A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness? [PDF]
Radiother Oncol, 2023 Suárez-García D +2 more
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Erratum to "A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness?" [Radiother. Oncol. 185 (2023) 109730]. [PDF]
Radiother Oncol, 2023 Suárez-García D +2 more
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The Mayo Clinic Florida Microdosimetric Kinetic Model of Clonogenic Survival: Application to Various Repair-Competent Rodent and Human Cell Lines. [PDF]
Int J Mol Sci, 2022 Parisi A, Beltran CJ, Furutani KM.
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Applied SciencesA constant proton relative biological effectiveness (RBE) of 1.1 for tumor control is currently used in proton therapy treatment planning. However, in vitro, in vivo and clinical experiences indicate that proton RBE varies with kinetic energy and ...
Dimitris Dalalas +5 more
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Stochastic Microdosimetric Kinetic model for hypo-fractionated multi-ion therapy
Stochastic Microdosimetric Kinetic model for hypo-fractionated multi-ion therapyThe microdosimetric kinetic (MK) model is a biological model used to predict cell-survival fractions from the specific energy absorbed by a microscopic subnuclear structure, domain, for various radiations. The MK model has been used in clinical treatments of carbon-ion radiotherapy at NIRS.
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Adaptation of the microdosimetric kinetic model to hypoxia
Adaptation of the microdosimetric kinetic model to hypoxiaIon beams present a potential advantage in terms of treatment of lesions with hypoxic regions. In order to use this potential, it is important to accurately model the cell survival of oxic as well as hypoxic cells. In this work, an adaptation of the microdosimetric kinetic (MK) model making it possible to account for cell hypoxia is presented.
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Advancement of microdosimetric kinetic model in heavy-ion radiotherapy
Advancement of microdosimetric kinetic model in heavy-ion radiotherapyTo date, more than 11,000 cancer patients have been treated with therapeutic carbon-ion beams at the National Institute of Radiological Sciences (NIRS). In the treatment planning system, the biological effectiveness of the therapeutic carbon-ion beams has been predicted based on the microdosimetric kinetic (MK) model.
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Adaptation of Stochastic Microdosimetric Kinetic Model for Charged-Particle Therapy Treatment PlanningPurpose: The microdosimetric kinetic (MK) model underestimates the cell-survival fractions for high linear energy transfer (LET) and high dose irradiations. To address the issue, the MK model was extended to the stochastic microdosimetric kinetic (SMK) model.
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Validation of the physical and RBE-weighted dose estimator based on PHITS coupled with a microdosimetric kinetic model for proton therapy. [PDF]
J Radiat Res, 2018 Takada K +6 more
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Relative biological effectiveness study of Lipiodol based on microdosimetric-kinetic model
Relative biological effectiveness study of Lipiodol based on microdosimetric-kinetic modelObjectives: We examine the contrast agent Lipiodol effect on the relative biological effectiveness (RBE) values for flattening filter free (FFF) and flattening filter (FF) beams of 6 MV-Xray (6 MVX) and 10 MVX. Methods: Lipiodol was placed at 5 cm depth in water. According to the microdosimetric kinetic model, the RBE values for killing the human liver
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