Results 31 to 40 of about 483 (145)

Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions

Physics and Imaging in Radiation Oncology, 2019
The relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV ...
Caterina Monini, Gersende Alphonse, Claire Rodriguez-Lafrasse, Étienne Testa, Michaël Beuve   +4 more
doaj   +1 more source

Clonogenic Survival RBE Calculations in Carbon Ion Therapy: The Importance of the Absolute Values of α and β in the Photon Dose-Response Curve and a Strategy to Mitigate Their Anticorrelation

Quantum Beam Science, 2023
The computation of the relative biological effectiveness (RBE) is a fundamental step in the planning of cancer radiotherapy treatments with accelerated ions.
Alessio Parisi, Chris J. Beltran, Keith M. Furutani   +2 more
doaj   +1 more source

Advancement of microdosimetric kinetic model in heavy-ion radiotherapy

Journal of Physics: Conference Series, 2020
Abstract To date, more than 11,000 cancer patients have been treated with therapeutic carbon-ion beams at the National Institute of Radiological Sciences (NIRS). In the treatment planning system, the biological effectiveness of the therapeutic carbon-ion beams has been predicted based on the microdosimetric kinetic (MK) model.
openaire   +1 more source

Brainstem NTCP and Dose Constraints for Carbon Ion RT—Application and Translation From Japanese to European RBE-Weighted Dose

Frontiers in Oncology, 2020
Background and PurposeThe Italian National Center of Oncological Hadrontherapy (CNAO) has applied dose constraints for carbon ion RT (CIRT) as defined by Japan’s National Institute of Radiological Sciences (NIRS).
Jon Espen Dale, Jon Espen Dale, Silvia Molinelli, Barbara Vischioni, Viviana Vitolo, Maria Bonora, Giuseppe Magro, Andrea Mairani, Andrea Mairani, Azusa Hasegawa, Azusa Hasegawa, Tatsuya Ohno, Olav Dahl, Francesca Valvo, Piero Fossati, Piero Fossati   +15 more
doaj   +1 more source

Modelling the HPRT-gene mutation induction of particle beams: systematic in vitro data collection, analysis and microdosimetric kinetic model implementation

Physics in Medicine & Biology, 2022
Abstract Objective. Since the early years, particle therapy treatments have been associated with concerns for late toxicities, especially secondary cancer risk (SCR). Nowadays, this concern is related to patients for whom long-term survival is expected (e.g. breast cancer, lymphoma, paediatrics).
Andrea Attili, Emanuele Scifoni, Francesco Tommasino   +2 more
openaire   +2 more sources

Dosimetric and Clinical Risk Factors for the Development of Maxillary Osteoradionecrosis in Adenoid Cystic Carcinoma (ACC) Patients Treated With Carbon Ion Radiotherapy

Frontiers in Oncology, 2022
BackgroundThe present study aims to evaluate dosimetric and clinical risk factors for the development of maxillary osteoradionecrosis (ORN) in head and neck adenoid cystic carcinoma (ACC) patients treated with carbon ion radiotherapy (CIRT ...
Barbara Vischioni, Stefania Russo, Martino Meuli, Maria Bonora, Sara Ronchi, Rossana Ingargiola, Anna Maria Camarda, Anna Maria Camarda, Sara Imparato, Lorenzo Preda, Lorenzo Preda, Lorenzo Preda, Mario Ciocca, Silvia Molinelli, Ester Orlandi   +14 more
doaj   +1 more source

Spot-Scanning Hadron Arc (SHArc) Therapy: A Study With Light and Heavy Ions

Advances in Radiation Oncology, 2021
Purpose: To evaluate the clinical potential of spot-scanning hadron arc (SHArc) therapy with a heavy-ion gantry. Methods and Materials: A series of in silico studies was conducted via treatment plan optimization in FRoG and the RayStation TPS to compare ...
Stewart Mein, PhD, Thomas Tessonnier, PhD, Benedikt Kopp, MS, Semi Harrabi, MD, Amir Abdollahi, MD, PhD, Jürgen Debus, MD, PhD, Thomas Haberer, PhD, Andrea Mairani, PhD   +7 more
doaj   +1 more source

Reproducing the NIRS-QST Clinical Dose Calculations for Carbon Ion Radiotherapy Using Microdosimetric Probability Density Distributions

Radiation
Ion radiotherapy requires accurate relative biological effectiveness (RBE) calculations to account for the markedly different biological effects of ions compared to photons.
Alessio Parisi, Keith M. Furutani, Shannon Hartzell, Chris J. Beltran   +3 more
doaj   +1 more source

Impact of Microdosimetric Modeling on Computation of Relative Biological Effectiveness for Carbon Ion Radiotherapy

Radiation
Microdosimetry plays a critical role in particle therapy by quantifying energy deposition within microscopic domains to assess biological effects. This study evaluates the influence of different microdosimetric functions (MFs) and domain geometries (DGs)
Shannon Hartzell, Keith M. Furutani, Alessio Parisi, Tatsuhiko Sato, Yuki Kase, Christian Deglow, Thomas Friedrich, Chris J. Beltran   +7 more
doaj   +1 more source

Conversion and validation of rectal constraints for prostate carcinoma receiving hypofractionated carbon-ion radiotherapy with a local effect model

Radiation Oncology, 2021
Background The study objective was to establish the local effect model (LEM) rectum constraints for 12-, 8-, and 4-fraction carbon-ion radiotherapy (CIRT) in patients with localized prostate carcinoma (PCA) using microdosimetric kinetic model (MKM ...
Weiwei Wang, Ping Li, Yinxiangzi Sheng, Zhijie Huang, Jingfang Zhao, Zhengshan Hong, Kambiz Shahnazi, Guo-Liang Jiang, Qing Zhang   +8 more
doaj   +1 more source