Mathematical model combined with microdosimetric kinetic model for tumor volume calculation in stereotactic body radiation therapy [PDF]
Scientific Reports, 2023 We proposed a new mathematical model that combines an ordinary differential equation (ODE) and microdosimetric kinetic model (MKM) to predict the tumor-cell lethal effect of Stereotactic body radiation therapy (SBRT) applied to non-small cell lung cancer
Hisashi Nakano +7 more
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Individual dosimetry system for targeted alpha therapy based on PHITS coupled with microdosimetric kinetic model [PDF]
EJNMMI Physics, 2021 Background An individual dosimetry system is essential for the evaluation of precise doses in nuclear medicine. The purpose of this study was to develop a system for calculating not only absorbed doses but also EQDX(α/β) from the PET-CT images of ...
Tatsuhiko Sato +6 more
doaj +5 more sources
Modelling Dose Effects from Space Irradiations: Combination of High-LET and Low-LET Radiations with a Modified Microdosimetric Kinetic Model [PDF]
Life, 2020 The Microdosimetric Kinetic Model (MKM) to predict the effects of ionizing radiation on cell colonies is studied and reformulated for the case of high-linear energy transfer (LET) radiations with a low dose.
Alejandro Bertolet, Alejandro Carabe
doaj +5 more sources
Biological dosimetric impact of dose-delivery time for hypoxic tumour with modified microdosimetric kinetic model [PDF]
Reports of Practical Oncology and Radiotherapy, 2023 An improved microdosimetric kinetic model (MKM) can address radiobiological effects with prolonged delivery times. However, these do not consider the effects of oxygen. The current study aimed to evaluate the biological dosimetric effects associated with the dose delivery time in hypoxic tumours with improved MKM for photon radiation therapy.Cell ...
Kawahara, Daisuke, Nagata, Yasushi
europepmc +3 more sources
RBE-weighted dose conversions for patients with recurrent nasopharyngeal carcinoma receiving carbon-ion radiotherapy from the local effect model to the microdosimetric kinetic model [PDF]
Radiation Oncology, 2020 Background We sought to establish a conversion curve to convert the RBE-weighted doses calculated by local effect model I (LEM) (LEM RBE-weighted doses) in patients with locally recurrent nasopharyngeal carcinoma (rNPC) to the RBE-weighted doses ...
Liwen Zhang +4 more
doaj +2 more sources
Effect of dose-delivery time for flattened and flattening filter-free photon beams based on microdosimetric kinetic model. [PDF]
PLoS ONE, 2018 The effect of dose-delivery time with flattening filter (FF) and flattening filter-free (FFF) photon beams based on microdosimetric kinetic model (MKM) was investigated in this study.
Hisashi Nakano +4 more
doaj +2 more sources
Revisiting fractionation in prostate carbon ion therapy: first comparative analysis of biologically effective dose using mMKM with diverse parameters [PDF]
Radiation OncologyBackground Carbon ion radiotherapy (CIRT) for prostate cancer has evolved from conventional regimens [66 Gy(RBE)/20 fractions (66G20), 63 Gy(RBE)/20 fractions (63G20)] toward hypofractionated schedules [57.6 Gy(RBE)/16 fractions (57.6G16), 51.6 Gy(RBE ...
Chi-Chuan Chiou +7 more
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Quantitative estimation of DNA damage by photon irradiation based on the microdosimetric-kinetic model. [PDF]
J Radiat Res, 2014 The microdosimetric-kinetic (MK) model is one of the models that can describe the fraction of cells surviving after exposure to ionizing radiation. In the MK model, there are specific parameters, k and yD, where k is an inherent parameter to represent the number of potentially lethal lesions (PLLs) and yD indicates the dose-mean lineal energy in keV/μm.
Matsuya Y +5 more
europepmc +5 more sources
Improved dose compensation model owing to short irradiation interruption time for hypoxic tumor using a microdosimetric kinetic model. [PDF]
Rep Pract Oncol RadiotherThe objective was to enhance the biological compensation factor related to irradiation interruption in a short time (short irradiation interruption) in hypoxic tumors using a refined microdosimetric kinetic model (MKM) for photon radiation therapy.The biological dose differences were calculated for CHO-K1 cells exposed to a photon beam, considering ...
Kawahara D.
europepmc +3 more sources
Generality Assessment of a Model Considering Heterogeneous Cancer Cells for Predicting Tumor Control Probability for Stereotactic Body Radiation Therapy Against Non-Small Cell Lung Cancer [PDF]
Advances in Radiation OncologyThe generality of a model for predicting tumor control probability from in vitro clonogenic survival considering of cancer stem-like cells, the so-called integrated microdosimetric-kinetic model, is presented by comparing the model to public data on ...
Ryo Saga, PhD +6 more
doaj +2 more sources