Results 61 to 70 of about 1,004,074 (357)

Mechanism and Application of Baker–Venkataraman O→C Acyl Migration Reactions [PDF]

, 2014
This literature review focuses on the O→C acyl migration of aryl esters to yield the corresponding 1,3-dicarbonyl products—a reaction known as the Baker–Venkataraman rearrangement—and outlines their subsequent transformations.
Ameen, Dana, Snape, Timothy James
core   +1 more source

Green and selective alkylation of barbituric acid and 1-phenyl-tetrazole-5-thione with α,β-unsaturated systems using Fe3O4@SiO2-(CH2)3-PHtt-Cu (II) magnetic catalyst

Applied Catalysis O: Open
In this research, we immobilized the organic copper complex (1-phenyl-tetrazole-5-thione-Cu (II)) by (3-chloropropyltrimethoxysilane) on silica-coated magnetite (Fe3O4@SiO2). The structure of Fe3O4@SiO2-(CH2)3-PHtt-Cu(II) (FSTU) was confirmed using FT-IR,
Siamak Atabak, Gholamhassan Imanzadeh, Mohammadali Pourshahi, Zahra Soltanzadeh, Roghayyeh Asgharzadeh   +4 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Catalytic, enatioselective Michael addition reactions [PDF]

Arkivoc, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
S. C. Jha, N. N. Joshi
openaire   +1 more source

Dihydropyran Formation by a Two Step Process [PDF]

, 2010
The 2, 6-disubstitued dihydropyran is produced by a two step process, involving a Suzuki Miyaura Cross Coupling reaction followed by anintramolecular ring closing Michael Addition reaction.
Wright, James Zachary
core   +1 more source

Synthesis of b-substituted alanines via Michael addition of nucleophiles to dehydroalanine derivatives [PDF]

, 2000
Several b-substituted alanines are synthesised in high yields by a Michael addition of nucleophiles to N-acyl,N-tert-butyloxycarbonyl-dehydroalanine methyl ester, using mild reaction conditions and simple work-up procedures.
Ferreira, Paula M. T., Maia, Hernâni L. S., Monteiro, Luís S., Sacramento, Joana, Sebastião, Joana   +4 more
core   +1 more source

Diastereoselective synthesis of highly substituted cyclohexanones and tetrahydrochromene-4-ones via conjugate addition of curcumins to arylidenemalonates

Beilstein Journal of Organic Chemistry
A cascade inter–intramolecular double Michael strategy for the synthesis of highly functionalized cyclohexanones from curcumins and arylidenemalonates is reported. This strategy works in the presence of aqueous KOH using TBAB as a suitable phase transfer
Deepa Nair, Abhishek Tiwari, Banamali Laha, Irishi N. N. Namboothiri   +3 more
doaj   +1 more source

Acetic acid mediated Michael-addition/cyclization cascade sequence of cyclic diones and enones; A convenient, proficient, and eco-friendly access to the fused dihydropyrans

Journal of Saudi Chemical Society, 2023
An acetic acid-mediated Michael addition-cyclization cascade sequence of cyclic diones and enones is developed to afford fused dihydropyrans. A broad range of structurally diverse aliphatic, aromatic, and functionalized enones are successfully employed ...
Maira Hasnain Pasha, Humaira Yasmeen Gondal, Sami A. Alhussain, Mavra Jamshaid, Magdi E.A. Zaki   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Novel RNA catalysts for the Michael reaction [PDF]

Chemistry & Biology, 2001
In vitro selected ribozymes with nucleotide synthase, peptide and carbon-carbon bond forming activity provide insight into possible scenarios on how chemical transformations may have been catalyzed before protein enzymes had evolved. Metabolic pathways based on ribozymes may have existed at an early stage of evolution.We have isolated a novel ribozyme ...
Sengle, Gerhard, Eisenführ, Alexander, Arora, Paramjit S, Nowick, James S, Famulok, Michael   +4 more
openaire   +2 more sources