openalex +2 more sources