Results 201 to 210 of about 428,092 (271)

A Dual‐Layer Hydrogel Barrier Integrating Bio‐Adhesive and Anti‐Adhesive Properties Prevents Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
A new dual‐layer hydrogel barrier for preventing postoperative abdominal adhesions is developed. The inner layer, consisting of polyethyleneimine (PEI) and thioctic acid (TA), enhanced adhesion to moist tissues. The outer layer combines zwitterionic, thermoresponsive hyaluronic acid with anti‐inflammatory epigallocatechin gallate (EGCG) and forms a ...
Mena Asha Krishnan, Olawale A. Alimi, Mitchell Kuss, Tiffany N Razabdouski, Erika A Eksioglu, Bin Duan, Bo Liu   +6 more
wiley   +1 more source

FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice. [PDF]

Nat Commun
Xia JB, Liu K, Lin XL, Li HJ, Lin JH, Li L, Liang CQ, Cao Y, Wen N, Liao ZF, Zhao H, Park KS, Song GH, Ye ZB, Cai DQ, Ju ZY, Qi XF.   +16 more
europepmc   +1 more source

Nanohybrid Hydrogel with Dual Functions: Controlled Low‐Temperature Photothermal Antibacterial Activity and Promoted Regeneration for Treating MRSA‐Infected Bone Defects

Advanced Healthcare Materials, EarlyView.
An injectable polydopamine‐based nanohybrid hydrogel integrates controlled low‐temperature photothermal therapy with potent antibacterial efficacy against MRSA while promoting robust bone regeneration. The hydrogel's composite design triggers HSP70 expression, facilitating osteogenesis and efficient bone formation.
Fang Yang, Zewen Shi, Yiwei Hu, Qian Pang, Tianyu Du, Baiyang Song, Jiaqi Zhong, Xiaodong Hu, Weilai Zhu, Junhong Chen, Lin Shi, Xianjun Chen, Qingjiang Pang, Yabin Zhu   +13 more
wiley   +1 more source

Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice. [PDF]

Cell Commun Signal
Liu DH, Li F, Yang RZ, Wu Z, Meng XY, Li SM, Li WX, Li JK, Wang DD, Wang RY, Li SA, Liu PP, Kang JS.   +12 more
europepmc   +1 more source

Tri‐Layered Bioactive Cutaneous Scaffold with Integrated Bioactive Metal Organic Frameworks to Promote Full‐Thickness Infected Diabetic Wound Healing: Multifaceted Therapeutic Strategies

Advanced Healthcare Materials, EarlyView.
The limitations of existing clinical treatments highlight the need for a more comprehensive strategy for addressing infected diabetic wounds. A tri‐layered scaffold is developed to deliver therapeutics loaded in CuBDC and ZIF‐8 MOFs that are tailored to the requirements of deep‐infected diabetic wounds.
Ayse Gunyakti Mujtaba, Ayşe Karakeçili, Berna Topuz, Barış Batur, Okan Onar, Mehmet Eray Elçiğir, Çağdaş Oto, Alireza Hanifehnezhad, Kaan Orhan   +8 more
wiley   +1 more source

Role of RGS17 in cisplatin-induced cochlear inflammation and ototoxicity via caspase-3 activation. [PDF]

Front Immunol
Al Aameri RFH, Alanisi EMA, Al Sallami D, Alberts I, Tischkau S, Rybak LP, Ramkumar V.   +6 more
europepmc   +1 more source

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Sustained release of cytokines from migrasomes. [PDF]

Extracell Vesicles Circ Nucl Acids
Zhen Y, Stenmark H.
europepmc   +1 more source

Tumor‐Targeted Exosome‐Based Heavy Atom‐Free Nanosensitizers With Long‐Lived Excited States for Safe and Effective Sono‐Photodynamic Therapy of Solid Tumors

Advanced Healthcare Materials, EarlyView.
Engineered exosome‐based heavy atom‐free nanosensitizers are developed for safe and targeted sono‐photodynamic therapy of solid tumors. The IR820‐TPE‐loaded, biotin‐conjugated exosomes (IR820‐TPE@B‐Exo) demonstrate significant promise for NIR fluorescence imaging‐guided sono‐photodynamic cancer therapy.
Van‐Nghia Nguyen, Thuy Giang Nguyen Cao, Hyunsun Jeong, Quan Truong Hoang, Binh T. T. Pham, Jieun Bang, Chang Woo Koh, Ji Hee Kang, Jeong Hyun Lee, Xiaofeng Wu, Won Jong Rhee, Young Tag Ko, K. M. K. Swamy, Sungnam Park, JaeHong Park, Min Suk Shim, Juyoung Yoon   +16 more
wiley   +1 more source

Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism. [PDF]

PLoS One
Tsuneki H, Maeda T, Takatsuki M, Sekine T, Masui S, Onishi K, Takeda R, Sugiyama M, Sakurai T, Yanagisawa M, Wada T, Sasaoka T.   +11 more
europepmc   +1 more source