Heptad repeat regions of coiled-coil domains of Mfn1 are crucial for Mfn1 mediated mitochondrial fusion [PDF]
, 2018 Mitofusin mediate fusion of outer mitochondrial membranes (OMM). Recent studies have explained the role of GTPase domain for Mfn1 dimerization and outer mitochondrial membrane (OMM) fusion. Coiled-coiled domains [namely, coiled-coil/Middle domains (CC1MD) and coiled-coil-2 GTPase effector domain (CC2/GED)] form helical bundles that mediate open-to ...
Sansrity Sinha, Gopala Krishna Aradhyam
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MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1. [PDF]
Immunol ResWu X, Liu L, Zhao R, Chen W.
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The immunoproteasome subunit β2i ameliorates myocardial ischemia/reperfusion injury by regulating Parkin-Mfn1/2-mediated mitochondrial fusion [PDF]
Cellular and Molecular Life Sciences, 2023 Hui-Xiang Su +5 more
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International Journal of Experimental Pathology, 2019 The pathogenesis of cerebral ischaemia reperfusion injury (IRI) has not been fully described. Accordingly, there is little effective drug available for the treatment of cerebral IRI.
Yunjun Li
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Journal of Ardabil University of Medical Sciences, 2021 Background & objectives: Dynamic disorders of mitochondria cause the pathogenesis of many diseases, such as type 2 diabetes. Therefore, the aim of this study was to investigate the interactive effect of aerobic exercises and atorvastatin consumption on ...
Maryam Zolfali Pourfar +2 more
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Study on the inhibition of Mfn1 by plant-derived miR5338 mediating the treatment of BPH with rape bee pollen [PDF]
BMC Complementary and Alternative Medicine, 2018 Background Recent studies have found that plant derived microRNA can cross-kingdom regulate the expression of genes in humans and other mammals, thereby resisting diseases.
Xuan Chen +6 more
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Effect of Hydroxyapatite Nanoparticles on the Ultrastructure, Developmental Competence, and Expression of <i>ZP3</i>, <i>MFN1</i>, and <i>NPM2</i> in Vitrified Bovine GV Oocytes. [PDF]
Biology (Basel)Li XX +13 more
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Role of GTPase-Dependent Mitochondrial Dynamins in Heart Diseases
Frontiers in Cardiovascular Medicine, 2021 Heart function maintenance requires a large amount of energy, which is supplied by the mitochondria. In addition to providing energy to cardiomyocytes, mitochondria also play an important role in maintaining cell function and homeostasis.
Jiangen Liu +3 more
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Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity
Frontiers in Bioscience-Landmark, 2022 Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China.
Jinling Wang +6 more
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Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy
Scientific Reports, 2021 Prognosis of severe heart failure remains poor. Urgent new therapies are required. Some heart failure patients do not respond to established multidisciplinary treatment and are classified as “non-responders”.
Yung Ting Hsiao +14 more
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