Results 41 to 50 of about 32,768 (229)

Comparative evaluation of genotoxicity in tobacco users versus nontobacco users

Journal of Pharmacy and Bioallied Sciences, 2021
Background: Many of the contents of cigarette smoke are genotoxic in nature, and consequently, cytogenetic injury seems to be a trustworthy biomarker for deciding the influence of exposure to chromosome damaging agents in smoke.
Arun Jacob Thomas, Bindu J Nair, Sajna Oommen, V Syamkumar, Resmi K Raman   +4 more
doaj   +1 more source

Active DNA end processing in micronuclei of ovarian cancer cells

BMC Cancer, 2018
Background Ovarian cancer is one of the most deadly gynecological malignancies and inclined to recurrence and drug resistance. Previous studies showed that the tumorigenesis of ovarian cancers and their major histotypes are associated with genomic ...
Zizhi Tang, Juan Yang, Xin Wang, Ming Zeng, Jing Wang, Ao Wang, Mingcai Zhao, Liandi Guo, Cong Liu, Dehua Li, Jie Chen   +10 more
doaj   +1 more source

Genotoxic effects of the diesel water-soluble fraction on the seahorse Hippocampus reidi (Teleostei: Syngnathidae) during acute exposure

Zoologia (Curitiba), 2010
The high toxicity of diesel components makes oil spills a threat to the biota in coastal marine environments. The genotoxic effect of the diesel water-soluble fraction (DWSF) on Hippocampus reidi (Ginsburg, 1933) was assessed.
Celina Alcoforado Santos, Larissa Simões Novaes, Levy Carvalho Gomes   +2 more
doaj   +1 more source

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements

Science
Chromosomal instability (CIN) generates micronuclei—aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer.
Sara Martin, Simone Scorzoni, Sara Cordone, Alice Mazzagatti, Galina V. Beznoussenko, Amanda L. Gunn, Melody Di Bona, Yonatan Eliezer, Gil Leor, Tal Ben-Yishay, A. Loffreda, Valeria Cancila, Maria Chiara Rainone, M. Ippolito, Valentino Martis, Fabio Bedin, M. Garrè, L. P. Vaites, Paolo Vasapolli, Simona Polo, D. Parazzoli, C. Tripodo, Alexander A. Mironov, A. Cuomo, U. Ben-David, S. Bakhoum, Emily M. Hatch, Peter Ly, S. Santaguida   +28 more
semanticscholar   +1 more source

An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability

Cells, 2020
Micronuclei are small, extranuclear bodies that are distinct from the primary cell nucleus. Micronucleus formation is an aberrant event that suggests a history of genotoxic stress or chromosome mis-segregation events.
Chloe C. Lepage, Laura L. Thompson, Bradley Larson, Kirk J. McManus   +3 more
doaj   +1 more source

ER Stress and Micronuclei Cluster: Stress Response Contributes to Genome Chaos in Cancer

Frontiers in Cell and Developmental Biology, 2021
Micronuclei is a cytogenetic term describing small nuclei composed of one to a few chromosomes or chromosomal fragments, which often result from abnormal cell divisions (Fenech et al., 2016).
Eric Heng, A. Moy, Guo Liu, H. Heng, Kezhong Zhang   +4 more
semanticscholar   +1 more source

The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology

Frontiers in Public Health, 2021
The effect of the reportedly low ionizing radiation doses, such as those very often delivered to patients in interventional cardiology, remains ambiguous.
Martha Habibi, Martha Habibi, Panagiotis K. Karyofyllis, Aggeliki Nikolakopoulou, Aggeliki Nikolakopoulou, Panagiotis Papagiannis, Pantelis Karaiskos, Alexandros G. Georgakilas, Vasiliki I. Hatzi, Ioannis Malakos, Nikolaos Kollaros, Irene Mastorakou, Vassilis Voudris, Georgia I. Terzoudi   +13 more
doaj   +1 more source

Micronuclei and Genome Chaos: Changing the System Inheritance

Genes, 2019
Micronuclei research has regained its popularity due to the realization that genome chaos, a rapid and massive genome re-organization under stress, represents a major common mechanism for punctuated cancer evolution.
C. Ye, Zachary Sharpe, Sarah Alemara, Stephanie Mackenzie, Guo Liu, Batoul Y. Abdallah, S. Horne, Sarah M. Regan, H. Heng   +8 more
semanticscholar   +1 more source

Micronuclei assay by laser scanning cytometry [PDF]

Cytometry, 2001
The micronuclei (MN) assay is used to assess the chromosomal/mitotic spindle damage induced by ionizing radiation or mutagenic agents in vivo or in vitro. Because visual scoring of MN is cumbersome semi-automatic procedures that relay either on flow cytometry or image analysis were developed: both offer some advantages but also have shortcomings.In the
P, Smolewski, Q, Ruan, L, Vellon, Z, Darzynkiewicz   +3 more
openaire   +2 more sources

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

Journal of Experimental Medicine, 2019
Cellular innate immune sensors of DNA are essential for host defense against invading pathogens. However, the presence of self-DNA inside cells poses a risk of triggering unchecked immune responses.
Matthieu Gratia, M. Rodero, Cécile Conrad, Elias Bou Samra, Mathieu Maurin, G. Rice, D. Duffy, P. Revy, F. Petit, R. Dale, Y. Crow, M. Amor-Guéret, N. Manel   +12 more
semanticscholar   +1 more source