Results 51 to 60 of about 483 (145)

Commissioning of a commercial treatment planning system for scanned carbon‐ion radiotherapy

Journal of Applied Clinical Medical Physics, Volume 26, Issue 3, March 2025.
Abstract Purpose To commission the RayStation (RS) TPS (treatment planning system) for scanned CIRT (carbon‐ion radiotherapy) utilizing pencil beam algorithms (PBv4.2). Methods The beam model commissioning entailed employing 1D single beams and 2D monoenergetic fields to validate spot profiles with films, assess beam range using Peakfinder measurements,
Wei Sun, Weiwei Wang, Zhijie Huang, Jingfang Zhao   +3 more
wiley   +1 more source

Relation between Lineal Energy Distribution and Relative Biological Effectiveness for Photon Beams according to the Microdosimetric Kinetic Model [PDF]

Journal of Radiation Research, 2011
Our cell survival data showed the obvious dependence of RBE on photon energy: The RBE value for 200 kV X-rays was approximately 10% greater than those for mega-voltage photon beams. In radiation therapy using mega-voltage photon beams, the photon energy distribution outside the field is different with that in the radiation field because of a large ...
H. Okamoto, T. Kanai, Y. Kase, Y. Matsumoto, Y. Furusawa, Y. Fujita, H. Saitoh, J. Itami, T. Kohno   +8 more
openaire   +2 more sources

Novel radiation quality metrics accounting for proton energy spectra for RBE proton models

Medical Physics, Volume 51, Issue 8, Page 5773-5782, August 2024.
Abstract Background For proton therapy, a relative biological effectiveness (RBE) of 1.1 is widely applied clinically. However, due to abundant evidence of variable RBE in vitro, and as suggested in studies of patient outcomes, RBE might increase by the end of the proton tracks, as described by several proposed variable RBE models.
Fredrik Kalholm, Iuliana Toma‐Dasu, Erik Traneus, Niels Bassler   +3 more
wiley   +1 more source

The sensitivity of radiobiological models in carbon ion radiotherapy (CIRT) and its consequences on the clinical treatment plan: Differences between LEM and MKM models

Journal of Applied Clinical Medical Physics, Volume 25, Issue 7, July 2024.
Abstract Purpose Carbon ion radiotherapy (CIRT) relies on relative biological effectiveness (RBE)‐weighted dose calculations. Japanese clinics predominantly use the microdosimetric kinetic model (MKM), while European centers utilize the local effect model (LEM). Despite both models estimating RBE‐distributions in tissue, their physical and mathematical
Joanna Góra, Sarah Grosshagauer, Piero Fossati, Marta Mumot, Markus Stock, Mansure Schafasand, Antonio Carlino   +6 more
wiley   +1 more source

Evaluation of the availability of single‐position treatment with a rotating gantry and the validity of deformable image registration dose assessment for pancreatic cancer carbon‐ion radiotherapy

Journal of Applied Clinical Medical Physics, Volume 25, Issue 6, June 2024.
Abstract Background This study aimed to evaluate the clinical acceptability of rotational gantry‐based single‐position carbon‐ion radiotherapy (CIRT) to reduce the gastrointestinal (GI) dose in pancreatic cancer. We also evaluated the usefulness of the deformable image registration (DIR)‐based dosimetry method for CIRT.
Yuya Miyasaka, Shohei Kawashiro, Sung Hyun Lee, Hikaru Souda, Mayumi Ichikawa, Hongbo Chai, Miyu Ishizawa, Takuya Ono, Hiraku Sato, Takeo Iwai   +9 more
wiley   +1 more source

Dose averaged linear energy transfer optimization for large sacral chordomas in carbon ion therapy

Medical Physics, Volume 51, Issue 6, Page 3950-3960, June 2024.
Abstract Background Carbon ion beams are well accepted as densely ionizing radiation with a high linear energy transfer (LET). However, the current clinical practice does not fully exploit the highest possible dose‐averaged LET (LETd) and, consequently, the biological potential in the target.
Mansure Schafasand, Andreas Franz Resch, Ankita Nachankar, Joanna Góra, Giovanna Martino, Erik Traneus, Lars Glimelius, Dietmar Georg, Piero Fossati, Antonio Carlino, Markus Stock   +10 more
wiley   +1 more source

Microdosimetric Evaluation of Physical and Biological Quantities due to Linear Energy Transfer in Proton Therapy Using Monte Carlo Simulation [PDF]

Iranian South Medical Journal
Background: In proton therapy, it is imperative to take the distribution of both the physical absorbed dose and the biological dose into account. Therefore, phenomenological models and a biophysical model such as microdosimetric kinetic model (MKM) have ...
Hossien Taghipour, Seyed Mohammad Motevalli, Paivand Taherparvar   +2 more
doaj  

Robustness of carbon‐ion radiotherapy against DNA damage repair associated radiosensitivity variation based on a biophysical model

Medical Physics, Volume 51, Issue 5, Page 3782-3795, May 2024.
Abstract Background Interpatient variation of tumor radiosensitivity is rarely considered during the treatment planning process despite its known significance for the therapeutic outcome. Purpose To apply our mechanistic biophysical model to investigate the biological robustness of carbon ion radiotherapy (CIRT) against DNA damage repair interference ...
Hans Liew, Thomas Tessonnier, Stewart Mein, Giuseppe Magro, Lars Glimelius, Elias Coniavitis, Thomas Held, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Ivana Dokic, Andrea Mairani   +11 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

A deep learning model for predicting the modified micro-dosimetric kinetic model-based dose and the dose-averaged linear energy transfer for prostate cancer in carbon ion therapy

Physics and Imaging in Radiation Oncology
Adaptive carbon ion radiotherapy for localized prostate cancer requires accurate evaluation of biological dose and dose-averaged linear energy transfer (LETd) changes.
Liwen Zhang, Weiwei Wang, Ping Li, Qing Zhang, Rongcheng Han   +4 more
doaj   +1 more source