Results 21 to 30 of about 32,768 (229)
CGAS is a micronucleophagy receptor for the clearance of micronuclei
Autophagy, 2021 Micronuclei are constantly considered as a marker of genome instability and very recently found to be a trigger of innate immune responses. An increased frequency of micronuclei is associated with many diseases, but the mechanism underlying the ...
Mengmeng Zhao +10 more
semanticscholar +1 more source
Heliyon, 2023 In the modern developing society, application of radiation has increased extensively. With significant improvement in the radiation protection practices, exposure to human could be minimized substantially, but cannot be avoided completely.
J. Vijayalakshmi +6 more
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Archives of Toxicology, 2022 Although micronuclei are well-known biomarkers of genotoxic damage, the biological consequences of micronucleus induction are only poorly understood.
H. Reimann, H. Stopper, H. Hintzsche
semanticscholar +1 more source
Micronuclei-based model system reveals functional consequences of chromothripsis in human cells
eLife, 2019 Cancer cells often harbor chromosomes in abnormal numbers and with aberrant structure. The consequences of these chromosomal aberrations are difficult to study in cancer, and therefore several model systems have been developed in recent years.
Maja Kneissig +13 more
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The correlation between micronuclei count and smoking behavior: A hospital-based study
Journal of Oral Research, 2020 Background: Micronucleus is a microscopically visible cyto-plasmic chromatin mass in the extranuclear vicinity, originating from aberrant mitosis, which consists of eccentric chromosomes that have failed to reach spindle poles during mitosis. The present
Lakshmi Balraj +2 more
doaj +1 more source
International Journal of Environmental Research and Public Health, 2021 The presence of micronuclei in oral epithelial cells is considered a marker of genotoxicity, which can be identified using exfoliative cytology. The aim of this study was to investigate cytotoxic damage through the evaluation of micronuclei in the oral ...
Anca Maria Pop +3 more
semanticscholar +1 more source
A study on micronucleus frequency in lymphocytes by flow cytometry to assess genetic damage in Polycystic ovarian syndrome (PCOS) [PDF]
Al Ameen Journal of Medical Sciences, 2022 Background: Micronucleus is a small additional nucleus formed due to chromosomal loss or fragmentation and frequently used as a biomarker of genomic damage. Genetic damage and cancer susceptibility are notable concerns in PCOS.
R. Showri, T. Rajini
doaj
Journal of Cell Biology, 2021 Kif18a mutant mice produce micronuclei following segregation of unaligned chromosomes but do not spontaneously form tumors. KIF18A KO cells form stable micronuclear envelopes around lagging chromosomes located near the spindle pole and outside the ...
Leslie A. Sepaniac +5 more
semanticscholar +1 more source
Linking Micronuclei to Chromosome Fragmentation [PDF]
Cell, 2015 Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei ...
Hatch, Emily M., Hetzer, Martin W.
openaire +2 more sources
Automated Detection of Binucleated Cell and Micronuclei using CellProfiler 2.0 Software
Hayati Journal of Biosciences, 2013 Micronucleus assay in human peripheral lymphocytes usually used to assess chromosomal damage. Manual scoring of micronuclei can be time consuming and large numbers of binucleated cells have to be analyzed to obtain statistically relevant data. Automation
DWI RAMADHANI, SOFIATI PURNAMI
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