Results 41 to 50 of about 483 (145)

Beyond a constant proton relative biological effectiveness: A survey of clinical and research perspectives among proton institutions in Europe and the United States. [PDF]

J Appl Clin Med Phys
Abstract Purpose Although proton relative biological effectiveness (RBE) depends on factors like linear energy transfer (LET), tissue properties, dose, and biological endpoint, a constant RBE of 1.1 is recommended in clinical practice. This study surveys proton institutions to explore activities using functionalities beyond a constant proton RBE ...
Ödén J, Eriksson K, Kaushik S, Traneus E.   +3 more
europepmc   +2 more sources

A model for relative biological effectiveness of therapeutic proton beams based on a global fit of cell survival data

Scientific Reports, 2017
We introduce an approach for global fitting of the recently published high-throughput and high accuracy clonogenic cell-survival data for therapeutic scanned proton beams.
Ramin Abolfath, Christopher R. Peeler, Mark Newpower, Lawrence Bronk, David Grosshans, Radhe Mohan   +5 more
doaj   +1 more source

Influence of radiotherapy dose rate on gold nanoparticle‐induced radiosensitization from high dose‐rate brachytherapy and external beam therapy

Medical Physics, Volume 53, Issue 3, March 2026.
Abstract Background Associated normal tissue toxicity from current radiotherapy (RT) treatments limits effective dose escalation in the tumor to achieve nominal treatment results. Gold nanoparticles (GNPs) as radiosensitizing agents to locally increase photoelectron production have gained interest as a safe and viable method to improve therapeutic ...
Daniel Cecchi, Nolan Jackson, Sacha Freeman, Kieren O'Neil, Mehran Goharian, Wayne Beckham, Devika B. Chithrani   +6 more
wiley   +1 more source

Model assembly for estimating cell surviving fraction for both targeted and nontargeted effects based on microdosimetric probability densities.

PLoS ONE, 2014
We here propose a new model assembly for estimating the surviving fraction of cells irradiated with various types of ionizing radiation, considering both targeted and nontargeted effects in the same framework.
Tatsuhiko Sato, Nobuyuki Hamada
doaj   +1 more source

Application of intrahepatic fiducial markers in carbon ion radiotherapy for pancreatic cancer—Achieving higher precision treatment

Journal of Applied Clinical Medical Physics, Volume 27, Issue 1, January 2026.
Abstract Background Carbon‐ion radiotherapy (CIRT) delivers highly conformal tumor doses while sparing surrounding organs‐at‐risk (OAR). However, density variations along the beam path and interfractional target motion can reduce target coverage and expose OAR to high doses.
Junya Nagata, Yohsuke Kusano, Masataka Komori, Yoshiki Takayama, Shogo Kurokawa, Atsushi Ito, Tadashi Kamada, Daisaku Yoshida, Shohei Kawashiro, Hiroyuki Katoh   +9 more
wiley   +1 more source

Establishment of a new three-dimensional dose evaluation method considering variable relative biological effectiveness and dose fractionation in proton therapy combined with high-dose-rate brachytherapy

Journal of Medical Physics, 2019
Purpose: The purpose of this study is to evaluate the influence of variable relative biological effectiveness (RBE) of proton beam and dose fractionation has on dose distribution and to establish a new three-dimensional dose evaluation method for proton ...
Daisuke Kobayashi, Tomonori Isobe, Kenta Takada, Yutaro Mori, Hideyuki Takei, Hiroaki Kumada, Satoshi Kamizawa, Tetsuya Tomita, Eisuke Sato, Hiroshi Yokota, Takeji Sakae   +10 more
doaj   +1 more source

Assessment of the impact of CT scan protocols on carbon ion radiotherapy treatment planning

Journal of Applied Clinical Medical Physics, Volume 26, Issue 9, September 2025.
Abstract Purpose The purpose of this study was to quantify the impact of computed tomography (CT) scan protocols and CT scanner on carbon ion radiotherapy treatment planning Material and Methods A table was created for each of the five parameters to relate CT values to stopping power (SPR) (CT‐SPR conversion table).
Yuya Miyasaka, Hikaru Souda, Yasuhito Hagiwara, Hiroko Akamatsu, Mayumi Harada, Takashi Kaneko, Hongbo Chai, Miyu Ishizawa, Hiraku Sato, Masashi Koto, Takeo Iwai   +10 more
wiley   +1 more source

Results of a Geant4 benchmarking study for bio‐medical applications, performed with the G4‐Med system

Medical Physics, Volume 52, Issue 5, Page 2707-2761, May 2025.
Abstract Background Geant4, a Monte Carlo Simulation Toolkit extensively used in bio‐medical physics, is in continuous evolution to include newest research findings to improve its accuracy and to respond to the evolving needs of a very diverse user community.
Pedro Arce, Jay W. Archer, Lorenzo Arsini, Alexander Bagulya, David Bolst, Jeremy M. C. Brown, Barbara Caccia, Andrew Chacon, Giuseppe Antonio Pablo Cirrone, Miguel Antonio Cortés‐Giraldo, Dean Cutajar, Giacomo Cuttone, Paolo Dondero, Andrea Dotti, Bruce Faddegon, Serena Fattori, Christian Fedon, Susanna Guatelli, Akihiro Haga, Sebastien Incerti, Vladimir Ivanchenko, Dmitri Konstantinov, Ioanna Kyriakou, Albert Le, Zhuxin Li, Michel Maire, Alessandra Malaroda, Carlo Mancini‐Terracciano, Alfonso Mantero, Claire Michelet, Giuliana Milluzzo, Francesca Nicolanti, Mihaly Novak, Chihiro Omachi, Luciano Pandola, Jake Harold Pensavalle, Álvaro Perales, Yann Perrot, Giada Petringa, Silvia Pozzi, José Manuel Quesada, José Ramos‐Méndez, Francesco Romano, Anatoly B. Rosenfeld, Mitra Safavi‐Naeini, Dousatsu Sakata, Luis G. Sarmiento, Takashi Sasaki, Yoshihide Sato, Alberto Sciuto, Ioannis Sechopoulos, Edward C. Simpson, Ronny Stanzani, Alessandra Tomal, Toshiyuki Toshito, Hoang Ngoc Tran, Christopher White, Dennis H. Wright   +57 more
wiley   +1 more source

Investigation of factors related to treatment planning of x‐ray SBRT and scanning carbon‐ion radiation therapy for early‐stage lung cancer patients

Journal of Applied Clinical Medical Physics, Volume 26, Issue 4, April 2025.
Abstract This study aimed to compare the treatment plans of x‐ray SBRT and scanning carbon ion radiation therapy (CIRT) for localized lung tumors, and to evaluate the dose dependence of tumor size tumor‐to‐heart distance. For phantom verification, we used a chest phantom with a spherical simulated tumor.
Yuya Miyasaka, Sung Hyun Lee, Hikaru Souda, Hongbo Chai, Miyu Ishizawa, Takuya Ono, Takashi Ono, Hiraku Sato, Takeo Iwai   +8 more
wiley   +1 more source

Dose–Volume Constraints for Thoracic, Abdominal, and Pelvic Carbon Ion Radiotherapy: A Literature Review

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Applying dose–volume constraints is extremely important in ensuring the safe use of radiotherapy. However, constraints for carbon ion radiotherapy (CIRT) have not been established yet. This review aims to summarize dose–volume constraints for thoracic, abdominal, and pelvic CIRT that have been identified through previous research ...
Maria Varnava, Mutsumi Tashiro, Masahiko Okamoto, Ken Ando, Nobutero Kubo, Hidemasa Kawamura, Masahiro Onishi, Kei Shibuya, Takuya Kumazawa, Takeru Ohtaka, Tatsuya Ohno   +10 more
wiley   +1 more source