Evaluation of relative biological effectiveness of 225Ac and its decay daughters with Monte Carlo track structure simulations [PDF]
EJNMMI PhysicsBackground 225Ac is a radionuclide that can be utilized in targeted alpha therapy (TAT). To accurately assess the absorbed dose and radiation effects in TAT, it is necessary to calculate the relative biological effectiveness (RBE).
Ziyi Hu +9 more
doaj +2 more sources
Variation of the relative biological effectiveness in the penumbra of ion therapy beams estimated using different microdosimetric approaches [PDF]
Physics and Imaging in Radiation OncologyBackground and Purpose: The effort to translate clinical findings across institutions employing different relative biological effectiveness (RBE) models of ion radiotherapy has rapidly grown in recent years.
Alessio Parisi +2 more
doaj +2 more sources
Validation of the relative biological effectiveness of active-energy scanning carbon-ion radiotherapy on a commercial treatment planning system with a microdosimetic kinetic model [PDF]
Radiation Oncology, 2023 Background The study objective was to validate the relative biological effectiveness (RBE) calculated by the modified microdosimetric kinetic model in RayStation (Ray-MKM) for active-energy scanning carbon-ion radiotherapy.
Weiwei Wang +3 more
doaj +2 more sources
The Estimated Difference in Biologically Effective Dose Between Two-Opposing-Fields-Per-Day and One-Alternating-Field-Per-Day Carbon Ion Radiation Therapy for Prostate Cancer [PDF]
Advances in Radiation OncologyPurpose: This study aims to determine whether two-opposing-fields-per-day (2-fields-per-day) carbon ion radiation therapy for prostate cancer provides a significant advantage in terms of biologically effective dose (BED) for normal tissue compared to the
Chi-Chuan Chiou, MD +7 more
doaj +2 more sources
Establishment of a practical methodology for evaluating equieffective dose of individual patients based on RT-PHITS [PDF]
EJNMMI PhysicsBackground The RadioTherapy package based on PHITS (RT-PHITS) is an individual dosimetry system applicable to both targeted radionuclide therapy (TRT) and external radiotherapy.
Tatsuhiko Sato +3 more
doaj +2 more sources
Mixed- and multi-relative biological effectiveness model simultaneous optimization in carbon ion radiotherapy: A proof-of-concept [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: In carbon ion radiotherapy (CIRT), different relative biological effectiveness (RBE) models have been used for calculating RBE-weighted dose (DRBE).
Aaron Paul Osburg +8 more
doaj +2 more sources
ComputationAmong existing radiobiological models, the MKM and its extensions (SMK and OSMK) have demonstrated strong predictive capabilities but remain computationally demanding.
Giuseppe Magro +5 more
doaj +2 more sources
A novel system for micron-scale analysis of energy deposition and response to low-dose radiation. [PDF]
Med PhysAbstract Background Micrometer‐scale evaluation of energy deposition is important for radiation protection and therapy as well as for advancing knowledge of responses to radiation in materials and biological systems. Due to the stochastic nature of radiation interactions, there is significant variation in energy deposition in micrometer‐sized targets ...
Pasricha P +11 more
europepmc +2 more sources
Measurement of microdosimetric spectra of high-LET particle beams using the ENCORE detector. [PDF]
Med PhysAbstract Background Heavy ion radiotherapy offers distinct advantages over conventional treatments due to its superior dose distribution and enhanced biological effectiveness. However, the microdosimetric characteristics of high linear energy transfer (LET) ions, particularly near the Bragg peak, remain poorly characterized.
Hartzell S +6 more
europepmc +2 more sources
Equivalent relative biological effectiveness for cell survival and micronuclei formation: insights from a biophysical approach. [PDF]
Med PhysAbstract Background Micronuclei (MN), which are chromosome fragments, are formed after exposure to ionizing radiation. Radiation‐induced MN is currently used as a quantitative indicator of the chromosomal aberrations detectable at a relatively early phase (e.g., within one cell‐cycle progression).
Matsuya Y, Saga R, Wang Y, Sato T.
europepmc +2 more sources