Results 11 to 20 of about 32,768 (229)
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei
Nature Communications, 2023 DNA damage-induced micronuclei are linked to downstream viral signalling through the cGAS pattern recognition receptor. Here, the authors identify features of micronuclei chromatin that determine cGAS-MN recruitment and associated pathway activation.
Kate M. MacDonald +5 more
doaj +2 more sources
Cell Death and Disease, 2022 Micronuclei are DNA-containing structures separate from the nucleus found in cancer cells. Micronuclei are recognized by the immune sensor axis cGAS/STING, driving cancer metastasis.
Aladin Haimovici +17 more
doaj +2 more sources
Chromothripsis from DNA damage in micronuclei [PDF]
Nature, 2015 Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes.
Zhang, Cheng-Zhong +7 more
openaire +4 more sources
Rapid and automatic detection of micronuclei in binucleated lymphocytes image
Scientific Reports, 2022 Cytokinesis block micronucleus (CBMN) assay is a widely used radiation biological dose estimation method. However, the subjectivity and the time-consuming nature of manual detection limits CBMN for rapid standard assay. The CBMN analysis is combined with
Xiang Shen +6 more
doaj +2 more sources
Scientific Reports, 2019 Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease with no known etiology. The formation of pathological protein inclusions, including RNA-binding proteins such as TDP-43 and rho guanine nucleotide exchange factor (
Cristian A. Droppelmann +4 more
doaj +2 more sources
Frontiers in Oncology, 2018 Radiation-induced chromosomal aberrations represent an early marker of late effects, including cell killing and transformation. The measurement of cytogenetic damage in tissues, generally in blood lymphocytes, from patients treated with radiotherapy has ...
Marco Durante, Silvia C. Formenti
doaj +2 more sources
Epigenetic dysregulation from chromosomal transit in micronuclei
bioRxiv, 2022 Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers^ 1 – 4 , but whether they are mechanistically linked is unknown.
Albert S. Agustinus +23 more
semanticscholar +1 more source
Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Cancer chemotherapeutic drugs that induce mitotic errors may cause tumor regression in part through the induction of interferon signaling. To test this idea, we measured the ability of antimitotic drugs with different mechanisms to activate ...
Patrick J. Flynn, P. Koch, T. Mitchison
semanticscholar +1 more source
Plant Cytogenetics in the Micronuclei Investigation—The Past, Current Status, and Perspectives
International Journal of Molecular Sciences, 2022 Cytogenetic approaches play an essential role as a quick evaluation of the first genetic effects after mutagenic treatment. Although labor-intensive and time-consuming, they are essential for the analyses of cytotoxic and genotoxic effects in mutagenesis
J. Kwasniewska, A. Bara
semanticscholar +1 more source
Incidence of micronuclei in pregnant women and cord blood samples before and after the bombing of Serbia [PDF]
Archive of Oncology, 2004 BACKGROUND: This study provides the data regarding monitoring of population using CB-micronuclei assay in the period 1995-2001 in Serbia. The target groups consisted of 45 pregnant women of mean age 34.3(6.56) years, unaware of being exposed to chemicals
Stanković Miroslava +2 more
doaj +1 more source