Results 71 to 80 of about 634,170 (178)

Red-shifting mutation of light-driven sodium-pump rhodopsin

Nature Communications, 2019
Microbial rhodopsins are photoreceptive and widely used in optogenetics for which they should preferable function with longer-wavelength light. Here, authors achieve a 40-nm red-shift in the absorption wavelength of a sodium-pump rhodopsin (KR2) by ...
Keiichi Inoue, María del Carmen Marín, Sahoko Tomida, Ryoko Nakamura, Yuta Nakajima, Massimo Olivucci, Hideki Kandori   +6 more
doaj   +1 more source

Na⁺ Binding and Transport: Insights from Light-Driven Na⁺-Pumping Rhodopsin

Molecules, 2023
Na+ plays a vital role in numerous physiological processes across humans and animals, necessitating a comprehensive understanding of Na+ transmembrane transport.
Qifan Yang, Deliang Chen
doaj   +1 more source

Scotty: lattice coincidences in the Protein Data Bank

Acta Crystallographica Section D, Volume 82, Issue 7, Page 824-835, July 2026.
Scotty supports crystallographic comparisons of lattice coincidences, the interpretation of oligomeric assemblies and paracrystallinity.The application Scotty, implemented within the Phasertng codebase, was used to perform a PDB‐wide analysis of lattice coincidences.
Airlie J. McCoy, Lawrence C. Andrews, Herbert J. Bernstein, Randy J. Read   +3 more
wiley   +1 more source

Gate-keeper of ion transport—a highly conserved helix-3 tryptophan in a channelrhodopsin chimera, C1C2/ChRWR

Biophysics and Physicobiology, 2020
Microbial rhodopsin is a large family of membrane proteins having seven transmembrane helices (TM1-7) with an all-trans retinal (ATR) chromophore that is covalently bound to Lys in the TM7. The Trp residue in the middle of TM3, which is homologous to W86
Yujiro Nagasaka, Shoko Hososhima, Naoko Kubo, Takashi Nagata, Hideki Kandori, Keiichi Inoue, Hiromu Yawo   +6 more
doaj   +1 more source

Microbial Metabolite‐Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Bitter taste receptors (T2Rs) play an important role in physiological and cellular responses. Bitter tasting chemicals and microbial metabolites can bind to T2R14, which enables interactions between T2R14 and specific intracellular domains of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel.
Tejas Gupte, Nisha Singh, Vikram Bhatia, Kavisha Arora, Shayan Amiri, Paul Fernyhough, Anjaparavanda P. Naren, Shyamala Dakshinamurti, Prashen Chelikani   +8 more
wiley   +1 more source

Nature’s toolkit for microbial rhodopsin ion pumps [PDF]

Proceedings of the National Academy of Sciences, 2014
Microbial rhodopsins function as light-driven (retinal-based) ion pumps, cation channels, or light sensors in various microorganisms [see Heberle et al.’s Retinal Proteins—You can teach an old dog new tricks (1)], are found in all three domains of life (2⇓–4), and were recently reported in viruses as well (5, 6).
Béjà, Oded, Lanyi, Janos K
openaire   +4 more sources

Editorial on Special Issue “The Advances and Applications of Optogenetics”

Applied Sciences, 2020
This Special Issue provides an update for the rapidly developing technology known as “optogenetics” that is the use of genetically encoded light-sensitive molecular elements (usually derived from lower organisms) to control or report various ...
Elena G. Govorunova, Oleg A. Sineshchekov   +1 more
doaj   +1 more source

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, Volume 106, Issue 8, Page 4521-4549, June 2026.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source

Photoisomerization detected in a fully wavelength‐tunable rhodopsin mimic system

Acta Crystallographica Section D, Volume 82, Issue 6, Page 664-671, June 2026.
The mechanism of retinal photoswitching is illuminated in a designed rhodopsin mimic. Two mechanisms, a conventional cis–trans isomerization and an unprecedented `photodehydration', are observed at atomic resolution in single crystals.We describe the photoisomerization of the retinylidene protonated Schiff base in human retinol‐binding protein II ...
Nona Ehyaei, Courtney Bingham, Katelyn Silva, Zahra Nossoni, Hadi Nayebi Gavgani, Meisam Nosrati, Joelle Eaves, Mustapha Akhdar, Chrysoula Vasileiou, Babak Borhan, James H. Geiger   +10 more
wiley   +1 more source

The evolutionary kaleidoscope of rhodopsins

, 2022
Rhodopsins are widely distributed across all domains of life where they perform a plethora of functions through conversion of electromagnetic radiation into physicochemical signals(Rozenberg et al., 2021).
Paul-Adrian Bulzu (8676138), Rohit Ghai (744045), Vinicius Kavagutti (6518306), Adrian-Ştefan Andrei (2606905)   +3 more
core   +1 more source