Results 51 to 60 of about 32,768 (229)

Combination of CHEK1/2 Inhibition and Ionizing Radiation Results in Abscopal Tumor Response through Increased Micronuclei Formation

Oncogene, 2020
We explore a novel strategy of activating immune signaling through increased micronuclei formation utilizing a cell cycle checkpoint inhibitor to drive cell cycle progression following ionizing radiation.
H. Chao, Ilias V. Karagounis, Christoforos Thomas, Noelle B. Francois, A. Facciabene, C. Koumenis, A. Maity   +6 more
semanticscholar   +1 more source

Evaluation of genotoxic effect of amalgam restorations in oral cavity

Journal of Orofacial Sciences, 2015
Background: Mercury a popular heavy metal used in dentistry in the form of amalgam is a known clastogen. The assessment of micronuclei in cells is a promising tool for studying the genotoxic effect of mercury on them.
Chennoju Sai Kiran, Reddy Sudhakara Reddy, Rajesh Nallakunta   +2 more
doaj   +1 more source

Alerting the immune system to DNA damage: micronuclei as mediators

Essays in Biochemistry, 2020
Healthy cells experience thousands of DNA lesions per day during normal cellular metabolism, and ionizing radiation and chemotherapeutic drugs rely on DNA damage to kill cancer cells.
Kate M. MacDonald, Soraya Benguerfi, S. Harding   +2 more
semanticscholar   +1 more source

The effects of sex, age and cigarette smoking on micronucleus and degenerative nuclear alteration frequencies in human buccal cells of healthy Bosnian subjects

Journal of Health Sciences, 2013
Introduction: This study was performed to establish a baseline value of micronucleus frequency in buccal cells and to estimate the impact of the most common factors (sex and age, and smoking) on micronucleus and degenerative nuclear alteration ...
Hilada Nefić, Jasmin Mušanović, Kemajl Kurteshi, Enida Prutina, Elvira Turcalo   +4 more
doaj   +1 more source

Carassius auratus as a novel model for the hyperglycemia study [PDF]

The Ukrainian Biochemical Journal, 2019
The aim of the present study was to create a suitable model of the glucose toxicity and elucidate the ability of zinc-binding proteins metallothioneins in the crucian carp Carassius auratus to reflect it.
H. I. Falfushynska, O. I. Horyn, L. L. Gnatyshyna, B. B. Buyak, N. I. Rusnak, O. O. Fedoruk, O. B. Stoliar   +6 more
doaj   +1 more source

Cytogenetic effect of caffeine in the micronucleus test

RUDN Journal of Medicine, 2021
Relevance. The consumption of caffeine-containing food in the modern world must necessarily be safe for humans, including should not affect the hereditary material of the body.
N. A. Durnova, A. R. Klantsataya, M. N. Kurchatova, A. Yu. Karetnikova, A. S. Sheremetyeva   +4 more
doaj   +1 more source

Trimodal cytological integration of micronuclei assay, argyrophilic nucleolar organizer region staining, and cytomorphometry enhances diagnostic discrimination of canine gingival masses [PDF]

Veterinary World
Background and Aim: Canine gingival masses are common oral lesions with variable biological behavior, ranging from reactive hyperplasia to malignant neoplasia.
Poppapak Hoonpo, Tawewan Issarankura Na Ayudhaya, Kridsada Chaichoun, Panpanga Sangsuriya, Thanongsak Mamom, Parin Suwannaprapha   +5 more
doaj   +1 more source

Extracellular vesicles from genetically unstable, oncogene-driven cancer cells trigger micronuclei formation in endothelial cells

Scientific Reports, 2020
Oncogenic transformation impacts cancer cell interactions with their stroma, including through formation of abnormal blood vessels. This influence is often attributed to angiogenic growth factors, either soluble, or associated with tumor cell-derived ...
S. Chennakrishnaiah, Thupten Tsering, C. Gregory, Nadim Tawil, C. Spinelli, Laura Montermini, Nicolaos Karatzas, Saro Aprikian, Dongsic Choi, L. Klewes, S. Mai, J. Rak   +11 more
semanticscholar   +1 more source

Extracting and analyzing micronuclei from mouse two-cell embryos fertilized with freeze-dried spermatozoa

Communications Biology
Abnormal chromosome segregation (ACS) in preimplantation embryos causes miscarriages. For a normal pregnancy, it is necessary to reduce ACS occurrences in embryos.
Ikue Shibasaki, Hinata Sugiyama, Yuko Kamada, Hiroaki Nagatomo, Daiyu Ito, Sayaka Wakayama, Masatoshi Ooga, Tsuyoshi Kasai, Takashi Kohda, Teruhiko Wakayama   +9 more
doaj   +1 more source

Micronuclei Assay v1

, 2018

Jaroslav Pejchal, Ales Tichy
openaire   +1 more source