Results 21 to 30 of about 483 (145)

Carbon Ion Dose Constraints in the Head and Neck and Skull Base: Review of MedAustron Institutional Protocols [PDF]

International Journal of Particle Therapy, 2021
Background: Dose constraints are of paramount importance for the outcome of any radiotherapy treatment. In this article, we report dose-volume constraints as well as currently used fractionation schedules for carbon ion radiotherapy as applied in ...
Piero Fossati, MD, Ana Perpar, MD, Markus Stock, PhD, Petra Georg, MD, Antonio Carlino, PhD, Joanna Gora, PhD, Giovanna Martino, MSc, Eugen B. Hug, MD   +7 more
doaj   +1 more source

First theoretical determination of relative biological effectiveness of very high energy electrons

Scientific Reports, 2021
Very high energy electrons (VHEEs, E > 70 MeV) present promising clinical advantages over conventional beams due to their increased range, improved penumbra and relative insensitivity to tissue heterogeneities.
Rachel Delorme, Thongchai A. M. Masilela, Camille Etoh, François Smekens, Yolanda Prezado   +4 more
doaj   +1 more source

Predicting the Biological Effects of Human Salivary Gland Tumour Cells for Scanned ⁴He-, ¹²C-, ¹⁶O-, and ²⁰Ne-Ion Beams Using an SOI Microdosimeter

Applied Sciences, 2022
Experimental microdosimetry along with the microdosimetric kinetic (MK) model can be utilized to predict the biological effects of ions. To predict the relative biological effectiveness (RBE) of ions and the survival fraction (SF) of human salivary gland
Sung Hyun Lee, Kota Mizushima, Shunsuke Yonai, Shinnosuke Matsumoto, Hideyuki Mizuno, Taku Nakaji, Ryosuke Kohno, Yoshiyuki Iwata, Toshiyuki Shirai, Vladimir Pan, Angela Kok, Marco Povoli, Linh T. Tran, Anatoly B. Rosenfeld, Masao Suzuki, Taku Inaniwa   +15 more
doaj   +1 more source

A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy

Cells, 2020
Boron neutron capture therapy (BNCT) is a type of radiation therapy for eradicating tumor cells through a 10B(n,α)7Li reaction in the presence of 10B in cancer cells.
Yusuke Matsuya, Hisanori Fukunaga, Motoko Omura, Hiroyuki Date   +3 more
doaj   +1 more source

Across the stages: a multiscale extension of the generalized stochastic microdosimetric model (MS-GSM2) to include the ultra-high dose rate

Frontiers in Physics, 2023
Ultra-high dose rate (UHDR) irradiations with different types of radiation have shown a larger sparing of normal tissue and unchanged tumor control with respect to conventional delivery.
Marco Battestini, Marco Battestini, Marta Missiaggia, Andrea Attili, Francesco Tommasino, Francesco Tommasino, Chiara La Tessa, Francesco G. Cordoni, Francesco G. Cordoni, Emanuele Scifoni   +9 more
doaj   +1 more source

Sensitivity study of the microdosimetric kinetic model parameters for carbon ion radiotherapy [PDF]

Physics in Medicine & Biology, 2018
In carbon ion therapy treatment planning, the relative biological effectiveness (RBE) is accounted for by optimization of the RBE-weighted dose (biological dose). The RBE calculation methods currently applied clinically in carbon ion therapy are derived from the microdosimetric kinetic model (MKM) in Japan and the local effect model (LEM) in Europe ...
T J Dahle, G Magro, K S Ytre-Hauge, C H Stokkevåg, K Choi, A Mairani   +5 more
openaire   +2 more sources

Characterizing Radiation Effectiveness in Ion Beam Therapy Part I: Introduction and Biophysical Modeling of RBE Using the LEMIV

Frontiers in Physics, 2020
The specific advantages of ion beams for application in tumor therapy are attributed to their different macroscopic and microscopic energy deposition pattern as compared to conventional photon radiation.
Michael Scholz, Thomas Friedrich, Giulio Magrin, Paolo Colautti, Aleksandra Ristić-Fira, Ivan Petrović   +5 more
doaj   +1 more source

LET measurements in proton and helium-ion beams of therapeutic energies using a silicon pixel detector towards a tool for quality assurance. [PDF]

Med Phys
Abstract Background As advanced treatment plans increasingly include optimizing both dose and linear energy transfer (LET), there is a growing demand for tools to measure LET in clinical settings. Although various detection systems have been investigated in this pursuit, the scarcity of detectors capable of providing per‐ion data for a fast and ...
Hamad Y, Sari FK, Félix-Bautista R, Martišíková M, Mairani A, Gehrke T.   +5 more
europepmc   +2 more sources

Linking Microdosimetric Measurements to Biological Effectiveness in Ion Beam Therapy: A Review of Theoretical Aspects of MKM and Other Models

Frontiers in Physics, 2021
Different qualities of radiation are known to cause different biological effects at the same absorbed dose. Enhancements of the biological effectiveness are a direct consequence of the energy deposition clustering at the scales of DNA molecule and cell ...
V. E. Bellinzona, V. E. Bellinzona, F. Cordoni, F. Cordoni, M. Missiaggia, M. Missiaggia, F. Tommasino, F. Tommasino, E. Scifoni, C. La Tessa, C. La Tessa, A. Attili   +11 more
doaj   +1 more source

'Dirty dose'-based proton variable RBE models - performance assessment on in vitro data. [PDF]

Med Phys
Abstract Background In clinical proton radiotherapy, a constant relative biological effectiveness (RBE) of 1.1 is typically applied. Due to abundant evidence of variable RBE effects from in vitro data, multiple variable RBE models have been suggested, typically by describing the α$\alpha$ and β$\beta$ parameters in the linear quadratic (LQ) model as a ...
Kalholm F, Toma-Dasu I, Traneus E.
europepmc   +2 more sources