Results 61 to 70 of about 32,768 (229)
Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes
International Journal of Cancer, 2020 Micronuclei, small spatially‐separated, nucleus‐like structures, are a common feature of human cancer cells. There are considerable heterogeneities in the sources, structures and genetic activities of micronuclei.
Xihan Guo +4 more
semanticscholar +1 more source
Central Asian Journal of Global Health, 2019 Introduction: Occupational exposure to ionizing radiation can potentially lead to adverse health effects, including cancer and genetic defects. Genetic damage caused by radiation can be detected if micronuclei are observed.
Nicolas Padilla-Raygoza +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Some eukaryotes exhibit dramatic genome size differences between cells of different organs, resulting from the programmed elimination of chromosomes. Aegilops speltoides is an annual diploid species from the Poaceae family, with a maximum number of eight
Daiyan Li +8 more
doaj +1 more source
DNA replication occurs in all lamina positive micronuclei, but never in lamina negative micronuclei [PDF]
Mutagenesis, 2011 A micronucleus is a small nucleus-like structure found in the cytoplasm of dividing cells that suffered from genotoxic stress. It is generally hypothesised that micronuclei content is eventually lost from cells, though the mechanism of how this occurs is unknown.
Atsushi, Okamoto +2 more
openaire +2 more sources
Scientific Reports, 2020 In most organisms, cells typically maintain genome integrity, as radical genome reorganization leads to dramatic consequences. However, certain organisms, ranging from unicellular ciliates to vertebrates, are able to selectively eliminate specific parts ...
D. Dedukh +8 more
semanticscholar +1 more source
Genotoxicity in oral mucosal epithelial cells of petrol station attendants: A micronucleus study
Journal of Cytology, 2021 Introduction: Occupational exposure to petrol derivatives possesses an increased risk of various cancers including that of the oral mucosa. Scientific studies have shown the correlation of micronuclei assay (MN) with the cytogenotoxic changes in petrol ...
Shweta Rehani +5 more
doaj +1 more source
Micronuclei with multiple copies of the X chromosome: do chromosomes replicate in micronuclei? [PDF]
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004 The formation of a micronucleus due to chromosome lagging is a well known mechanism of chromosomal loss. However, the post-mitotic fate of the micronucleus and the chromosomal DNA within it is poorly understood. We observed micronuclei (MN) that had multiple copies of the X chromosome (ranging from 4 to 10) when analyzing cultured human lymphocytes ...
Natalia Tszine, Leach +1 more
openaire +2 more sources
Oncogenesis, 2019 Micronuclei represent the cellular attempt to compartmentalize DNA to maintain genomic integrity threatened by mitotic errors and genotoxic events. Some micronuclei show aberrant nuclear envelopes (NEs) that collapse, generating damaged DNA that can ...
Jessica Willan +9 more
semanticscholar +1 more source
Folia Oecologica, 2022 The cytogenetic analysis of the Pinus sylvestris L. seed progeny in the forests of the northern taiga in the Far North of Russia conditions was carried out.
Ignatenko Roman Viktorovich +2 more
doaj +1 more source
Mitotic clustering of pulverized chromosomes from micronuclei
Nature, 2023 Abstract Complex genome rearrangements can be generated by the catastrophic pulverization of missegregated chromosomes trapped within micronuclei through a process known as chromothripsis 1–5 .
Yu-Fen Lin +13 more
openaire +3 more sources