Results 21 to 30 of about 37,562 (240)

Paternal cyclophosphamide exposure induces the formation of functional micronuclei during the first zygotic division. [PDF]

PLoS ONE, 2011
Paternal exposures to cancer chemotherapeutics or environmental chemicals may have adverse effects on progeny outcome that are manifested in the preimplantation embryo.
Lisanne Grenier, Bernard Robaire, Barbara F Hales   +2 more
doaj   +1 more source

The micronucleus assay as a biological dosimeter of in vivo ionising radiation exposure [PDF]

, 2010
Biological dosimetry, based on the analysis of micronuclei (MN) in the cytokinesis-block micronucleus (CBMN) assay can be used as an alternative method for scoring dicentric chromosomes in the field of radiation protection.
Fenech, Michel, Thierens, Hubert, Vral, Anne   +2 more
core   +2 more sources

Chromothripsis from DNA damage in micronuclei [PDF]

Nature, 2015
Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes.
Zhang, Cheng-Zhong, Cornils, Hauke, Jackson, Emily K., Spektor, Alexander, Francis, Joshua M., Liu, Shiwei, Meyerson, Matthew, Pellman, David   +7 more
openaire   +3 more sources

Evaluation of the cytotoxic and genotoxic potential of Khat (Catha edulis Forsk) extracts on human T lymphoblastoid cell line [PDF]

, 2009
This paper reports on an investigation of the cytotoxic and genotoxic potential of khat extract using a human T lymphoblastoid cell line (CEM). Exponentially growing CEM cells were cultured for 12 h in the presence of khat extract (0-2000 μg ml-1 ...
Al-Meshal, Al-Meshal, Barnett, C.N. Fokunang ., C.R. Barnett ., Fenech, Gunaid, Hammouda, Kabarity, Kalix, Kamel, Morton, O’Gara, O’Gara, P.T. Tomkins ., Reed, S.S. Barkwan, Sakagam, Sharma, Y.A. Barnett ., Zheng   +20 more
core   +1 more source

Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures

Environmental Health, 2017
Background Ionizing radiation is a well-known carcinogen. Chromosome aberrations, and in particular micronuclei represent an early biological predictor of cancer risk.
D. Bazyka, S. C. Finch, I. M. Ilienko, O. Lyaskivska, I. Dyagil, N. Trotsiuk, N. Gudzenko, V. V. Chumak, K. M. Walsh, J. Wiemels, M. P. Little, L.B. Zablotska   +11 more
doaj   +1 more source

Oral Acute Toxicity and Genotoxicity of Heteroctenus junceus Scorpion Venom. [PDF]

Vet Med Sci
The Heteroctenus junceus scorpion venom is a very popular natural extract used in traditional medicine in Cuba. In clinically relevant experimental settings, scorpion venom does not induce general toxicity or an increase in the frequency of micronucleus formation in erythrocytes.
Díaz-García A, Ruiz-Fuentes JL, Mejias Medina S, Zapata Guajardo N, Ross Skarneo C.   +4 more
europepmc   +2 more sources

Formation of viable cell fragments by treatment with colchicine [PDF]

, 1976
Time-lapse cinematography of human fibroblasts revealed that mitotic cells separated into numerous cell fragments containing varying amounts of chromatin and cytoplasm when treated with colchicine.
Abercrombie, Becker, Borisy, C. Cremer, C. Zorn, Cremer, Ege, Ege, Ege, Goldman, Hayflick, J. Zimmer, Phillips, Phillips, Stubblefield, T. Cremer, Van den Brenk, Wessels, Zorn   +18 more
core   +1 more source

Enhancement of Micronuclei Frequency in the Tradescantia/Micronuclei Test Using a Long Recovery Time [PDF]

Hereditas, 2004
The Tradescantia/micronuclei test (TRAD/MCN) is a well-validated test for monitoring environmental genotoxicants. These pollutants induce at the early meiotic stage of pollen mother cells chromosome fragments which become micronuclei at the tetrad stage.
FALISTOCCO E, TORRICELLI R, FERETTI, Donatella, ZERBINI, Ilaria, ZANI, Claudia, MONARCA S.   +5 more
openaire   +5 more sources

Chronic ethanol consumption in mice does not induce DNA damage in somatic or germ cells, evaluated by the bone marrow micronucleous assay and the dominant lethal mutation assay [PDF]

, 2012
Indexación: Web of Science; ScieloAlthough alcohol is known to be a carcinogen for humans, ethanol-genotoxicity studies are incomplete. Ethanol seems not to be a bacterial mutagen, but the results are conflicting in rodent assays.
Ellahueñe, Manuel, Olmedo, María Isabel, Perez-Alzola, Patricia   +2 more
core   +1 more source

Identification of Micronuclei in the Lymphocytes of the Type 2 Diabetes Mellitus According to the Period of Diagnosis as a Biomarker

Polytechnic Journal, 2023
Micronuclei in lymphocytes can indicate DNA damage or chromosomal instability. This study aimed to compare the Micronuclei to the different period diagnoses of type 2 diabetes mellitus. Four groups were created out of 140 people: type 2 diabetes mellitus
Harem Othman Smail
doaj   +1 more source