Results 111 to 120 of about 483 (145)
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Physics in Medicine & Biology, 2021
Abstract For hypo-fractionated multi-ion therapy (HFMIT), the stochastic microdosimetric kinetic (SMK) model had been developed to estimate the biological effectiveness of radiation beams with wide linear energy transfer (LET) and dose ranges.
Taku Inaniwa +4 more
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Abstract For hypo-fractionated multi-ion therapy (HFMIT), the stochastic microdosimetric kinetic (SMK) model had been developed to estimate the biological effectiveness of radiation beams with wide linear energy transfer (LET) and dose ranges.
Taku Inaniwa +4 more
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Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model
Physics in Medicine and Biology, 2010We describe a method to calculate the relative biological effectiveness in mixed radiation fields of therapeutic ion beams based on the modified microdosimetric kinetic model (modified MKM). In addition, we show the procedure for integrating the modified MKM into a treatment planning system for a scanned carbon beam.
Taku, Inaniwa +7 more
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Physica Medica, 2021
To implement RBE calculations in treatment planning systems based on the Microdosimetric Kinetic Model (MKM) upon analytical calculations of dose-mean lineal energy (yD). MKM relies on the patterns of energy deposition in sub-nuclear structures called domains, whose radii are cell-specific and need to be determined.The radius of a domain (rd) can be ...
A. Bertolet +2 more
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To implement RBE calculations in treatment planning systems based on the Microdosimetric Kinetic Model (MKM) upon analytical calculations of dose-mean lineal energy (yD). MKM relies on the patterns of energy deposition in sub-nuclear structures called domains, whose radii are cell-specific and need to be determined.The radius of a domain (rd) can be ...
A. Bertolet +2 more
openaire +2 more sources
Physica Medica, 2021
To develop and verify effective dose (DRBE) calculation in 4He ion beam therapy based on the modified microdosimetric kinetic model (mMKM) and evaluate the bio-sensitivity of mMKM-based plans to clinical parameters using a fast analytical dose engine.Mixed radiation field particle spectra (MRFS) databases have been generated with Monte-Carlo (MC ...
B. Kopp +9 more
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To develop and verify effective dose (DRBE) calculation in 4He ion beam therapy based on the modified microdosimetric kinetic model (mMKM) and evaluate the bio-sensitivity of mMKM-based plans to clinical parameters using a fast analytical dose engine.Mixed radiation field particle spectra (MRFS) databases have been generated with Monte-Carlo (MC ...
B. Kopp +9 more
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LET‐based approximation of the microdosimetric kinetic model for proton radiotherapy
Medical PhysicsAbstractBackgroundPhenomenological relative biological effectiveness (RBE) models for proton therapy, based on the dose‐averaged linear energy transfer (LET), have been developed to address the apparent RBE increase towards the end of the proton range.
Alessio, Parisi +3 more
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Radiation Research, 2018
An expression for the surviving fraction of a replicating population of cells exposed to permanently incorporated radionuclide is derived from the microdosimetric-kinetic model. It includes dependency on total implant dose, linear energy transfer (LET), decay rate of the radionuclide, the repair rate of potentially lethal lesions in DNA and the volume ...
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An expression for the surviving fraction of a replicating population of cells exposed to permanently incorporated radionuclide is derived from the microdosimetric-kinetic model. It includes dependency on total implant dose, linear energy transfer (LET), decay rate of the radionuclide, the repair rate of potentially lethal lesions in DNA and the volume ...
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Radiation Research, 2014
Relationships based on the microdosimetric-kinetic model are presented that calculate the average number of lethal lesions, and the associated cell survival, produced in mammalian cells by exposure to protracted continuous irradiation by temporary and permanent implantation of radioactive sources.
Roland B, Hawkins, Taku, Inaniwa
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Relationships based on the microdosimetric-kinetic model are presented that calculate the average number of lethal lesions, and the associated cell survival, produced in mammalian cells by exposure to protracted continuous irradiation by temporary and permanent implantation of radioactive sources.
Roland B, Hawkins, Taku, Inaniwa
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Physics in Medicine and Biology, 2017
Models able to predict relative biological effectiveness (RBE) values are necessary for an accurate determination of the biological effect with proton and 4He ion beams. This is particularly important when including RBE calculations in treatment planning studies comparing biologically optimized proton and 4He ion beam plans.
A, Mairani +8 more
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Models able to predict relative biological effectiveness (RBE) values are necessary for an accurate determination of the biological effect with proton and 4He ion beams. This is particularly important when including RBE calculations in treatment planning studies comparing biologically optimized proton and 4He ion beam plans.
A, Mairani +8 more
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Radiation Research, 2001
Hawkins, R. B. A Microdosimetric-Kinetic Model for the Sensitization of V79 Cells to Radiation by Incorporation of Bromodeoxyuridine. Radiat. Res. 155, 698-702 (2001). The sensitization of G(1)-phase V79 cells to killing by ionizing radiation through incorporation of bromodeoxyuridine (BrdU) in their DNA has been reported to occur exclusively through ...
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Hawkins, R. B. A Microdosimetric-Kinetic Model for the Sensitization of V79 Cells to Radiation by Incorporation of Bromodeoxyuridine. Radiat. Res. 155, 698-702 (2001). The sensitization of G(1)-phase V79 cells to killing by ionizing radiation through incorporation of bromodeoxyuridine (BrdU) in their DNA has been reported to occur exclusively through ...
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Radiation Protection Dosimetry
Abstract This study introduces the MKM_B model, an approach derived from the MKM model, designed to evaluate the biological effectiveness of Boron Neutron Capture Therapy (BNCT) in the face of challenges from varying microscopic boron distributions. The model introduces a boron compensation factor, allowing for the assessment of compound
Mingzhu Li +6 more
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Abstract This study introduces the MKM_B model, an approach derived from the MKM model, designed to evaluate the biological effectiveness of Boron Neutron Capture Therapy (BNCT) in the face of challenges from varying microscopic boron distributions. The model introduces a boron compensation factor, allowing for the assessment of compound
Mingzhu Li +6 more
openaire +2 more sources