Results 11 to 20 of about 37,562 (240)
Heliyon, 2023 In the modern developing society, application of radiation has increased extensively. With significant improvement in the radiation protection practices, exposure to human could be minimized substantially, but cannot be avoided completely.
J. Vijayalakshmi +6 more
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The correlation between micronuclei count and smoking behavior: A hospital-based study
Journal of Oral Research, 2020 Background: Micronucleus is a microscopically visible cyto-plasmic chromatin mass in the extranuclear vicinity, originating from aberrant mitosis, which consists of eccentric chromosomes that have failed to reach spindle poles during mitosis. The present
Lakshmi Balraj +2 more
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Cell Death and Disease, 2022 Micronuclei are DNA-containing structures separate from the nucleus found in cancer cells. Micronuclei are recognized by the immune sensor axis cGAS/STING, driving cancer metastasis.
Aladin Haimovici +17 more
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Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication [PDF]
, 2017 Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression.
Beckerman +14 more
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A study on micronucleus frequency in lymphocytes by flow cytometry to assess genetic damage in Polycystic ovarian syndrome (PCOS) [PDF]
Al Ameen Journal of Medical Sciences, 2022 Background: Micronucleus is a small additional nucleus formed due to chromosomal loss or fragmentation and frequently used as a biomarker of genomic damage. Genetic damage and cancer susceptibility are notable concerns in PCOS.
R. Showri, T. Rajini
doaj
Rapid and automatic detection of micronuclei in binucleated lymphocytes image
Scientific Reports, 2022 Cytokinesis block micronucleus (CBMN) assay is a widely used radiation biological dose estimation method. However, the subjectivity and the time-consuming nature of manual detection limits CBMN for rapid standard assay. The CBMN analysis is combined with
Xiang Shen +6 more
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Linking Micronuclei to Chromosome Fragmentation [PDF]
Cell, 2015 Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei ...
Hatch, Emily M., Hetzer, Martin W.
openaire +2 more sources
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei
Nature Communications, 2023 DNA damage-induced micronuclei are linked to downstream viral signalling through the cGAS pattern recognition receptor. Here, the authors identify features of micronuclei chromatin that determine cGAS-MN recruitment and associated pathway activation.
Kate M. MacDonald +5 more
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Giemsa versus acridine orange staining in the fish micronucleus assay and validation for use in water quality monitoring [PDF]
, 2011 This study concerns a comparative analysis of the acridineorange and Giemsastaining procedures for the fish erythrocyte micronucleusassay. The goal was to optimize the assay in the context of field watermonitoring. Fish (Carassius carassius) were exposed
Gauthier, Laury +5 more
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Automated Detection of Binucleated Cell and Micronuclei using CellProfiler 2.0 Software
Hayati Journal of Biosciences, 2013 Micronucleus assay in human peripheral lymphocytes usually used to assess chromosomal damage. Manual scoring of micronuclei can be time consuming and large numbers of binucleated cells have to be analyzed to obtain statistically relevant data. Automation
DWI RAMADHANI, SOFIATI PURNAMI
doaj +1 more source