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Association Between Genotoxic Effects of Ageing Dental Restorations and Micronuclei in Oral Mucosal Cells [PDF]
MedicinaBackground and Objectives: Dental restorations can be composed of various materials, including amalgams and methacrylate-based resins. The health risks associated with the components of the restorative materials have always been a concern, even more so ...
Csilla Benedek +9 more
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Scientific Reports, 2021 The micronucleus is known to be a biomarker for genomic instability, which is a hallmark of tumors and aging. Normally, micronuclei are produced by segregation errors and mechanical stresses arising from dividing or migrating cells, leading to activation
Sarasa Yano +6 more
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DNA content, repeatome composition and origin of the Zea mays micronuclei [PDF]
Scientific ReportsMicronuclei originate from DNA damage generated by clastogenic and/or by aneugenic effects. Depending on the pattern of damage, they may have distinct genomic origin and composition.
Nathália Vállery Tostes +5 more
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Cancer cells’ chamber of secrets: the link between micronuclei, chromothripsis and malignancy
Open BiologyMicronuclei exhibit defective proteomes rendering their chromatin vulnerable to fragmentation. This fragmentation process, known as chromothripsis, promotes tumorigenesis by catalysing the activation of oncogenes and the silencing of tumor suppressors ...
Truman Raleigh Mcneil +2 more
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Micronuclei in Diabetics and Smokers
Research Journal of Pharmacy and Technology, 2015 Aim: This article reviews the MN assay with respect to oral buccal mucosa, which has been used since the 1980s to demonstrate the characteristics of micronuclei and frequency of micronuclei in smokers and diabetes. Objective: To compare the frequency of micronuclei and metanucleated anomalies in the oral mucosa of smokers and diabetes.
S Bharathi, Gheena
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Micronuclei, reproduction and child health [PDF]
Mutation Research/Reviews in Mutation Research, 2021 The current review looks for relationships between results from biomarker studies with micronucleus and health effects related to reproduction and children. In adults, an age related increase in MN is well known as well as associations with environmental exposures especially air pollution from traffic and smoking.
Knudsen, Lisbeth E. +1 more
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Emergence of micronuclei and their effects on the fate of cells under replication stress. [PDF]
PLoS ONE, 2010 The presence of micronuclei in mammalian cells is related to several mutagenetic stresses. In order to understand how micronuclei emerge, behave in cells, and affect cell fate, we performed extensive time-lapse microscopy of HeLa H2B-GFP cells in the ...
Koh-ichi Utani +3 more
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Atypical monoblasts with micronuclei [PDF]
Blood, 2017 ![Figure][1] A 61-year-old woman with a history of hepatic hemangioma and cholecystectomy developed epigastric pain for several weeks. Her blood tests showed hemoglobin 74 g/L, platelets 127 × 109/L, and white blood cells 104.6 × 109/L with 51% monoblasts.
Bouvier, Sylvie, Martin, Mélanie
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Micronuclei and pesticide exposure [PDF]
Mutagenesis, 2010 Micronucleus (MN) is a biomarker widely used in biomonitoring studies carried out to determine the genetic risk associated to pesticide exposure. Many in vitro and in vivo studies, as well as epidemiological approaches, have demonstrated the ability of certain chemical pesticides to produce genetic effects including cancer and other chronic pathologies
Claudia, Bolognesi +3 more
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Autophagic removal of micronuclei [PDF]
Cell Cycle, 2012 Macroautophagy is known to participate in the quality control and turnover of cytoplasmic organelles, yet there is little evidence that macroautophagy targets nuclei in mammalian cells. Here, we investigated whether autophagy may target micronuclei, which arise as a result of deficient bipolar chromosome segregation in cells exposed to cell cycle ...
Santiago, Rello-Varona +11 more
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