Chlorpyrifos inhibits neural induction via Mfn1-mediated mitochondrial dysfunction in human induced pluripotent stem cells [PDF]
Scientific Reports, 2017 AbstractOrganophosphates, such as chlorpyrifos (CPF), are widely used as insecticides in agriculture. CPF is known to induce cytotoxicity, including neurodevelopmental toxicity. However, the molecular mechanisms of CPF toxicity at early fetal stage have not been fully elucidated.
Shigeru Yamada +4 more
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Emerging functions of mammalian mitochondrial fusion and fission [PDF]
, 2005 Mitochondria provide a myriad of services to the cell, including energy production, calcium buffering and regulation of apoptosis. How these diverse functions are coordinated among the hundreds of mitochondria in a given cell is largely unknown, but is ...
Chan, David C., Chen, Hsiuchen
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Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking
Molecular & Cellular Oncology, 2018 Imaging of fatty acid (FA) trafficking revealed that FAs stored in lipid droplets were delivered to mitochondria when the cells were starved. This delivery required cytoplasmic lipases and mitochondrial fusion activity, whereas lipid droplets were ...
Sarah Cohen +2 more
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Nature Communications, 2022 Sidarala et al. examine the importance of the mitochondrial structural proteins, Mitofusins 1 and 2 (Mfn1/2), in diabetes. They find that Mfn1/2 control blood glucose by preserving mitochondrial DNA content, rather than mitochondrial structure.
Vaibhav Sidarala +7 more
doaj +1 more source
OPA1 supports mitochondrial dynamics and immune evasion to CD8+ T cell in lung adenocarcinoma [PDF]
PeerJ, 2022 Background Mitochondrial fusion and fission were identified to play key roles during multiple biology process. Thus, we aim to investigate the roles of OPA1 in mitochondria fusion and immune evasion of non-small cell lung cancer cells.
Ying Wang +8 more
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Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission [PDF]
, 2015 Defects of mitochondrial dynamics are emerging causes of neurological disease. In two children presenting with severe neurological deterioration following viral infection we identified a novel homozygous STAT2 mutation, c.1836C4A (p.Cys612Ter), using ...
Anderson, G +14 more
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Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model [PDF]
, 2019 Mitofusin-2 (MFN2) is a mitochondrial outer-membrane protein that plays a pivotal role in mitochondrial dynamics in most tissues, yet mutations in MFN2, which cause Charcot-Marie-Tooth disease type 2A (CMT2A), primarily affect the nervous system.
A.K.M.G. Muhammad +23 more
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تاثیر هشت هفته برنامه آمادهسازی فوتبال و مصرف مکمل بتاولگاریس بر محتوای پروتئینهای OPA1 و MFN1 بازیکنان فوتبال [PDF]
مطالعات کاربردی علوم زیستی در ورزش, 2023 زمینه و هدف: از آنجا که خستگی جسمی ناشی از انجام فعالیت ورزشی طاقت فرسا، بر ساختار و عملکرد سیستم ایمنی تاثیر منفی می گذارد؛ اتخاذ تدابیر تغذیه ای برای تعویق خستگی و ممانعت از افت عملکرد سیستم ایمنی، پیشنهاد می شود.
محمدمهدی منشی +3 more
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Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis [PDF]
, 2004 A dynamic balance of organelle fusion and fission regulates mitochondrial morphology. During apoptosis this balance is altered, leading to an extensive fragmentation of the mitochondria.
Arnoult, Damien +5 more
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Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion [PDF]
, 2006 Mitofusins are conserved GTPases essential for the fusion of mitochondria. These mitochondrial outer membrane proteins contain a GTPase domain and two or three regions with hydrophobic heptad repeats, but little is known about how these domains interact ...
Chan, David C., Griffin, Erik E.
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