Results 31 to 40 of about 32,768 (229)

cGAS surveillance of micronuclei links genome instability to innate immunity

Nature, 2017
DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP–AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA damage.
K. Mackenzie, P. Carroll, Carol-Anne Martin, O. Murina, Adeline Fluteau, Daniel P. Simpson, Nelly N Olova, H. Sutcliffe, J. Rainger, Andrea K Robertson, R. Osborn, Ann Wheeler, M. Nowotny, N. Gilbert, Tamir Chandra, Martin A. M. Reijns, A. Jackson   +16 more
semanticscholar   +1 more source

Paternal cyclophosphamide exposure induces the formation of functional micronuclei during the first zygotic division. [PDF]

PLoS ONE, 2011
Paternal exposures to cancer chemotherapeutics or environmental chemicals may have adverse effects on progeny outcome that are manifested in the preimplantation embryo.
Lisanne Grenier, Bernard Robaire, Barbara F Hales   +2 more
doaj   +1 more source

Mitotic progression following DNA damage enables pattern recognition within micronuclei

Nature, 2017
Inflammatory gene expression following genotoxic cancer therapy is well documented, yet the events underlying its induction remain poorly understood. Inflammatory cytokines modify the tumour microenvironment by recruiting immune cells and are critical ...
S. Harding, Joseph L. Benci, J. Irianto, D. Discher, A. Minn, R. Greenberg   +5 more
semanticscholar   +1 more source

Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures

Environmental Health, 2017
Background Ionizing radiation is a well-known carcinogen. Chromosome aberrations, and in particular micronuclei represent an early biological predictor of cancer risk.
D. Bazyka, S. C. Finch, I. M. Ilienko, O. Lyaskivska, I. Dyagil, N. Trotsiuk, N. Gudzenko, V. V. Chumak, K. M. Walsh, J. Wiemels, M. P. Little, L.B. Zablotska   +11 more
doaj   +1 more source

Enhancement of Micronuclei Frequency in the Tradescantia/Micronuclei Test Using a Long Recovery Time [PDF]

Hereditas, 2004
The Tradescantia/micronuclei test (TRAD/MCN) is a well-validated test for monitoring environmental genotoxicants. These pollutants induce at the early meiotic stage of pollen mother cells chromosome fragments which become micronuclei at the tetrad stage.
FALISTOCCO E, TORRICELLI R, FERETTI, Donatella, ZERBINI, Ilaria, ZANI, Claudia, MONARCA S.   +5 more
openaire   +5 more sources

Bacterial-induced cell fusion is a danger signal triggering cGAS–STING pathway via micronuclei formation

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Burkholderia pseudomallei is a bacterial pathogen that causes melioidosis, an infectious disease in the tropics with high morbidity and mortality. It has a unique property among bacteria: to fuse infected host cells. We found that our immune
J. W. K. Ku, Yahua Chen, B. Lim, S. Gasser, K. Crasta, Y. Gan   +5 more
semanticscholar   +1 more source

Properties of grape seed proanthocyanidins and quercetin in human lymphocytes [PDF]

Archives of Biological Sciences, 2008
This study addresses the in vitro protective effects of proanthocyanidins and quercetin on the frequency of micronuclei with reference to the antioxidant status of cultured human lymphocytes also subjected to 2 Gy of γ-radiation. Treatment of lymphocytes
Stanković Miroslava, Horvat Anica
doaj   +1 more source

Relationship between oxidative stress biomarkers and micronuclei scoring as a biomarker for DNA damage in Egyptian nicotine-dependent smokers: A cross-sectional study

Journal of the Arab Society for Medical Research, 2023
Background/aim About one-fifth of cancer deaths are caused by tobacco smoking. Nicotine-related DNA damage is thought to be the result of oxidative stress, whereas DNA damage can be represented in the form of binucleated micronuclei (BMNi).
Asmaa Mahmoud Mohammed, Dalia Farouk, Adel F. Hashish   +2 more
doaj   +1 more source

Effect of systemic treatment on the micronuclei frequency in the peripheral blood of patients with metastatic colorectal cancer

Oncology Letters, 2019
Colorectal cancer (CRC) is the third most diagnosed type of cancer affecting males, and the second most diagnosed type of cancer affecting females, and one of the leading causes of cancer-related mortality globally. The estimation of the micronuclei (MN)
T. Nikolouzakis, Polychronis D. Stivaktakis, P. Apalaki, Katerina Kalliantasi, T. M. Sapsakos, D. Spandidos, A. Tsatsakis, J. Souglakos, J. Tsiaoussis   +8 more
semanticscholar   +1 more source

Identification of Micronuclei in the Lymphocytes of the Type 2 Diabetes Mellitus According to the Period of Diagnosis as a Biomarker

Polytechnic Journal, 2023
Micronuclei in lymphocytes can indicate DNA damage or chromosomal instability. This study aimed to compare the Micronuclei to the different period diagnoses of type 2 diabetes mellitus. Four groups were created out of 140 people: type 2 diabetes mellitus
Harem Othman Smail
doaj   +1 more source